STRINGSTRING
LOC105526750 LOC105526750 LOC105526752 LOC105526752 LOC105526757 LOC105526757 ENSCANP00000006424 ENSCANP00000006424 KDM1A KDM1A HOXA11 HOXA11 ST18 ST18 RAD51 RAD51 SAPCD1 SAPCD1 LOC105517192 LOC105517192 LOC105508421 LOC105508421 ENSCANP00000020858 ENSCANP00000020858 ORC3 ORC3 TBX5 TBX5 POLD1 POLD1 LOC105519471 LOC105519471 BRF1 BRF1 ENSCANP00000018495 ENSCANP00000018495 MBTD1 MBTD1 CTU2 CTU2 TERB1 TERB1 GINS2 GINS2 IRF3 IRF3 GLYR1 GLYR1 ENSCANP00000025558 ENSCANP00000025558 LOC105517182 LOC105517182 CHTF8 CHTF8 NFE2 NFE2 RFXANK RFXANK VPS72 VPS72 LOC105520302 LOC105520302 WDHD1 WDHD1 YEATS4 YEATS4 GINS1 GINS1 LOC105524989 LOC105524989 H2AC20 H2AC20 H3F3B H3F3B H2AW H2AW POLA1 POLA1 POLD3 POLD3 TEN1 TEN1 ENSCANP00000032089 ENSCANP00000032089 GINS3 GINS3 SPHK2 SPHK2 MYOG MYOG CDC45 CDC45 TNP2 TNP2 ACD ACD PAX2 PAX2 SP8 SP8 HHEX HHEX TBX4 TBX4 SRGAP1 SRGAP1 HMGA2 HMGA2 PRKDC PRKDC ENSCANP00000014925 ENSCANP00000014925 GTF2B GTF2B HJURP HJURP H3F3A H3F3A TICRR TICRR ENSCANP00000033948 ENSCANP00000033948 ATF6B ATF6B ENSCANP00000034313 ENSCANP00000034313 LOC105517382 LOC105517382 ENSCANP00000000012 ENSCANP00000000012 POLD2 POLD2 ENSCANP00000000105 ENSCANP00000000105 H3C13 H3C13 RAG2 RAG2 H1-0 H1-0 ENSCANP00000000860 ENSCANP00000000860 ENSCANP00000001018 ENSCANP00000001018 KDM5A KDM5A RAG1 RAG1 ENSCANP00000001382 ENSCANP00000001382 LOC105520452 LOC105520452 H2BC5 H2BC5 LOC105526735 LOC105526735 H2AJ H2AJ BRD8 BRD8 KDM1B KDM1B LOC105526736 LOC105526736 LOC105510607 LOC105510607 ENSCANP00000002558 ENSCANP00000002558 H2AX H2AX LOC105507268 LOC105507268 LOC105513874 LOC105513874 LOC105513882 LOC105513882 H2AC14 H2AC14 LOC105526737 LOC105526737 LOC105526740 LOC105526740 H2BC1 H2BC1 H2BC3 H2BC3 LOC105509399 LOC105509399 LOC105526748 LOC105526748 LOC105506127 LOC105506127 LOC105513886 LOC105513886 MRGBP MRGBP LOC105526755 LOC105526755 ENSCANP00000004360 ENSCANP00000004360 EP300 EP300 ENSCANP00000014002 ENSCANP00000014002 CDC7 CDC7 PRIM2 PRIM2 ENSCANP00000012516 ENSCANP00000012516 SUB1 SUB1 SLF1 SLF1 THSD7B THSD7B NUPR1 NUPR1 ENSCANP00000010520 ENSCANP00000010520 ENSCANP00000010072 ENSCANP00000010072 CDT1 CDT1 RAD52 RAD52 GATA1 GATA1 MEAF6 MEAF6 LOC105519735 LOC105519735 RPA2 RPA2 NKX2-5 NKX2-5 DMRT2 DMRT2 RPA3 RPA3 NEIL2 NEIL2 TMEM232 TMEM232 MACROH2A1 MACROH2A1 POLD4 POLD4 ATRIP ATRIP ENSCANP00000039811 ENSCANP00000039811 POLA2 POLA2 GINS4 GINS4 CDC6 CDC6 SP9 SP9 LOC105521072 LOC105521072 TINF2 TINF2 PARP1 PARP1 PSIP1 PSIP1 LOC105513883 LOC105513883 LOC105513905 LOC105513905 ENSCANP00000004484 ENSCANP00000004484 LOC105506722 LOC105506722 NPM1 NPM1 DARS2 DARS2 ENSCANP00000005619 ENSCANP00000005619
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105526750Histone H3.1. (136 aa)
LOC105526752Histone H4. (103 aa)
LOC105526757Histone H4. (103 aa)
ENSCANP00000006424annotation not available (103 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (778 aa)
HOXA11Homeobox A11. (312 aa)
ST18ST18 C2H2C-type zinc finger transcription factor. (1047 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa)
SAPCD1Suppressor APC domain containing 1. (178 aa)
LOC105517192Uncharacterized protein. (280 aa)
LOC105508421TINF2_N domain-containing protein. (454 aa)
ENSCANP00000020858Uncharacterized protein. (185 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
TBX5T-box transcription factor 5. (518 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1012 aa)
LOC105519471Uncharacterized protein. (291 aa)
BRF1BRF1 RNA polymerase III transcription initiation factor subunit. (584 aa)
ENSCANP00000018495Uncharacterized protein. (57 aa)
MBTD1Mbt domain containing 1. (631 aa)
CTU2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family. (580 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (697 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
IRF3Interferon regulatory factor 3. (426 aa)
GLYR1Glyoxylate reductase 1 homolog. (553 aa)
ENSCANP00000025558Uncharacterized protein. (455 aa)
LOC105517182Uncharacterized protein. (291 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (260 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
LOC105520302Histone H3; Belongs to the histone H3 family. (136 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1044 aa)
YEATS4YEATS domain containing 4. (227 aa)
GINS1GINS complex subunit 1. (196 aa)
LOC105524989Histone H3; Belongs to the histone H3 family. (136 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H3F3BHistone domain-containing protein. (191 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
POLA1DNA polymerase. (1474 aa)
