STRINGSTRING
MAPK3 MAPK3 MAPK14 MAPK14 RPS6KA5 RPS6KA5 ENSCANP00000039354 ENSCANP00000039354 KHNYN KHNYN FNBP4 FNBP4 TRAF2 TRAF2 LOC105508582 LOC105508582 LOC105508579 LOC105508579 RPS6KA2 RPS6KA2 ATF7 ATF7 PPP4R4 PPP4R4 NLRX1 NLRX1 IKBKG IKBKG HMGB1 HMGB1 PPP2R1B PPP2R1B VRK3 VRK3 MAP2K1 MAP2K1 NLRC5 NLRC5 MAPKAPK2 MAPKAPK2 ENSCANP00000033944 ENSCANP00000033944 LOC105504558 LOC105504558 LRRC71 LRRC71 RBSN RBSN RELA RELA S100B S100B APP APP JUN JUN LRRC45 LRRC45 FBXW11 FBXW11 RIPK2 RIPK2 MYD88 MYD88 PELI2 PELI2 TLR9 TLR9 IRAK4 IRAK4 PPP2R1A PPP2R1A NOD2 NOD2 PPP2CA PPP2CA UBE2NL UBE2NL IRF7 IRF7 TICAM2 TICAM2 TP53 TP53 TLR4 TLR4 CD14 CD14 PPP4R1 PPP4R1 LOC105525747 LOC105525747 SKP1 SKP1 TICAM1 TICAM1 PPP2CB PPP2CB MAPK15 MAPK15 PIK3C3 PIK3C3 MAPK1 MAPK1 TAB2 TAB2 MAP3K1 MAP3K1 MAPKAPK3 MAPKAPK3 ENSCANP00000025859 ENSCANP00000025859 ENSCANP00000025746 ENSCANP00000025746 NLRP13 NLRP13 RPS6KA3 RPS6KA3 AGER AGER NFKB1 NFKB1 LRRC74B LRRC74B MEF2A MEF2A ENSCANP00000022288 ENSCANP00000022288 MAP2K4 MAP2K4 DUSP3 DUSP3 UBE2N UBE2N NLRP9 NLRP9 MAPK8 MAPK8 NFKBIB NFKBIB LOC105507991 LOC105507991 ENSCANP00000019642 ENSCANP00000019642 LY96 LY96 MAP3K8 MAP3K8 IRAK1 IRAK1 NLRP6 NLRP6 IRAK2 IRAK2 FOS FOS MAPK10 MAPK10 ENSCANP00000018891 ENSCANP00000018891 TNIP2 TNIP2 PELI1 PELI1 NFKB2 NFKB2 TRAF6 TRAF6 LOC105520631 LOC105520631 TAB1 TAB1 RELCH RELCH DUSP4 DUSP4 MAP2K3 MAP2K3 MAP3K20 MAP3K20 LOC105503496 LOC105503496 NKIRAS1 NKIRAS1 RPS6KA1 RPS6KA1 CCDC71L CCDC71L VWC2 VWC2 CREB1 CREB1 USP14 USP14 CASP8 CASP8 LRRC14 LRRC14 FOSL2 FOSL2 CREB5 CREB5 ENSCANP00000012071 ENSCANP00000012071 LOC105523183 LOC105523183 PELI3 PELI3 UBA52 UBA52 BTRC BTRC IKBKB IKBKB MAPK9 MAPK9 CUL1 CUL1 NOD1 NOD1 ALPK1 ALPK1 LOC105510963 LOC105510963 ECSIT ECSIT LOC105508581 LOC105508581 N4BP1 N4BP1 ENSCANP00000007912 ENSCANP00000007912 EEA1 EEA1 PPP2R5D PPP2R5D TAB3 TAB3 NFKBIA NFKBIA ATF1 ATF1 ELK1 ELK1 MAP2K6 MAP2K6 ENSCANP00000006830 ENSCANP00000006830 MEF2C MEF2C DUSP7 DUSP7 MAPK7 MAPK7 CHUK CHUK MAP3K7 MAP3K7 TONSL TONSL ENSCANP00000004759 ENSCANP00000004759 ATF2 ATF2 ENSCANP00000004477 ENSCANP00000004477 ENSCANP00000004194 ENSCANP00000004194 LRRC31 LRRC31 LOC105515808 LOC105515808 LOC105507704 LOC105507704 PIK3R4 PIK3R4 LOC105509542 LOC105509542 TIFA TIFA LOC105517114 LOC105517114 MAP2K7 MAP2K7 ENSCANP00000001894 ENSCANP00000001894 LRRC74A LRRC74A TLR7 TLR7 MAPK11 MAPK11 LOC105501700 LOC105501700 CREM CREM LOC105521899 LOC105521899 LOC105513286 LOC105513286 ENSCANP00000000485 ENSCANP00000000485 RPS27A RPS27A LRRC34 LRRC34 DUSP6 DUSP6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
KHNYNKH and NYN domain containing. (678 aa)
FNBP4Formin binding protein 4. (950 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
LOC105508582Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
LOC105508579Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (854 aa)
NLRX1NLR family member X1. (972 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
HMGB1Uncharacterized protein. (206 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
VRK3VRK serine/threonine kinase 3. (475 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (431 aa)
ENSCANP00000033944Uncharacterized protein; Belongs to the SKP1 family. (131 aa)
LOC105504558UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
LRRC71Leucine rich repeat containing 71. (559 aa)
RBSNRabenosyn, RAB effector. (785 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
S100BS_100 domain-containing protein; Belongs to the S-100 family. (94 aa)
APPAmyloid beta precursor protein. (770 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (394 aa)
