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TXNDC11 TXNDC11 ATM ATM LOC105503496 LOC105503496 MDM4 MDM4 RICTOR RICTOR PHF20 PHF20 CCNA1 CCNA1 ENSCANP00000019642 ENSCANP00000019642 LOC105510915 LOC105510915 AKT2 AKT2 AKT1 AKT1 LOC105523183 LOC105523183 UBA52 UBA52 CDK2 CDK2 CDK3 CDK3 RPS27A RPS27A ENSCANP00000000485 ENSCANP00000000485 USP2 USP2 CDK1 CDK1 MAPKAP1 MAPKAP1 CCNG1 CCNG1 ENSCANP00000037307 ENSCANP00000037307 ENSCANP00000036167 ENSCANP00000036167 PPP2R1B PPP2R1B ENSCANP00000032612 ENSCANP00000032612 LOC105521899 LOC105521899 RNF34 RNF34 CHEK2 CHEK2 CCNA2 CCNA2 PPP2R1A PPP2R1A PPP2CA PPP2CA TP53 TP53 DAXX DAXX AKT3 AKT3 PPP2CB PPP2CB SGK1 SGK1 ENSCANP00000024123 ENSCANP00000024123 PDPK1 PDPK1 PPP2R5C PPP2R5C MDM2 MDM2 MLST8 MLST8 ENSCANP00000022288 ENSCANP00000022288 MTOR MTOR LOC105517114 LOC105517114 RFFL RFFL USP7 USP7 PRDM1 PRDM1 ENSCANP00000004759 ENSCANP00000004759 ENSCANP00000007912 ENSCANP00000007912 LOC105510963 LOC105510963
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TXNDC11Thioredoxin domain containing 11. (900 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
MDM4MDM4 regulator of p53. (340 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1698 aa)
PHF20PHD finger protein 20. (1014 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
LOC105510915Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (301 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (576 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
ENSCANP00000037307Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa)
ENSCANP00000036167Uncharacterized protein. (105 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
ENSCANP00000032612SWIB domain-containing protein. (72 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
RNF34Ring finger protein 34. (468 aa)
CHEK2Checkpoint kinase 2. (589 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (594 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
DAXXDeath domain associated protein. (751 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
ENSCANP00000024123Uncharacterized protein. (86 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
MDM2MDM2 proto-oncogene. (513 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (355 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1102 aa)
PRDM1PR/SET domain 1. (825 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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