STRINGSTRING
S100B S100B MAPK14 MAPK14 RPS6KA5 RPS6KA5 ENSCANP00000039354 ENSCANP00000039354 KHNYN KHNYN TBK1 TBK1 CREM CREM LOC105521899 LOC105521899 LOC105513286 LOC105513286 ENSCANP00000000485 ENSCANP00000000485 RPS27A RPS27A LRRC34 LRRC34 DUSP6 DUSP6 LOC105501700 LOC105501700 MAPK11 MAPK11 LRRC74A LRRC74A ENSCANP00000001894 ENSCANP00000001894 MAP2K7 MAP2K7 LOC105517114 LOC105517114 ENSCANP00000002557 ENSCANP00000002557 TIFA TIFA LOC105509542 LOC105509542 LOC105507704 LOC105507704 LOC105515808 LOC105515808 LRRC31 LRRC31 BIRC2 BIRC2 ENSCANP00000004194 ENSCANP00000004194 ENSCANP00000004477 ENSCANP00000004477 ATF2 ATF2 BIRC7 BIRC7 ENSCANP00000004759 ENSCANP00000004759 TONSL TONSL MAP3K7 MAP3K7 CHUK CHUK MAPK7 MAPK7 TANK TANK DUSP7 DUSP7 MEF2C MEF2C ENSCANP00000006830 ENSCANP00000006830 MAP2K6 MAP2K6 ELK1 ELK1 ATF1 ATF1 NFKBIA NFKBIA TAB3 TAB3 PPP2R5D PPP2R5D ENSCANP00000007912 ENSCANP00000007912 N4BP1 N4BP1 RIPK1 RIPK1 LOC105508581 LOC105508581 LOC105510963 LOC105510963 ALPK1 ALPK1 NOD1 NOD1 CUL1 CUL1 UBE2D1 UBE2D1 MAPK9 MAPK9 IKBKB IKBKB BTRC BTRC ENSCANP00000011220 ENSCANP00000011220 UBA52 UBA52 LOC105523183 LOC105523183 ENSCANP00000012071 ENSCANP00000012071 CREB5 CREB5 FOSL2 FOSL2 LRRC14 LRRC14 CASP8 CASP8 UBE2D2 UBE2D2 USP14 USP14 FADD FADD CREB1 CREB1 VWC2 VWC2 CCDC71L CCDC71L RPS6KA1 RPS6KA1 MAPK3 MAPK3 TRAF5 TRAF5 NKIRAS1 NKIRAS1 LOC105503496 LOC105503496 MAP3K20 MAP3K20 MAP2K3 MAP2K3 DUSP4 DUSP4 RELCH RELCH TAB1 TAB1 LOC105520631 LOC105520631 TRAF6 TRAF6 NFKB2 NFKB2 TNIP2 TNIP2 ENSCANP00000018891 ENSCANP00000018891 MAPK10 MAPK10 FOS FOS IRAK2 IRAK2 NLRP6 NLRP6 IRAK1 IRAK1 MAP3K8 MAP3K8 LY96 LY96 ENSCANP00000019642 ENSCANP00000019642 LOC105507991 LOC105507991 NFKBIB NFKBIB MAPK8 MAPK8 NLRP9 NLRP9 UBE2N UBE2N DUSP3 DUSP3 MAP2K4 MAP2K4 ENSCANP00000022288 ENSCANP00000022288 NAIP NAIP MEF2A MEF2A LRRC74B LRRC74B IRF3 IRF3 NFKB1 NFKB1 AGER AGER SARM1 SARM1 BIRC3 BIRC3 RPS6KA3 RPS6KA3 NLRP13 NLRP13 ENSCANP00000025746 ENSCANP00000025746 ENSCANP00000025796 ENSCANP00000025796 ENSCANP00000025859 ENSCANP00000025859 MAPKAPK3 MAPKAPK3 TAB2 TAB2 MAPK1 MAPK1 MAPK15 MAPK15 PPP2CB PPP2CB TICAM1 TICAM1 SKP1 SKP1 LOC105525747 LOC105525747 IKBKE IKBKE PPP4R1 PPP4R1 TRAF3 TRAF3 CD14 CD14 TLR4 TLR4 TP53 TP53 TICAM2 TICAM2 IRF7 IRF7 UBE2NL UBE2NL PPP2CA PPP2CA NOD2 NOD2 PPP2R1A PPP2R1A RIPK2 RIPK2 FBXW11 FBXW11 LRRC45 LRRC45 JUN JUN APP APP RIPK3 RIPK3 RELA RELA PTPN11 PTPN11 LRRC71 LRRC71 LOC105504558 LOC105504558 ENSCANP00000033944 ENSCANP00000033944 MAPKAPK2 MAPKAPK2 NLRC5 NLRC5 ENSCANP00000034934 ENSCANP00000034934 MAP2K1 MAP2K1 VRK3 VRK3 PPP2R1B PPP2R1B HMGB1 HMGB1 ENSCANP00000036145 ENSCANP00000036145 IKBKG IKBKG NLRX1 NLRX1 PPP4R4 PPP4R4 ATF7 ATF7 RPS6KA2 RPS6KA2 LOC105508579 LOC105508579 LOC105508582 LOC105508582 TRAF2 TRAF2 FNBP4 FNBP4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
S100BS_100 domain-containing protein; Belongs to the S-100 family. (94 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
KHNYNKH and NYN domain containing. (678 aa)
TBK1TANK binding kinase 1. (713 aa)
CREMcAMP responsive element modulator. (322 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
LOC105513286UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
LRRC34Leucine rich repeat containing 34. (415 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LOC105501700UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
ENSCANP00000001894Uncharacterized protein. (215 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
ENSCANP00000002557Uncharacterized protein. (535 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
LOC105509542UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC105507704ETS domain-containing protein. (403 aa)
LOC105515808UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
LRRC31Leucine rich repeat containing 31. (552 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ENSCANP00000004194CCHC NOA-type domain-containing protein. (374 aa)
ENSCANP00000004477Uncharacterized protein. (192 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
