STRINGSTRING
CHD4 CHD4 DUSP6 DUSP6 CREM CREM NKPD1 NKPD1 JUNB JUNB ADCYAP1 ADCYAP1 ERAS ERAS F3 F3 MAPK11 MAPK11 ENSCANP00000002557 ENSCANP00000002557 NAB1 NAB1 LOC105507704 LOC105507704 PCSK4 PCSK4 CDK5R1 CDK5R1 FNDC3A FNDC3A ARC ARC SHC4 SHC4 ATF2 ATF2 HRAS HRAS MAPK7 MAPK7 IRS1 IRS1 KIDINS220 KIDINS220 DOCK3 DOCK3 FURIN FURIN NTF4 NTF4 KRAS KRAS PTPRO PTPRO NTF3 NTF3 DUSP7 DUSP7 MEF2C MEF2C ELK1 ELK1 ATF1 ATF1 NGF NGF PPP2R5D PPP2R5D RHOA RHOA YWHAB YWHAB RAPGEF1 RAPGEF1 DNM3 DNM3 NTRK2 NTRK2 FRS3 FRS3 LOC105510963 LOC105510963 ENSCANP00000009565 ENSCANP00000009565 AP2M1 AP2M1 PTPRS PTPRS ENSCANP00000011220 ENSCANP00000011220 TIAM1 TIAM1 PLCG1 PLCG1 SH3GL3 SH3GL3 TPH1 TPH1 MAP2K2 MAP2K2 CREB1 CREB1 PCSK6 PCSK6 MAPK12 MAPK12 ADORA2A ADORA2A EP300 EP300 DNAL4 DNAL4 LOC105504658 LOC105504658 RPS6KA1 RPS6KA1 MAPK3 MAPK3 EGR3 EGR3 BDNF BDNF PIK3CA PIK3CA RIT2 RIT2 DUSP4 DUSP4 RELCH RELCH CRK CRK FYN FYN RALA RALA ID3 ID3 FOS FOS TRIB1 TRIB1 NELFB NELFB NAB2 NAB2 LOC105507991 LOC105507991 ENSCANP00000019829 ENSCANP00000019829 CDK5 CDK5 RRAD RRAD ENSCANP00000020706 ENSCANP00000020706 TRIB2 TRIB2 DUSP3 DUSP3 PIK3R1 PIK3R1 AP2S1 AP2S1 STAT3 STAT3 RIT1 RIT1 CSDE1 CSDE1 MEF2A MEF2A SHC1 SHC1 LYL1 LYL1 SH3GL2 SH3GL2 MEF2D MEF2D SHC2 SHC2 MAP2K5 MAP2K5 RAP1A RAP1A RPS6KA3 RPS6KA3 ASCL1 ASCL1 RALGDS RALGDS ENSCANP00000025796 ENSCANP00000025796 MAPKAPK3 MAPKAPK3 SRF SRF MAPK1 MAPK1 AP2B1 AP2B1 SHC3 SHC3 MAPK15 MAPK15 SGK1 SGK1 PPP2CB PPP2CB PPP4R1 PPP4R1 DNM2 DNM2 LOC105501272 LOC105501272 CLTC CLTC PPP2CA PPP2CA NTRK1 NTRK1 PPP2R1A PPP2R1A ENSCANP00000029966 ENSCANP00000029966 PIK3CB PIK3CB ENSCANP00000030238 ENSCANP00000030238 CRKL CRKL NTRK3 NTRK3 ID2 ID2 EGR2 EGR2 EGR4 EGR4 DNM1 DNM1 PIK3R2 PIK3R2 PCSK5 PCSK5 SOS1 SOS1 PTPN11 PTPN11 MAPK13 MAPK13 AP2A2 AP2A2 FOSL1 FOSL1 MAPKAPK2 MAPKAPK2 REST REST EGR1 EGR1 ENSCANP00000034934 ENSCANP00000034934 MAP2K1 MAP2K1 VRK3 VRK3 CLTA CLTA TCF12 TCF12 FOSB FOSB PPP2R1B PPP2R1B FNDC3B FNDC3B BRAF BRAF GRIN2B GRIN2B ENSCANP00000036145 ENSCANP00000036145 GAB1 GAB1 PPP4R4 PPP4R4 ID1 ID1 AP2A1 AP2A1 RPS6KA2 RPS6KA2 RALB RALB FNBP4 FNBP4 FRS2 FRS2 ENSCANP00000039354 ENSCANP00000039354 RPS6KA5 RPS6KA5 MAPK14 MAPK14 SRC SRC GRB2 GRB2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHD4Uncharacterized protein. (1882 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CREMcAMP responsive element modulator. (322 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (609 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
ERASES cell expressed Ras. (233 aa)
F3Coagulation factor III, tissue factor. (296 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
ENSCANP00000002557Uncharacterized protein. (535 aa)
NAB1NGFI-A binding protein 1. (487 aa)
LOC105507704ETS domain-containing protein. (403 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (707 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
SHC4SHC adaptor protein 4. (630 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
KIDINS220Kinase D interacting substrate 220. (1777 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2012 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ELK1ETS domain-containing protein. (428 aa)
ATF1Activating transcription factor 1. (270 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
RHOARas homolog family member A. (193 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
ENSCANP00000009565Uncharacterized protein. (651 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1797 aa)
