STRINGSTRING
CASP8 CASP8 FADD FADD LOC105500565 LOC105500565 TNFRSF10A TNFRSF10A LOC105503496 LOC105503496 OGT OGT TNFRSF10B TNFRSF10B PELI1 PELI1 PDCD6IP PDCD6IP PRKN PRKN ENSCANP00000004759 ENSCANP00000004759 TNFSF10 TNFSF10 BIRC7 BIRC7 ENSCANP00000004166 ENSCANP00000004166 BIRC2 BIRC2 STUB1 STUB1 ITCH ITCH LOC105517114 LOC105517114 SDCBP SDCBP FLOT1 FLOT1 ENSCANP00000019642 ENSCANP00000019642 TRADD TRADD ENSCANP00000022288 ENSCANP00000022288 NAIP NAIP ENSCANP00000024192 ENSCANP00000024192 BIRC3 BIRC3 CFLAR CFLAR UBE2L5 UBE2L5 LOC105502431 LOC105502431 RIPK3 RIPK3 TRAF2 TRAF2 UBA52 UBA52 HSP90AA1 HSP90AA1 RIPK1 RIPK1 FASLG FASLG ENSCANP00000007912 ENSCANP00000007912 ENSCANP00000006850 ENSCANP00000006850 FLOT2 FLOT2 XIAP XIAP LOC105509062 LOC105509062 LOC105523183 LOC105523183 LOC105521899 LOC105521899 ENSCANP00000000485 ENSCANP00000000485 RPS27A RPS27A CDC37 CDC37 FAS FAS LOC105515285 LOC105515285
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (200 aa)
LOC105500565TPR_REGION domain-containing protein. (1721 aa)
TNFRSF10ATNF receptor superfamily member 10a. (469 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
TNFRSF10BTNF receptor superfamily member 10b. (444 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
PDCD6IPBRO1 domain-containing protein. (903 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
ENSCANP00000004166PDZ domain-containing protein. (294 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
STUB1STIP1 homology and U-box containing protein 1. (250 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
SDCBPSyndecan binding protein. (318 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (372 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
NAIPNLR family apoptosis inhibitory protein. (1369 aa)
ENSCANP00000024192HATPase_c domain-containing protein. (669 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (452 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
LOC105502431Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (821 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (625 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
ENSCANP00000006850PDZ domain-containing protein. (282 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (484 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
LOC105509062Uncharacterized protein. (647 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CDC37Cell division cycle 37. (378 aa)
FASFas cell surface death receptor. (331 aa)
LOC105515285HATPase_c domain-containing protein. (711 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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