TONSLTonsoku like, DNA repair protein. (1240 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ELK1ETS domain-containing protein. (428 aa)
ATF1Activating transcription factor 1. (270 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
N4BP1NEDD4 binding protein 1. (829 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (625 aa)
LOC105508581Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (121 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
ALPK1Alpha kinase 1. (1244 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (527 aa)
ENSCANP00000011220Uncharacterized protein. (277 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
ENSCANP00000012071Uncharacterized protein. (157 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (309 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
UBE2D2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (490 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (200 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
CCDC71LUncharacterized protein. (307 aa)
RPS6KA1Ribosomal protein S6 kinase. (728 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LOC105520631UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TNIP2TNFAIP3 interacting protein 2. (322 aa)
ENSCANP00000018891Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
NLRP6NLR family pyrin domain containing 6. (1041 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (648 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
LY96Lymphocyte antigen 96. (160 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
LOC105507991Uncharacterized protein. (869 aa)
NFKBIBNFKB inhibitor beta. (321 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NLRP9NLR family pyrin domain containing 9. (876 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
NAIPNLR family apoptosis inhibitory protein. (1369 aa)
MEF2AMyocyte enhancer factor 2A. (512 aa)
LRRC74BLeucine rich repeat containing 74B. (366 aa)
IRF3Interferon regulatory factor 3. (426 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
SARM1Sterile alpha and TIR motif containing 1. (594 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
NLRP13NLR family pyrin domain containing 13. (1021 aa)
ENSCANP00000025746Uncharacterized protein; Belongs to the SKP1 family. (167 aa)
ENSCANP00000025796Uncharacterized protein. (269 aa)
ENSCANP00000025859UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK15Mitogen-activated protein kinase. (545 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
TICAM1Toll like receptor adaptor molecule 1. (517 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
LOC105525747UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (636 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (923 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
IRF7Interferon regulatory factor 7. (503 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (594 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
APPAmyloid beta precursor protein. (770 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
LRRC71Leucine rich repeat containing 71. (559 aa)
LOC105504558UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
ENSCANP00000033944Uncharacterized protein; Belongs to the SKP1 family. (131 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (431 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
ENSCANP00000034934SH2 domain-containing protein. (183 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VRK3VRK serine/threonine kinase 3. (475 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
HMGB1Uncharacterized protein. (206 aa)
ENSCANP00000036145Uncharacterized protein. (268 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
NLRX1NLR family member X1. (972 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (854 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
LOC105508579Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
LOC105508582Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
FNBP4Formin binding protein 4. (950 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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