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BMP4 BMP4 BMPR1A BMPR1A ACVR1 ACVR1 WNT11 WNT11 BMPR2 BMPR2 RBM15 RBM15 PROX1 PROX1 TGFBR1 TGFBR1 SMAD4 SMAD4 TP53 TP53 NOTCH1 NOTCH1 FZD2 FZD2 JAG1 JAG1 SLIT3 SLIT3 HAND1 HAND1 NSD2 NSD2 ROBO2 ROBO2 BMP7 BMP7 MKS1 MKS1 HEY2 HEY2 TGFB2 TGFB2 SEMA3C SEMA3C SLIT2 SLIT2 CITED2 CITED2 ZFPM2 ZFPM2 TBX5 TBX5 FGFR2 FGFR2 SOX11 SOX11 ISL1 ISL1 GATA4 GATA4 ENSCANP00000036326 ENSCANP00000036326 CHD7 CHD7 NRP1 NRP1 DHRS3 DHRS3 TBX20 TBX20 LRP2 LRP2 NRP2 NRP2 EGLN1 EGLN1 WNT5A WNT5A HEYL HEYL DNAH11 DNAH11 SAV1 SAV1 SMAD7 SMAD7 SMO SMO GATA6 GATA6 TBX2 TBX2 CCN1 CCN1 TGFBR2 TGFBR2 NOG NOG ENSCANP00000003738 ENSCANP00000003738 PARVA PARVA ENG ENG HEY1 HEY1 ROBO1 ROBO1 TGFBR3 TGFBR3 FGF8 FGF8 NOTCH2 NOTCH2 NKX2-5 NKX2-5 NOS3 NOS3 TBX3 TBX3 FGFRL1 FGFRL1 BMP5 BMP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4. (408 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
RBM15RNA binding motif protein 15. (980 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
NOTCH1Notch receptor 1. (2559 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
SLIT3Slit guidance ligand 3. (1500 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1137 aa)
TBX5T-box transcription factor 5. (518 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
SOX11Transcription factor SOX. (372 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GATA4GATA binding protein 4. (236 aa)
ENSCANP00000036326Uncharacterized protein. (144 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
TBX20T-box transcription factor 20. (447 aa)
LRP2LDL receptor related protein 2. (4655 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
DNAH11Dynein axonemal heavy chain 11. (4505 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
GATA6GATA binding protein 6. (462 aa)
TBX2T-box transcription factor 2. (590 aa)
CCN1Cellular communication network factor 1. (381 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSCANP00000003738Uncharacterized protein. (247 aa)
PARVAParvin alpha. (411 aa)
ENGEndoglin. (658 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
ROBO1Roundabout guidance receptor 1. (1598 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
NOTCH2Notch receptor 2. (2471 aa)
NKX2-5NK2 homeobox 5. (324 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
TBX3T-box transcription factor 3. (743 aa)
FGFRL1Fibroblast growth factor receptor like 1. (467 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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