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MYBPC3 MYBPC3 MYLK2 MYLK2 TNNC1 TNNC1 MED1 MED1 PKP2 PKP2 MYL2 MYL2 S1PR1 S1PR1 MYL10 MYL10 ENG ENG NOG NOG RYR2 RYR2 TCAP TCAP SMAD7 SMAD7 MYH7 MYH7 NKX2-5 NKX2-5 TGFB1 TGFB1 DSP DSP TNNI3 TNNI3 BMP10 BMP10 SMAD4 SMAD4 TGFBR1 TGFBR1 PROX1 PROX1 ENSCANP00000030255 ENSCANP00000030255 TTN TTN WNT5A WNT5A EGLN1 EGLN1 TNNI1 TNNI1 LRP2 LRP2 COL11A1 COL11A1 TBX20 TBX20 XIRP2 XIRP2 CHD7 CHD7 ENSCANP00000036326 ENSCANP00000036326 POU4F1 POU4F1 ISL1 ISL1 ANKRD1 ANKRD1 ENSCANP00000038657 ENSCANP00000038657 MYH6 MYH6 MYL3 MYL3 FOXH1 FOXH1 BMP2 BMP2 HEG1 HEG1 BMPR1A BMPR1A DLL4 DLL4 TGFBR3 TGFBR3 WNT2 WNT2 FGFR2 FGFR2 ZFPM2 ZFPM2 TGFB2 TGFB2 HEY2 HEY2 EDNRA EDNRA TNNT2 TNNT2 PTCD2 PTCD2 HAND1 HAND1 NOTCH1 NOTCH1 NRG1 NRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYBPC3Myosin binding protein C, cardiac. (1306 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa)
PKP2Plakophilin 2. (882 aa)
MYL2Myosin light chain 2. (166 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
MYL10Myosin light chain 10. (225 aa)
ENGEndoglin. (658 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RYR2Ryanodine receptor 2. (4920 aa)
TCAPTitin-cap. (167 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
NKX2-5NK2 homeobox 5. (324 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
DSPDesmoplakin. (2510 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSCANP00000030255Fork-head domain-containing protein. (189 aa)
TTNTitin. (32000 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
TNNI1Troponin I1, slow skeletal type. (187 aa)
LRP2LDL receptor related protein 2. (4655 aa)
COL11A1Collagen type XI alpha 1 chain. (1764 aa)
TBX20T-box transcription factor 20. (447 aa)
XIRP2Xin actin binding repeat containing 2. (3549 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
ENSCANP00000036326Uncharacterized protein. (144 aa)
POU4F1POU domain protein. (288 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
MYL3Myosin light chain 3. (201 aa)
FOXH1Forkhead box H1. (366 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HEG1Heart development protein with EGF like domains 1. (1274 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1137 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
NOTCH1Notch receptor 1. (2559 aa)
NRG1Neuregulin 1. (645 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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