STRINGSTRING
PCSK9 PCSK9 APOC2 APOC2 ABHD5 ABHD5 APOB APOB VSTM2B VSTM2B C1QTNF6 C1QTNF6 NMB NMB FIS1 FIS1 LEP LEP LOC105507530 LOC105507530 ENSCANP00000001668 ENSCANP00000001668 ITGAV ITGAV PPARG PPARG POMC POMC ENSCANP00000002034 ENSCANP00000002034 CRY1 CRY1 ACSL5 ACSL5 LRAT LRAT ENSCANP00000002557 ENSCANP00000002557 ABCA3 ABCA3 CRH CRH TREM2 TREM2 MIF MIF NR1H3 NR1H3 LPCAT3 LPCAT3 ABCA2 ABCA2 PRKCD PRKCD PRKN PRKN PRAP1 PRAP1 OSBPL11 OSBPL11 EEPD1 EEPD1 SCP2 SCP2 OSBPL6 OSBPL6 NUS1 NUS1 PLIN2 PLIN2 FURIN FURIN SEC24A SEC24A MAP2K6 MAP2K6 RXRA RXRA EPRS1 EPRS1 APOA5 APOA5 NFKBIA NFKBIA ACACB ACACB SIRT1 SIRT1 MSR1 MSR1 FASLG FASLG CRP CRP CAV1 CAV1 BMP6 BMP6 ENSCANP00000009431 ENSCANP00000009431 NKX3-1 NKX3-1 TTC39B TTC39B APOA2 APOA2 APOC4 APOC4 KDM5B KDM5B ENSCANP00000011220 ENSCANP00000011220 PTPN2 PTPN2 PTCH1 PTCH1 C3 C3 GHRL GHRL TSPO TSPO ABCA1 ABCA1 ENSCANP00000013104 ENSCANP00000013104 DAB2 DAB2 PON1 PON1 FITM1 FITM1 LPL LPL P2RX4 P2RX4 ENSCANP00000013829 ENSCANP00000013829 GAL GAL TNFSF11 TNFSF11 LOC105504501 LOC105504501 PLA2G3 PLA2G3 AKT1 AKT1 SPP1 SPP1 TNFRSF11A TNFRSF11A CETP CETP NAXE NAXE SYK SYK CRHR1 CRHR1 PPARD PPARD ECRG4 ECRG4 ENSCANP00000018729 ENSCANP00000018729 ABCA5 ABCA5 EGF EGF PLA2G4A PLA2G4A ABCA7 ABCA7 APOE APOE VSTM2A VSTM2A RETN RETN ANXA2 ANXA2 ZDHHC8 ZDHHC8 LAMTOR1 LAMTOR1 THBS1 THBS1 CYP8B1 CYP8B1 DISP3 DISP3 AKT2 AKT2 NTSR1 NTSR1 LIPG LIPG DBI DBI NR1H2 NR1H2 OSBPL8 OSBPL8 ABCG8 ABCG8 ENSCANP00000023654 ENSCANP00000023654 DENND5B DENND5B ITGB3 ITGB3 ENSCANP00000024205 ENSCANP00000024205 NFKB1 NFKB1 ABCG5 ABCG5 ABCG1 ABCG1 ABCA12 ABCA12 PPARA PPARA ENSCANP00000025796 ENSCANP00000025796 ATP8A1 ATP8A1 ADIPOQ ADIPOQ ATP8A2 ATP8A2 SREBF2 SREBF2 SURF4 SURF4 REN REN CRY2 CRY2 ERFE ERFE IKBKE IKBKE PRELID1 PRELID1 SHH SHH GPS2 GPS2 FITM2 FITM2 ABCA8 ABCA8 ARV1 ARV1 ABCA13 ABCA13 YJEFN3 YJEFN3 AVPR1B AVPR1B PTPN11 PTPN11 ACSL1 ACSL1 SCARB1 SCARB1 CD36 CD36 PLA2G6 PLA2G6 TMF1 TMF1 ENSCANP00000034934 ENSCANP00000034934 CIDEA CIDEA ACSL4 ACSL4 ENSCANP00000036145 ENSCANP00000036145 LDLRAP1 LDLRAP1 PLIN5 PLIN5 ZC3H12A ZC3H12A ENSCANP00000038043 ENSCANP00000038043 FABP3 FABP3 ENPP7 ENPP7 PLA2R1 PLA2R1 ABCG4 ABCG4 PNPLA2 PNPLA2 CYP19A1 CYP19A1 P2RX7 P2RX7 TTC39A TTC39A C1QTNF1 C1QTNF1 LRP1 LRP1 APOA1 APOA1 PLTP PLTP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
APOC2Apolipoprotein C2. (101 aa)
ABHD5Abhydrolase domain containing 5. (349 aa)
APOBApolipoprotein B. (4555 aa)
VSTM2BV-set and transmembrane domain containing 2B. (199 aa)
C1QTNF6C1q and TNF related 6. (278 aa)
NMBNeuromedin B. (121 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LOC105507530Uncharacterized protein. (462 aa)
ENSCANP00000001668Uncharacterized protein. (329 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
POMCProopiomelanocortin. (251 aa)
ENSCANP00000002034Uncharacterized protein. (114 aa)
CRY1Cryptochrome circadian regulator 1. (599 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (723 aa)
LRATLecithin retinol acyltransferase. (230 aa)
ENSCANP00000002557Uncharacterized protein. (535 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
CRHCorticotropin releasing hormone. (200 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
MIFUncharacterized protein. (114 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
ABCA2ATP binding cassette subfamily A member 2. (2425 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
PRAP1Uncharacterized protein. (145 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (742 aa)
EEPD1Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (959 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1078 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RXRARetinoid X receptor alpha. (471 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1521 aa)
APOA5Apolipoprotein A5. (366 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ACACBAcetyl-CoA carboxylase beta. (2438 aa)
SIRT1Sirtuin 1. (600 aa)
MSR1Macrophage scavenger receptor 1. (451 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
CRPPentaxin. (224 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
ENSCANP00000009431Uncharacterized protein. (233 aa)
NKX3-1NK3 homeobox 1. (232 aa)
TTC39BTetratricopeptide repeat domain 39B. (682 aa)
APOA2Apolipoprotein A2. (100 aa)
APOC4Uncharacterized protein. (127 aa)
KDM5BLysine demethylase 5B. (1487 aa)
