STRINGSTRING
ENSCANP00000019642 ENSCANP00000019642 APH1A APH1A PSEN1 PSEN1 JAG1 JAG1 DLL1 DLL1 PSENEN PSENEN MIB1 MIB1 ADAM10 ADAM10 NCSTN NCSTN PSEN2 PSEN2 NEURL1B NEURL1B NOTCH2 NOTCH2 RPS27A RPS27A CNTN1 CNTN1 UBA52 UBA52 DLL4 DLL4 JAG2 JAG2 LOC105503496 LOC105503496 APH1B APH1B MIB2 MIB2 LOC105517114 LOC105517114
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
NCSTNNicastrin. (709 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (324 aa)
NOTCH2Notch receptor 2. (2471 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CNTN1Contactin 1. (1018 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (219 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (939 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.