58 items (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1052 aa)
	CBL	Cbl proto-oncogene. (888 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1127 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1510 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
	FBN1	Fibrillin 1. (2816 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (306 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SMURF1	E3 ubiquitin-protein ligase. (763 aa)
	SMURF2	E3 ubiquitin-protein ligase. (734 aa)
	ZFYVE9	Zinc finger FYVE domain-containing protein. (1409 aa)
	LTBP4	Latent transforming growth factor beta binding protein 4. (1599 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1131 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	ENSCANP00000022288	Ubiquitin-like domain-containing protein. (79 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (792 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ENSCANP00000019642	Ribosomal_S27 domain-containing protein. (93 aa)
	STRAP	Serine/threonine kinase receptor associated protein. (363 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (259 aa)
	LOC105503496	Ubiquitin-like domain-containing protein. (147 aa)
	FKBP1A	Peptidylprolyl isomerase. (127 aa)
	USP15	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
	NEDD8	NEDD8 ubiquitin like modifier. (82 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	ENSCANP00000012853	C2 domain-containing protein. (51 aa)
	LOC105523183	Ubiquitin-like domain-containing protein. (77 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	XPO1	Exportin 1. (1032 aa)
	LTBP2	Latent transforming growth factor beta binding protein 2. (1821 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (746 aa)
	MTMR4	Myotubularin related protein 4. (1195 aa)
	PPP1R15A	Protein phosphatase 1 regulatory subunit 15A. (676 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
	ENSCANP00000007912	Ubiquitin-like domain-containing protein. (121 aa)
	ENSCANP00000007443	Peptidylprolyl isomerase. (127 aa)
	SMAD7	Mothers against decapentaplegic homolog. (431 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	ENSCANP00000005988	Peptidylprolyl isomerase. (107 aa)
	ENSCANP00000004759	Ubiquitin-like domain-containing protein. (147 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (707 aa)
	ENSCANP00000003071	SER_THR_PHOSPHATASE domain-containing protein. (146 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (250 aa)
	LOC105517114	Ubiquitin-like domain-containing protein. (156 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	LOC105521899	Ubiquitin-like domain-containing protein. (146 aa)
	ENSCANP00000000485	Ubiquitin-like domain-containing protein. (72 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (769 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAMBI	SMAD2	ENSCANP00000001308	ENSCANP00000036850	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.521
BAMBI	SMAD3	ENSCANP00000001308	ENSCANP00000000895	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.514
BAMBI	SMAD4	ENSCANP00000001308	ENSCANP00000029295	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.600
BAMBI	SMAD7	ENSCANP00000001308	ENSCANP00000006477	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.847
BAMBI	TGFB1	ENSCANP00000001308	ENSCANP00000008792	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.706
BAMBI	TGFBR1	ENSCANP00000001308	ENSCANP00000029823	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.909
BAMBI	TGFBR2	ENSCANP00000001308	ENSCANP00000004177	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.643
CBL	ENSCANP00000000485	ENSCANP00000038803	ENSCANP00000000485	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.707
CBL	ENSCANP00000004759	ENSCANP00000038803	ENSCANP00000004759	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.707
CBL	ENSCANP00000007912	ENSCANP00000038803	ENSCANP00000007912	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.707
CBL	ENSCANP00000012853	ENSCANP00000038803	ENSCANP00000012853	Cbl proto-oncogene.	C2 domain-containing protein.	0.699
CBL	ENSCANP00000019642	ENSCANP00000038803	ENSCANP00000019642	Cbl proto-oncogene.	Ribosomal_S27 domain-containing protein.	0.772
CBL	ENSCANP00000022288	ENSCANP00000038803	ENSCANP00000022288	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.847
CBL	LOC105503496	ENSCANP00000038803	ENSCANP00000016322	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.772
CBL	LOC105517114	ENSCANP00000038803	ENSCANP00000002234	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.772
CBL	LOC105521899	ENSCANP00000038803	ENSCANP00000000599	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.707
CBL	LOC105523183	ENSCANP00000038803	ENSCANP00000011982	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.946
CBL	NEDD4L	ENSCANP00000038803	ENSCANP00000024635	Cbl proto-oncogene.	NEDD4 like E3 ubiquitin protein ligase.	0.849
CBL	NEDD8	ENSCANP00000038803	ENSCANP00000013546	Cbl proto-oncogene.	NEDD8 ubiquitin like modifier.	0.638
CBL	RPS27A	ENSCANP00000038803	ENSCANP00000000407	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.772