STRINGSTRING
ADAMTS12 ADAMTS12 BBS1 BBS1 PTH1R PTH1R TRIP11 TRIP11 EXT2 EXT2 MAPK14 MAPK14 BMP1 BMP1 RARG RARG OSR1 OSR1 FGF18 FGF18 OSR2 OSR2 BARX2 BARX2 ESRRA ESRRA TYMS TYMS ANXA6 ANXA6 LTBP3 LTBP3 PKD1 PKD1 ACAN ACAN EVC EVC SMPD3 SMPD3 SLC39A14 SLC39A14 DLX2 DLX2 PBXIP1 PBXIP1 IFT80 IFT80 SULF2 SULF2 CREB3L2 CREB3L2 BBS2 BBS2 SOX9 SOX9 ENSCANP00000033948 ENSCANP00000033948 COL11A1 COL11A1 FGFR3 FGFR3 WNT2B WNT2B MATN3 MATN3 NFIB NFIB NPPC NPPC SNX19 SNX19 WNT5A WNT5A MSX1 MSX1 TGFBI TGFBI BMPR2 BMPR2 LOC105506399 LOC105506399 ECM1 ECM1 SHOX2 SHOX2 BMP8B BMP8B COL27A1 COL27A1 CD44 CD44 RUNX3 RUNX3 CHST11 CHST11 OTOR OTOR CCN3 CCN3 HIF1A HIF1A COL2A1 COL2A1 RSPO2 RSPO2 RARB RARB ATP7A ATP7A MUSTN1 MUSTN1 HAND2 HAND2 SRF SRF HAND1 HAND1 CER1 CER1 SULF1 SULF1 SNAI1 SNAI1 CHRDL2 CHRDL2 GDF5 GDF5 MEF2D MEF2D EXT1 EXT1 BMP3 BMP3 EIF2AK3 EIF2AK3 ENSCANP00000023626 ENSCANP00000023626 BMP7 BMP7 CCN2 CCN2 HYAL2 HYAL2 COL1A1 COL1A1 RUNX2 RUNX2 HOXC4 HOXC4 MEX3C MEX3C COL3A1 COL3A1 IL17F IL17F TWSG1 TWSG1 SOX6 SOX6 ENSCANP00000019299 ENSCANP00000019299 WNT7A WNT7A FGF9 FGF9 THBS3 THBS3 EPYC EPYC SMAD1 SMAD1 MMP13 MMP13 SFRP2 SFRP2 HOXD3 HOXD3 CNMD CNMD RARA RARA RUNX1 RUNX1 SMAD5 SMAD5 GDF2 GDF2 HMGA2 HMGA2 ARID5A ARID5A MAPK3 MAPK3 GLI3 GLI3 GPLD1 GPLD1 WNT5B WNT5B MGP MGP CHSY1 CHSY1 PITX1 PITX1 CYTL1 CYTL1 ENSCANP00000013869 ENSCANP00000013869 WNT10B WNT10B BMP4 BMP4 SIX2 SIX2 BMPR1A BMPR1A PRRX1 PRRX1 SOX5 SOX5 SERPINH1 SERPINH1 BMP2 BMP2 HOXB3 HOXB3 SCUBE2 SCUBE2 STC1 STC1 SNAI2 SNAI2 ZEB1 ZEB1 GHRL GHRL FGF6 FGF6 CTNNB1 CTNNB1 COL11A2 COL11A2 TAPT1 TAPT1 DDRGK1 DDRGK1 SATB2 SATB2 HOXA5 HOXA5 DSPP DSPP BMP6 BMP6 THRA THRA TGFB1 TGFB1 BMPR1B BMPR1B BMP5 BMP5 IMPAD1 IMPAD1 ZBTB16 ZBTB16 MEF2C MEF2C BGN BGN HOXA11 HOXA11 MKKS MKKS ZMPSTE24 ZMPSTE24 HOXA3 HOXA3 COMP COMP LOC105521177 LOC105521177 ATF2 ATF2 WNT7B WNT7B TRPV4 TRPV4 TSKU TSKU CCN1 CCN1 TGFBR2 TGFBR2 NOG NOG LOC105517826 LOC105517826 MYF5 MYF5 IHH IHH HYAL3 HYAL3 AXIN2 AXIN2 HYAL1 HYAL1 MATN1 MATN1 EDN1 EDN1 ADAMTS7 ADAMTS7 ITGB8 ITGB8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
BBS1BBS1 domain-containing protein. (593 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (592 aa)
TRIP11Thyroid hormone receptor interactor 11. (1938 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BMP1Metalloendopeptidase. (980 aa)
RARGRetinoic acid receptor gamma. (461 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
OSR2Odd-skipped related transciption factor 2. (418 aa)
BARX2BARX homeobox 2. (279 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
TYMSThymidylate synthetase. (313 aa)
ANXA6Annexin. (683 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1127 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4053 aa)
ACANAggrecan. (2167 aa)
EVCEvC ciliary complex subunit 1. (863 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
DLX2Distal-less homeobox 2. (328 aa)
PBXIP1PBX homeobox interacting protein 1. (736 aa)
IFT80Intraflagellar transport 80. (777 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (461 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ENSCANP00000033948Homeobox domain-containing protein. (141 aa)
COL11A1Collagen type XI alpha 1 chain. (1764 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
MATN3Matrilin 3. (427 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
NPPCNatriuretic peptide C. (126 aa)
SNX19Sorting nexin 19. (992 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MSX1Msh homeobox 1. (199 aa)
TGFBITransforming growth factor beta induced. (690 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
LOC105506399Uncharacterized protein. (246 aa)
ECM1Extracellular matrix protein 1. (567 aa)
SHOX2Short stature homeobox 2. (221 aa)
BMP8BTGF_BETA_2 domain-containing protein. (336 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1839 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (366 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
