STRINGSTRING
LOC105507704 LOC105507704 DUSP6 DUSP6 CREM CREM MAPK11 MAPK11 ATF2 ATF2 MAPK7 MAPK7 DUSP7 DUSP7 MEF2C MEF2C ELK1 ELK1 ATF1 ATF1 PPP2R5D PPP2R5D LOC105510963 LOC105510963 MAPK9 MAPK9 CREB5 CREB5 FOSL2 FOSL2 CREB1 CREB1 RPS6KA1 RPS6KA1 MAPK3 MAPK3 DUSP4 DUSP4 RELCH RELCH MAPK10 MAPK10 FOS FOS LOC105507991 LOC105507991 MAPK8 MAPK8 DUSP3 DUSP3 MEF2A MEF2A RPS6KA3 RPS6KA3 MAPK1 MAPK1 MAPK15 MAPK15 PPP2CB PPP2CB PPP4R1 PPP4R1 PPP2CA PPP2CA PPP2R1A PPP2R1A JUN JUN MAPKAPK2 MAPKAPK2 VRK3 VRK3 PPP2R1B PPP2R1B PPP4R4 PPP4R4 ATF7 ATF7 RPS6KA2 RPS6KA2 FNBP4 FNBP4 RPS6KA5 RPS6KA5 MAPK14 MAPK14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105507704ETS domain-containing protein. (403 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CREMcAMP responsive element modulator. (322 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ELK1ETS domain-containing protein. (428 aa)
ATF1Activating transcription factor 1. (270 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (309 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RPS6KA1Ribosomal protein S6 kinase. (728 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC105507991Uncharacterized protein. (869 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
MEF2AMyocyte enhancer factor 2A. (512 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK15Mitogen-activated protein kinase. (545 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (923 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (594 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (431 aa)
VRK3VRK serine/threonine kinase 3. (475 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (854 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
FNBP4Formin binding protein 4. (950 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.