ENSCANP00000011220Uncharacterized protein. (277 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (403 aa)
PTCH1Patched 1. (1449 aa)
C3Complement C3. (1508 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
TSPOUncharacterized protein. (65 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
ENSCANP00000013104ACB domain-containing protein. (78 aa)
DAB2DAB adaptor protein 2. (770 aa)
PON1Paraoxonase 1. (355 aa)
FITM1Fat storage inducing transmembrane protein 1. (292 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (383 aa)
ENSCANP00000013829PRELI/MSF1 domain-containing protein. (192 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (317 aa)
LOC105504501Uncharacterized protein. (210 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
TNFRSF11ATNF receptor superfamily member 11a. (712 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
SYKTyrosine-protein kinase. (635 aa)
CRHR1Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. (444 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ECRG4ECRG4 augurin precursor. (150 aa)
ENSCANP00000018729Uncharacterized protein. (108 aa)
ABCA5ATP binding cassette subfamily A member 5. (1642 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PLA2G4APhospholipase A2. (749 aa)
ABCA7ATP binding cassette subfamily A member 7. (2000 aa)
APOEApolipoprotein E. (189 aa)
VSTM2AV-set and transmembrane domain containing 2A. (310 aa)
RETNResistin. (108 aa)
ANXA2Annexin. (357 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (760 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
THBS1Thrombospondin 1. (1173 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (496 aa)
DISP3Dispatched RND transporter family member 3. (1390 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
LIPGLipase G, endothelial type. (500 aa)
DBIACB domain-containing protein. (148 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
ABCG8ATP binding cassette subfamily G member 8. (620 aa)
ENSCANP00000023654Uncharacterized protein. (281 aa)
DENND5BDENN domain containing 5B. (1254 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ENSCANP00000024205Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
ABCG1ATP binding cassette subfamily G member 1. (684 aa)
ABCA12ATP binding cassette subfamily A member 12. (2556 aa)
PPARAPeroxisome proliferator activated receptor alpha. (448 aa)
ENSCANP00000025796Uncharacterized protein. (269 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1154 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1141 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1123 aa)
SURF4Surfeit 4. (269 aa)
RENRenin; Belongs to the peptidase A1 family. (406 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
ERFEErythroferrone. (287 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (636 aa)
PRELID1PRELI domain containing 1. (208 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
GPS2G protein pathway suppressor 2. (327 aa)
FITM2Fat storage inducing transmembrane protein 2. (262 aa)
ABCA8ATP binding cassette subfamily A member 8. (1621 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
ABCA13ATP binding cassette subfamily A member 13. (5057 aa)
YJEFN3YjeF N-terminal domain containing 3. (291 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
TMF1TATA element modulatory factor 1. (943 aa)
ENSCANP00000034934SH2 domain-containing protein. (183 aa)
CIDEACell death inducing DFFA like effector a. (219 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
ENSCANP00000036145Uncharacterized protein. (268 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
PLIN5Perilipin; Belongs to the perilipin family. (466 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
ENSCANP00000038043Uncharacterized protein. (107 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (450 aa)
PLA2R1Phospholipase A2 receptor 1. (1473 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
PNPLA2Patatin like phospholipase domain containing 2. (428 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TTC39ATetratricopeptide repeat domain 39A. (612 aa)
C1QTNF1C1q and TNF related 1. (281 aa)
LRP1LDL receptor related protein 1. (4544 aa)
APOA1Apolipoprotein A1. (267 aa)
PLTPPhospholipid transfer protein. (493 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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