POLD3Uncharacterized protein. (454 aa)
TEN1Uncharacterized protein. (123 aa)
ENSCANP00000032089Uncharacterized protein. (120 aa)
GINS3GINS complex subunit 3. (255 aa)
SPHK2Sphingosine kinase 2. (658 aa)
MYOGMyogenin. (249 aa)
CDC45Cell division cycle 45. (598 aa)
TNP2Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (141 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (485 aa)
PAX2Paired box 2. (388 aa)
SP8Sp8 transcription factor. (407 aa)
HHEXHematopoietically expressed homeobox. (228 aa)
TBX4T-box transcription factor 4. (495 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
ENSCANP00000014925Histone H2B; Belongs to the histone H2B family. (121 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
HJURPHolliday junction recognition protein. (721 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1887 aa)
ENSCANP00000033948Homeobox domain-containing protein. (141 aa)
ATF6BActivating transcription factor 6 beta. (690 aa)
ENSCANP00000034313Protein kinase domain-containing protein. (543 aa)
LOC105517382Uncharacterized protein. (191 aa)
ENSCANP00000000012Nucleoplasmin domain-containing protein. (237 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
ENSCANP00000000105Histone H3; Belongs to the histone H3 family. (136 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
RAG2Recombination activating 2. (527 aa)
H1-0H1 histone family member 0. (194 aa)
ENSCANP00000000860annotation not available (136 aa)
ENSCANP00000001018annotation not available (136 aa)
KDM5ALysine demethylase 5A. (1690 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
ENSCANP00000001382Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105520452Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105526735Histone H3.1. (136 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
BRD8Bromodomain containing 8. (1235 aa)
KDM1BLysine demethylase 1B. (822 aa)
LOC105526736Histone H4. (103 aa)
LOC105510607Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCANP00000002558annotation not available (136 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC105507268Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105513874Histone H4. (103 aa)
LOC105513882Histone H4. (103 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC105526737Histone H4. (103 aa)
LOC105526740Histone H4. (103 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105509399Histone H3; Belongs to the histone H3 family. (135 aa)
LOC105526748Histone H4. (103 aa)
LOC105506127Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105513886Histone H3.1. (136 aa)
MRGBPUncharacterized protein. (75 aa)
LOC105526755Histone H3.1. (136 aa)
ENSCANP00000004360annotation not available (136 aa)
EP300E1A binding protein p300. (2409 aa)
ENSCANP00000014002Sld5 domain-containing protein. (160 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
ENSCANP00000012516H15 domain-containing protein. (202 aa)
SUB1PC4 domain-containing protein. (127 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
THSD7BThrombospondin type 1 domain containing 7B. (1151 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
ENSCANP00000010520PC4 domain-containing protein. (124 aa)
ENSCANP00000010072Uncharacterized protein. (153 aa)
CDT1Chromatin licensing and DNA replication factor 1. (470 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
GATA1GATA binding protein 1. (413 aa)
MEAF6MYST/Esa1 associated factor 6. (171 aa)
LOC105519735Chromosome 19 open reading frame 53. (99 aa)
RPA2Replication protein A2. (273 aa)
NKX2-5NK2 homeobox 5. (324 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (561 aa)
RPA3Replication protein A3. (121 aa)
NEIL2Nei like DNA glycosylase 2. (332 aa)
TMEM232Transmembrane protein 232. (567 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
POLD4Uncharacterized protein. (107 aa)
ATRIPATR interacting protein. (791 aa)
ENSCANP00000039811Uncharacterized protein. (263 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
SP9Sp9 transcription factor. (481 aa)
LOC105521072Uncharacterized protein. (280 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
PSIP1PC4 and SFRS1 interacting protein 1. (530 aa)
LOC105513883Histone H4. (103 aa)
LOC105513905Histone H4. (103 aa)
ENSCANP00000004484annotation not available (136 aa)
LOC105506722Histone H3; Belongs to the histone H3 family. (136 aa)
NPM1Nucleophosmin 1. (293 aa)
DARS2Aspartyl-tRNA synthetase 2, mitochondrial. (645 aa)
ENSCANP00000005619annotation not available (136 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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