35 items (Colobus angolensis) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1137 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	FGFR2	Fibroblast growth factor receptor. (838 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (455 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (860 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	TBX2	T-box transcription factor 2. (590 aa)
	GATA6	GATA binding protein 6. (462 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	ENSCANP00000010884	Uncharacterized protein. (338 aa)
	YAP1	Yes associated protein 1. (479 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1283 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	VGLL4	Vestigial like family member 4. (296 aa)
	MAPK11	Mitogen-activated protein kinase. (306 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	GLI1	GLI family zinc finger 1. (1065 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (306 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1246 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	NRG1	Neuregulin 1. (645 aa)
	NOTCH1	Notch receptor 1. (2559 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (428 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	BMPR1A	ENSCANP00000029284	ENSCANP00000013474	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.602
BMP10	TGFBR1	ENSCANP00000029284	ENSCANP00000029823	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.602
BMP10	TGFBR2	ENSCANP00000029284	ENSCANP00000004177	Bone morphogenetic protein 10.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.411
BMPR1A	BMP10	ENSCANP00000013474	ENSCANP00000029284	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.602
BMPR1A	NOG	ENSCANP00000013474	ENSCANP00000003971	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.516
BMPR1A	PTEN	ENSCANP00000013474	ENSCANP00000010167	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.423
BMPR1A	TGFBR2	ENSCANP00000013474	ENSCANP00000004177	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.725
ENSCANP00000010884	ERBB4	ENSCANP00000010884	ENSCANP00000014043	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.829
ENSCANP00000010884	RUNX1	ENSCANP00000010884	ENSCANP00000016176	Uncharacterized protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.739
ENSCANP00000010884	SAV1	ENSCANP00000010884	ENSCANP00000007231	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.744
ENSCANP00000010884	TBX5	ENSCANP00000010884	ENSCANP00000019143	Uncharacterized protein.	T-box transcription factor 5.	0.771
ENSCANP00000010884	TGFBR1	ENSCANP00000010884	ENSCANP00000029823	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.673
ENSCANP00000010884	TGFBR2	ENSCANP00000010884	ENSCANP00000004177	Uncharacterized protein.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.661
ENSCANP00000010884	TP73	ENSCANP00000010884	ENSCANP00000013734	Uncharacterized protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.915
ENSCANP00000010884	VGLL4	ENSCANP00000010884	ENSCANP00000012588	Uncharacterized protein.	Vestigial like family member 4.	0.706
ERBB4	ENSCANP00000010884	ENSCANP00000014043	ENSCANP00000010884	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.829
ERBB4	FGF20	ENSCANP00000014043	ENSCANP00000010458	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.843
ERBB4	FGF9	ENSCANP00000014043	ENSCANP00000018634	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.843
ERBB4	NRG1	ENSCANP00000014043	ENSCANP00000027765	Receptor protein-tyrosine kinase.	Neuregulin 1.	0.992
ERBB4	PTEN	ENSCANP00000014043	ENSCANP00000010167	Receptor protein-tyrosine kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.440