STRINGSTRING
INSIG1 INSIG1 ABCA1 ABCA1 LPL LPL LOC105504501 LOC105504501 MTTP MTTP LCAT LCAT TLCD2 TLCD2 DDX3X DDX3X CETP CETP EPHX2 EPHX2 DGAT2 DGAT2 RTN4 RTN4 G6PC G6PC USF1 USF1 NR1D2 NR1D2 TLCD4 TLCD4 ABCA5 ABCA5 POLD1 POLD1 APOE APOE COMMD9 COMMD9 NR5A2 NR5A2 MYLIP MYLIP GCKR GCKR ADCK1 ADCK1 GIP GIP LAMTOR1 LAMTOR1 CLN8 CLN8 DISP3 DISP3 CD24 CD24 NFE2L1 NFE2L1 FABP3 FABP3 SURF4 SURF4 HDAC9 HDAC9 GRAMD1B GRAMD1B SESN2 SESN2 CYP39A1 CYP39A1 ENSCANP00000028764 ENSCANP00000028764 RALY RALY FUNDC2 FUNDC2 SOAT1 SOAT1 NPC1L1 NPC1L1 TLCD1 TLCD1 PNPLA1 PNPLA1 RALYL RALYL FITM2 FITM2 ACOX2 ACOX2 FBXW7 FBXW7 SCARB1 SCARB1 ENPP7 ENPP7 ABCG4 ABCG4 PNPLA2 PNPLA2 LRP5 LRP5 PLA2G12B PLA2G12B MTCH2 MTCH2 TTC39A TTC39A RORA RORA DGAT1 DGAT1 APOC4 APOC4 HNF4A HNF4A MED13 MED13 NPC1 NPC1 RCN3 RCN3 TLCD3A TLCD3A LDLRAP1 LDLRAP1 PCSK9 PCSK9 ZBTB20 ZBTB20 SREBF2 SREBF2 CYP7B1 CYP7B1 ABCD1 ABCD1 PRKAA2 PRKAA2 PLSCR3 PLSCR3 PNPLA3 PNPLA3 TLCD3B TLCD3B ABCA12 ABCA12 ENSCANP00000025349 ENSCANP00000025349 OR10J5 OR10J5 ABCG1 ABCG1 ABCG5 ABCG5 ORMDL2 ORMDL2 ACSM1 ACSM1 ENSCANP00000024205 ENSCANP00000024205 LIMA1 LIMA1 XBP1 XBP1 SLC25A46 SLC25A46 APOA2 APOA2 TTC39B TTC39B ITGB6 ITGB6 LIPC LIPC GPIHBP1 GPIHBP1 MLXIPL MLXIPL CAV1 CAV1 TGFB1 TGFB1 LDLR LDLR ABCG8 ABCG8 NR1D1 NR1D1 NR1H2 NR1H2 LOC105502173 LOC105502173 PNPLA8 PNPLA8 LIPG LIPG ACACA ACACA ORMDL3 ORMDL3 SIRT1 SIRT1 GPAM GPAM THADA THADA ATP13A2 ATP13A2 APOA5 APOA5 NPC2 NPC2 FGFR4 FGFR4 SEC24A SEC24A CYP7A1 CYP7A1 NUS1 NUS1 MALRD1 MALRD1 TSKU TSKU ENSCANP00000004126 ENSCANP00000004126 ABCA2 ABCA2 RBP1 RBP1 NR1H3 NR1H3 ABHD4 ABHD4 USF2 USF2 TREM2 TREM2 ABCB11 ABCB11 PNPLA5 PNPLA5 C1QTNF3 C1QTNF3 ANGPTL3 ANGPTL3 ABCA3 ABCA3 NR1H4 NR1H4 TLCD5 TLCD5 SLC37A4 SLC37A4 TMEM97 TMEM97 FABP4 FABP4 PRKAA1 PRKAA1 PNPLA4 PNPLA4 ABHD8 ABHD8 SOAT2 SOAT2 MTLN MTLN TM6SF2 TM6SF2 TSPO TSPO CAV3 CAV3 ANGPTL8 ANGPTL8 LOC105507530 LOC105507530 APOB APOB IL18 IL18 APOC2 APOC2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
LOC105504501Uncharacterized protein. (210 aa)
MTTPMicrosomal triglyceride transfer protein. (909 aa)
LCATLecithin-cholesterol acyltransferase. (440 aa)
TLCD2TLC domain containing 2. (264 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (721 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
EPHX2Epoxide hydrolase 2. (547 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
RTN4Reticulon. (986 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
USF1Upstream transcription factor 1. (310 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (580 aa)
TLCD4TLC domain containing 4. (242 aa)
ABCA5ATP binding cassette subfamily A member 5. (1642 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1012 aa)
APOEApolipoprotein E. (189 aa)
COMMD9COMM domain containing 9. (198 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
GCKRGlucokinase regulator. (437 aa)
ADCK1AarF domain containing kinase 1. (523 aa)
GIPGLUCAGON domain-containing protein. (79 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
DISP3Dispatched RND transporter family member 3. (1390 aa)
CD24Uncharacterized protein. (127 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (772 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
SURF4Surfeit 4. (269 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
GRAMD1BGRAM domain containing 1B. (877 aa)
SESN2Sestrin 2. (479 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa)
ENSCANP00000028764Uncharacterized protein. (183 aa)
RALYRALY heterogeneous nuclear ribonucleoprotein. (309 aa)
FUNDC2FUN14 domain containing 2. (189 aa)
SOAT1O-acyltransferase. (525 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1326 aa)
TLCD1TLC domain containing 1. (247 aa)
PNPLA1Patatin like phospholipase domain containing 1. (532 aa)
RALYLRALY RNA binding protein like. (304 aa)
FITM2Fat storage inducing transmembrane protein 2. (262 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (450 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
