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JAK2 JAK2 HSP90AB1 HSP90AB1 LOC105516700 LOC105516700 KDR KDR MSX1 MSX1 BMPR2 BMPR2 TGFB3 TGFB3 GDF3 GDF3 CDH5 CDH5 TGFB2 TGFB2 LOC105515531 LOC105515531 SLC2A10 SLC2A10 NUMA1 NUMA1 TWSG1 TWSG1 CITED2 CITED2 FGF9 FGF9 LRG1 LRG1 ZC3H3 ZC3H3 BMP15 BMP15 GDF2 GDF2 TGFBR3 TGFBR3 SNW1 SNW1 CDKN1C CDKN1C EP300 EP300 CCN1 CCN1 LOC105521177 LOC105521177 INHBA INHBA GATA6 GATA6 ACVR2A ACVR2A CDKN2A CDKN2A GDF10 GDF10 ENSCANP00000006130 ENSCANP00000006130 KCP KCP ENSCANP00000006850 ENSCANP00000006850 PELO PELO RNF165 RNF165 BMP5 BMP5 NOTCH2 NOTCH2 TGFB1 TGFB1 BMP6 BMP6 ADAM17 ADAM17 FBXL15 FBXL15 HIPK2 HIPK2 ACVRL1 ACVRL1 KIAA1324L KIAA1324L FERMT1 FERMT1 ING2 ING2 GIPC2 GIPC2 FLCN FLCN ZEB2 ZEB2 ACVR1 ACVR1 BMP2 BMP2 DAB2 DAB2 BMPR1A BMPR1A GDF7 GDF7 BMP4 BMP4 GDF6 GDF6 ZNF423 ZNF423 GIPC1 GIPC1 HFE HFE TGFBR2 TGFBR2 ENSCANP00000004166 ENSCANP00000004166 GDF11 GDF11 ENG ENG MEN1 MEN1 SDCBP SDCBP CITED1 CITED1 UBE2O UBE2O BMP8B BMP8B SCUBE3 SCUBE3 CREBBP CREBBP INHA INHA INHBE INHBE TGFBR1 TGFBR1 SMAD4 SMAD4 BMP10 BMP10 LOC105516701 LOC105516701 NOTCH1 NOTCH1 MYOCD MYOCD ACVR2B ACVR2B STK11 STK11 TGFB1I1 TGFB1I1 SULF1 SULF1 GDF5 GDF5 BMP3 BMP3 C20orf27 C20orf27 BMP7 BMP7 ACVR1B ACVR1B RBPMS RBPMS AXIN1 AXIN1 FKBP8 FKBP8 THBS1 THBS1 NUP93 NUP93 RNF111 RNF111 SOX11 SOX11 INHBC INHBC ITGA8 ITGA8 GIPC3 GIPC3 CRB2 CRB2 KIAA0319 KIAA0319 CDKN2B CDKN2B GATA4 GATA4 SMAD2 SMAD2 ENSCANP00000036443 ENSCANP00000036443 PARP1 PARP1 NEO1 NEO1 NODAL NODAL TBX20 TBX20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK2Tyrosine-protein kinase. (1139 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
LOC105516700TGF_BETA_2 domain-containing protein. (311 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MSX1Msh homeobox 1. (199 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF3Growth differentiation factor 3. (364 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (717 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC105515531HATPase_c domain-containing protein. (644 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (544 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2118 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
ZC3H3Zinc finger CCCH-type containing 3. (948 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
GDF2Growth differentiation factor 2. (429 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
SNW1SNW domain containing 1. (571 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (288 aa)
EP300E1A binding protein p300. (2409 aa)
CCN1Cellular communication network factor 1. (381 aa)
LOC105521177TGF_BETA_2 domain-containing protein. (238 aa)
INHBAInhibin subunit beta A. (426 aa)
GATA6GATA binding protein 6. (462 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
ENSCANP00000006130C2H2-type domain-containing protein. (254 aa)
KCPKielin cysteine rich BMP regulator. (1575 aa)
ENSCANP00000006850PDZ domain-containing protein. (282 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
RNF165Ring finger protein 165. (346 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
HIPK2Homeodomain interacting protein kinase 2. (1197 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
KIAA1324LKIAA1324 like. (1019 aa)
FERMT1Fermitin family member 1. (677 aa)
ING2Inhibitor of growth protein. (280 aa)
GIPC2GIPC PDZ domain containing family member 2. (282 aa)
FLCNFolliculin. (579 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
DAB2DAB adaptor protein 2. (770 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF7Growth differentiation factor 7. (366 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF6Growth differentiation factor 6. (455 aa)
ZNF423Zinc finger protein 423. (1191 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSCANP00000004166PDZ domain-containing protein. (294 aa)
GDF11Growth differentiation factor 11. (345 aa)
ENGEndoglin. (658 aa)
MEN1Menin 1. (610 aa)
SDCBPSyndecan binding protein. (318 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1154 aa)
BMP8BTGF_BETA_2 domain-containing protein. (336 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
CREBBPCREB binding protein. (2117 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
INHBEInhibin subunit beta E. (351 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
LOC105516701TGF_BETA_2 domain-containing protein. (283 aa)
NOTCH1Notch receptor 1. (2559 aa)
MYOCDMyocardin. (923 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (873 aa)
GDF5Growth differentiation factor 5. (499 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
C20orf27Chromosome 20 open reading frame 27. (174 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
RBPMSRNA binding protein, mRNA processing factor. (202 aa)
AXIN1Axin 1. (859 aa)
FKBP8Peptidylprolyl isomerase. (421 aa)
THBS1Thrombospondin 1. (1173 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (880 aa)
RNF111Ring finger protein 111. (994 aa)
SOX11Transcription factor SOX. (372 aa)
INHBCInhibin subunit beta C. (352 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1052 aa)
GIPC3GIPC PDZ domain containing family member 3. (281 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
KIAA0319KIAA0319. (1072 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
GATA4GATA binding protein 4. (236 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSCANP00000036443TPR_REGION domain-containing protein. (356 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
NEO1Neogenin 1. (1451 aa)
NODALNodal growth differentiation factor. (347 aa)
TBX20T-box transcription factor 20. (447 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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