OTOROtoraplin. (128 aa)
CCN3Cellular communication network factor 3. (357 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
RSPO2R-spondin 2. (243 aa)
RARBRetinoic acid receptor beta. (448 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
MUSTN1Uncharacterized protein. (87 aa)
HAND2Uncharacterized protein. (66 aa)
SRFSerum response factor. (406 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (873 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
CHRDL2Chordin like 2. (452 aa)
GDF5Growth differentiation factor 5. (499 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
ENSCANP00000023626Uncharacterized protein. (84 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CCN2Cellular communication network factor 2. (301 aa)
HYAL2Hyaluronidase. (473 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
HOXC4Homeobox C4. (264 aa)
MEX3CMex-3 RNA binding family member C. (570 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
IL17FInterleukin 17F. (163 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SOX6SRY-box transcription factor 6. (828 aa)
ENSCANP00000019299Uncharacterized protein. (366 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
THBS3Thrombospondin 3. (961 aa)
EPYCEpiphycan. (322 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MMP13Matrix metallopeptidase 13. (503 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
HOXD3Homeobox D3. (432 aa)
CNMDChondromodulin. (334 aa)
RARARetinoic acid receptor alpha. (478 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (455 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
GDF2Growth differentiation factor 2. (429 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
ARID5AAT-rich interaction domain 5A. (592 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
GLI3GLI family zinc finger 3. (1580 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
CHSY1Hexosyltransferase. (716 aa)
PITX1Homeobox protein. (298 aa)
CYTL1Cytokine like 1. (136 aa)
ENSCANP00000013869Thymidylat_synt domain-containing protein. (134 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SIX2SIX homeobox 2. (292 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PRRX1Paired related homeobox 1. (245 aa)
SOX5SRY-box transcription factor 5. (763 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HOXB3Homeobox B3. (430 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (954 aa)
STC1Stanniocalcin 1. (247 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CTNNB1Catenin beta 1. (781 aa)
COL11A2Collagen type XI alpha 2 chain. (1613 aa)
TAPT1Transmembrane anterior posterior transformation 1. (500 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
SATB2DNA-binding protein SATB. (733 aa)
HOXA5Homeobox A5. (270 aa)
DSPPDentin sialophosphoprotein. (1113 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
THRAThyroid hormone receptor alpha. (593 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (368 aa)
HOXA11Homeobox A11. (312 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (489 aa)
HOXA3Homeobox A3. (443 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
LOC105521177TGF_BETA_2 domain-containing protein. (238 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
CCN1Cellular communication network factor 1. (381 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC105517826SERPIN domain-containing protein; Belongs to the serpin family. (382 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
IHHIndian hedgehog signaling molecule. (373 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
AXIN2Axin 2. (843 aa)
HYAL1Hyaluronidase. (450 aa)
MATN1Matrilin 1. (496 aa)
EDN1Endothelin 1. (211 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1676 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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