ENSCANP00000011220Uncharacterized protein. (277 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (354 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (928 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
EP300E1A binding protein p300. (2409 aa)
DNAL4Dynein light chain. (105 aa)
LOC105504658Uncharacterized protein. (571 aa)
RPS6KA1Ribosomal protein S6 kinase. (728 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
EGR3Early growth response 3. (387 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RIT2Uncharacterized protein. (162 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
FYNTyrosine-protein kinase. (537 aa)
RALARAS like proto-oncogene A. (206 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TRIB1Tribbles pseudokinase 1. (206 aa)
NELFBNegative elongation factor complex member B. (573 aa)
NAB2NGFI-A binding protein 2. (525 aa)
LOC105507991Uncharacterized protein. (869 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
ENSCANP00000020706Protein kinase domain-containing protein. (281 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
RIT1Ras like without CAAX 1. (236 aa)
CSDE1Uncharacterized protein. (844 aa)
MEF2AMyocyte enhancer factor 2A. (512 aa)
SHC1SHC adaptor protein 1. (584 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
SHC2SHC adaptor protein 2. (381 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (231 aa)
RALGDSUncharacterized protein. (839 aa)
ENSCANP00000025796Uncharacterized protein. (269 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
SRFSerum response factor. (406 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
AP2B1AP complex subunit beta. (951 aa)
SHC3SHC adaptor protein 3. (517 aa)
MAPK15Mitogen-activated protein kinase. (545 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (923 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (840 aa)
LOC105501272Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (222 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (594 aa)
ENSCANP00000029966B2-adapt-app_C domain-containing protein. (214 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
ENSCANP00000030238Uncharacterized protein. (315 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
NTRK3Tyrosine-protein kinase receptor. (865 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
EGR2Early growth response 2. (476 aa)
EGR4Early growth response 4. (589 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (774 aa)
PIK3R2Uncharacterized protein. (601 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1758 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (950 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (431 aa)
RESTRE1 silencing transcription factor. (1096 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
ENSCANP00000034934SH2 domain-containing protein. (183 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VRK3VRK serine/threonine kinase 3. (475 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (237 aa)
TCF12Transcription factor 12. (706 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (747 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
ENSCANP00000036145Uncharacterized protein. (268 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (854 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (953 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
RALBRAS like proto-oncogene B. (212 aa)
FNBP4Formin binding protein 4. (950 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SRCTyrosine-protein kinase. (458 aa)
GRB2Uncharacterized protein. (156 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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