TLR9TIR domain-containing protein. (1033 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (438 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (594 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
IRF7Interferon regulatory factor 7. (503 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (923 aa)
LOC105525747UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
TICAM1Toll like receptor adaptor molecule 1. (517 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
MAPK15Mitogen-activated protein kinase. (545 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1356 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
ENSCANP00000025859UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
ENSCANP00000025746Uncharacterized protein; Belongs to the SKP1 family. (167 aa)
NLRP13NLR family pyrin domain containing 13. (1021 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
LRRC74BLeucine rich repeat containing 74B. (366 aa)
MEF2AMyocyte enhancer factor 2A. (512 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
NLRP9NLR family pyrin domain containing 9. (876 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NFKBIBNFKB inhibitor beta. (321 aa)
LOC105507991Uncharacterized protein. (869 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
LY96Lymphocyte antigen 96. (160 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (648 aa)
NLRP6NLR family pyrin domain containing 6. (1041 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
ENSCANP00000018891Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
TNIP2TNFAIP3 interacting protein 2. (322 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LOC105520631UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
RPS6KA1Ribosomal protein S6 kinase. (728 aa)
CCDC71LUncharacterized protein. (307 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (490 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (309 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ENSCANP00000012071Uncharacterized protein. (157 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (527 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
ALPK1Alpha kinase 1. (1244 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
ECSITECSIT signalling integrator. (432 aa)
LOC105508581Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (121 aa)
N4BP1NEDD4 binding protein 1. (829 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
EEA1Early endosome antigen 1. (1411 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ATF1Activating transcription factor 1. (270 aa)
ELK1ETS domain-containing protein. (428 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TONSLTonsoku like, DNA repair protein. (1240 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSCANP00000004477Uncharacterized protein. (192 aa)
ENSCANP00000004194CCHC NOA-type domain-containing protein. (374 aa)
LRRC31Leucine rich repeat containing 31. (552 aa)
LOC105515808UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
LOC105507704ETS domain-containing protein. (403 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
LOC105509542UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
ENSCANP00000001894Uncharacterized protein. (215 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
LOC105501700UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
CREMcAMP responsive element modulator. (322 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
LOC105513286UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
LRRC34Leucine rich repeat containing 34. (415 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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