PNPLA2Patatin like phospholipase domain containing 2. (428 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
MTCH2Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (294 aa)
TTC39ATetratricopeptide repeat domain 39A. (612 aa)
RORARAR related orphan receptor A. (555 aa)
DGAT1O-acyltransferase. (470 aa)
APOC4Uncharacterized protein. (127 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2173 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
RCN3Reticulocalbin 3. (328 aa)
TLCD3ATLC domain containing 3A. (216 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1123 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
ABCD1ATP binding cassette subfamily D member 1. (745 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (312 aa)
PNPLA3Patatin like phospholipase domain containing 3. (418 aa)
TLCD3BTLC domain containing 3B. (274 aa)
ABCA12ATP binding cassette subfamily A member 12. (2556 aa)
ENSCANP00000025349Uncharacterized protein. (100 aa)
OR10J5Olfactory receptor family 10 subfamily J member 5. (289 aa)
ABCG1ATP binding cassette subfamily G member 1. (684 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ACSM1Acyl-CoA synthetase medium chain family member 1. (462 aa)
ENSCANP00000024205Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
LIMA1LIM domain and actin binding 1. (753 aa)
XBP1X-box binding protein 1. (204 aa)
SLC25A46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
APOA2Apolipoprotein A2. (100 aa)
TTC39BTetratricopeptide repeat domain 39B. (682 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (746 aa)
LIPCLipase C, hepatic type. (499 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (141 aa)
MLXIPLMLX interacting protein like. (852 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
LDLRLow density lipoprotein receptor. (777 aa)
ABCG8ATP binding cassette subfamily G member 8. (620 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
LOC105502173RRM domain-containing protein. (250 aa)
PNPLA8Patatin like phospholipase domain containing 8. (782 aa)
LIPGLipase G, endothelial type. (500 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
SIRT1Sirtuin 1. (600 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
THADATHADA armadillo repeat containing. (1953 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1106 aa)
APOA5Apolipoprotein A5. (366 aa)
NPC2NPC intracellular cholesterol transporter 2. (229 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1078 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
MALRD1MAM and LDL receptor class A domain containing 1. (2080 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
ENSCANP00000004126Uncharacterized protein. (79 aa)
ABCA2ATP binding cassette subfamily A member 2. (2425 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (197 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
ABHD4Abhydrolase domain containing 4. (352 aa)
USF2Upstream transcription factor 2, c-fos interacting. (218 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
PNPLA5Patatin like phospholipase domain containing 5. (429 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
TLCD5TLC domain containing 5. (267 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
TMEM97Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (176 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PNPLA4Patatin like phospholipase domain containing 4. (253 aa)
ABHD8Abhydrolase domain containing 8. (438 aa)
SOAT2O-acyltransferase. (460 aa)
MTLNMitoregulin. (118 aa)
TM6SF2Transmembrane 6 superfamily member 2. (345 aa)
TSPOUncharacterized protein. (65 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
LOC105507530Uncharacterized protein. (462 aa)
APOBApolipoprotein B. (4555 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
APOC2Apolipoprotein C2. (101 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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