STRINGSTRING
HDAC10 HDAC10 HDAC11 HDAC11 CREBBP CREBBP ADAM10 ADAM10 MIB1 MIB1 HDAC1 HDAC1 MYC MYC TLE4 TLE4 HIF1A HIF1A SKP1 SKP1 HDAC9 HDAC9 HDAC6 HDAC6 TLE1 TLE1 NOTCH1 NOTCH1 PSENEN PSENEN DLL1 DLL1 JAG1 JAG1 PSEN1 PSEN1 ENSCANP00000025746 ENSCANP00000025746 MAMLD1 MAMLD1 TBL1XR1 TBL1XR1 HDAC2 HDAC2 DTX2 DTX2 TBL1X TBL1X APH1A APH1A HES1 HES1 ENSCANP00000022288 ENSCANP00000022288 NCOR2 NCOR2 TLE3 TLE3 HEY2 HEY2 ENSCANP00000019642 ENSCANP00000019642 ENSCANP00000018891 ENSCANP00000018891 APH1B APH1B ARRB1 ARRB1 CDK8 CDK8 NCOR1 NCOR1 HDAC4 HDAC4 LOC105503496 LOC105503496 NBEA NBEA JAG2 JAG2 HDAC3 HDAC3 SNW1 SNW1 MAML1 MAML1 EP300 EP300 DLL4 DLL4 HDAC5 HDAC5 LOC105516286 LOC105516286 LOC105523183 LOC105523183 UBA52 UBA52 KAT2A KAT2A DTX4 DTX4 CUL1 CUL1 MAML2 MAML2 ADAM17 ADAM17 CNTN1 CNTN1 ENSCANP00000007912 ENSCANP00000007912 MIB2 MIB2 CCNC CCNC DTX1 DTX1 ENSCANP00000004759 ENSCANP00000004759 ENSCANP00000003880 ENSCANP00000003880 RBX1 RBX1 LOC105527037 LOC105527037 HDAC7 HDAC7 ITCH ITCH LOC105517114 LOC105517114 RBPJ RBPJ ARRB2 ARRB2 HEY1 HEY1 HDAC8 HDAC8 LOC105521899 LOC105521899 ENSCANP00000000485 ENSCANP00000000485 RPS27A RPS27A NEURL1B NEURL1B DNER DNER DLK1 DLK1 PSEN2 PSEN2 KAT2B KAT2B TLE2 TLE2 NCSTN NCSTN NUMB NUMB ENSCANP00000033944 ENSCANP00000033944 FBXW7 FBXW7 LRBA LRBA HEYL HEYL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC10Histone deacetylase 10. (671 aa)
HDAC11Histone deacetylase 11. (359 aa)
CREBBPCREB binding protein. (2117 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (476 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
TLE4TLE family member 4, transcriptional corepressor. (790 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
HDAC6Histone deacetylase 6. (1217 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
NOTCH1Notch receptor 1. (2559 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
ENSCANP00000025746Uncharacterized protein; Belongs to the SKP1 family. (167 aa)
MAMLD1Mastermind like domain containing 1. (990 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
TBL1XTransducin beta like 1 X-linked. (575 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
HES1Hes family bHLH transcription factor 1. (253 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
TLE3TLE family member 3, transcriptional corepressor. (782 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
ENSCANP00000018891Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (219 aa)
ARRB1Arrestin beta 1. (418 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1090 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
NBEANeurobeachin. (2903 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
SNW1SNW domain containing 1. (571 aa)
MAML1Mastermind like transcriptional coactivator 1. (924 aa)
EP300E1A binding protein p300. (2409 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1125 aa)
LOC105516286Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (449 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
DTX4Deltex E3 ubiquitin ligase 4. (558 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
MAML2Mastermind like transcriptional coactivator 2. (1156 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
CNTN1Contactin 1. (1018 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (939 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
DTX1Deltex E3 ubiquitin ligase 1. (552 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
ENSCANP00000003880Hist_deacetyl domain-containing protein. (281 aa)
RBX1Ring-box 1. (108 aa)
LOC105527037Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (459 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1002 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (524 aa)
ARRB2Arrestin beta 2. (492 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (324 aa)
DNERDelta/notch like EGF repeat containing. (687 aa)
DLK1Delta like non-canonical Notch ligand 1. (381 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (778 aa)
TLE2TLE family member 2, transcriptional corepressor. (653 aa)
NCSTNNicastrin. (709 aa)
NUMBNUMB endocytic adaptor protein. (652 aa)
ENSCANP00000033944Uncharacterized protein; Belongs to the SKP1 family. (131 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
LRBALPS responsive beige-like anchor protein. (2852 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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