STRINGSTRING
PSMD14 PSMD14 PSMB5 PSMB5 ANAPC7 ANAPC7 ANAPC4 ANAPC4 ENSCANP00000036083 ENSCANP00000036083 PSMB9 PSMB9 MCM4 MCM4 PRIM2 PRIM2 ENSCANP00000012316 ENSCANP00000012316 DNA2 DNA2 LOC105523183 LOC105523183 ENSCANP00000011827 ENSCANP00000011827 PSME2 PSME2 UBA52 UBA52 PSMA1 PSMA1 ATAD5 ATAD5 CDK3 CDK3 ENSCANP00000010775 ENSCANP00000010775 UBE2D1 UBE2D1 ENSCANP00000010057 ENSCANP00000010057 CUL1 CUL1 PSMD5 PSMD5 CDT1 CDT1 RFC5 RFC5 ENSCANP00000008806 ENSCANP00000008806 PSMB2 PSMB2 RFC1 RFC1 ENSCANP00000007912 ENSCANP00000007912 PSMA6 PSMA6 RPA3 RPA3 POLE3 POLE3 RFC2 RFC2 RCBTB1 RCBTB1 ENSCANP00000007099 ENSCANP00000007099 ORC1 ORC1 UBE2C UBE2C LOC105508356 LOC105508356 ENSCANP00000006295 ENSCANP00000006295 ENSCANP00000005901 ENSCANP00000005901 ANAPC16 ANAPC16 PSMB11 PSMB11 PSMD6 PSMD6 LOC105509448 LOC105509448 ENSCANP00000004759 ENSCANP00000004759 ORC6 ORC6 RBX1 RBX1 FEN1 FEN1 LOC105516879 LOC105516879 ORC5 ORC5 MCM3 MCM3 CCNE1 CCNE1 LOC105517114 LOC105517114 MCM7 MCM7 RCBTB2 RCBTB2 ANAPC10 ANAPC10 CDC26 CDC26 MCM8 MCM8 LOC105521899 LOC105521899 ENSCANP00000000485 ENSCANP00000000485 ENSCANP00000000468 ENSCANP00000000468 PSME3 PSME3 RPS27A RPS27A PSMB7 PSMB7 POLD2 POLD2 LOC105500584 LOC105500584 LOC105520745 LOC105520745 PSMA2 PSMA2 GINS1 GINS1 RFC4 RFC4 LOC105521476 LOC105521476 SKP1 SKP1 PSMB1 PSMB1 ENSCANP00000028178 ENSCANP00000028178 PSMF1 PSMF1 LOC105520594 LOC105520594 ENSCANP00000027240 ENSCANP00000027240 ENSCANP00000013611 ENSCANP00000013611 RFC3 RFC3 PSMA5 PSMA5 PSMA4 PSMA4 GMNN GMNN TM7SF3 TM7SF3 PSMB8 PSMB8 ENSCANP00000026188 ENSCANP00000026188 ENSCANP00000026071 ENSCANP00000026071 ORC4 ORC4 ENSCANP00000025746 ENSCANP00000025746 PSMD11 PSMD11 PSMD8 PSMD8 GINS2 GINS2 ENSCANP00000023943 ENSCANP00000023943 MCM6 MCM6 PRIM1 PRIM1 ENSCANP00000022288 ENSCANP00000022288 MCM9 MCM9 PSMD1 PSMD1 TM4SF19 TM4SF19 PSMD10 PSMD10 ENSCANP00000020516 ENSCANP00000020516 ORC3 ORC3 UBE2E1 UBE2E1 ENSCANP00000019642 ENSCANP00000019642 CCNA1 CCNA1 PSMC4 PSMC4 POLD1 POLD1 FZR1 FZR1 PSMC3 PSMC3 ENSCANP00000018891 ENSCANP00000018891 GINS3 GINS3 ENSCANP00000018273 ENSCANP00000018273 PSMD2 PSMD2 ENSCANP00000017387 ENSCANP00000017387 CCNE2 CCNE2 CDC45 CDC45 ENSCANP00000016508 ENSCANP00000016508 LOC105503496 LOC105503496 PSME1 PSME1 PSMB10 PSMB10 CDK2 CDK2 CDC16 CDC16 PCNA PCNA PSMA7 PSMA7 PSMA8 PSMA8 RPA1 RPA1 CDC23 CDC23 LOC105518935 LOC105518935 LIG1 LIG1 PSMC6 PSMC6 ENSCANP00000014002 ENSCANP00000014002 PSMB6 PSMB6 ANAPC5 ANAPC5 PSMD12 PSMD12 CCNA2 CCNA2 PSME4 PSME4 POLA1 POLA1 POLE2 POLE2 MEIOB MEIOB POLD3 POLD3 PSMB4 PSMB4 SKP2 SKP2 PSMD4 PSMD4 ENSCANP00000032089 ENSCANP00000032089 ENSCANP00000032300 ENSCANP00000032300 PSMA3 PSMA3 PSMD7 PSMD7 ANAPC11 ANAPC11 ENSCANP00000032549 ENSCANP00000032549 PSMC2 PSMC2 ENSCANP00000033944 ENSCANP00000033944 ORC2 ORC2 ANAPC1 ANAPC1 ENSCANP00000035446 ENSCANP00000035446 PSMD3 PSMD3 POLD4 POLD4 POLE4 POLE4 MCM2 MCM2 POLA2 POLA2 UBE2S UBE2S PSMD9 PSMD9 ANAPC15 ANAPC15 ANAPC2 ANAPC2 GINS4 GINS4 CDC6 CDC6 POLE POLE PSMD13 PSMD13 PSMC5 PSMC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMB5Proteasome subunit beta. (263 aa)
ANAPC7Anaphase promoting complex subunit 7. (599 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (817 aa)
ENSCANP00000036083Uncharacterized protein. (111 aa)
PSMB9Proteasome subunit beta 9. (177 aa)
MCM4DNA helicase; Belongs to the MCM family. (866 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
ENSCANP00000012316UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa)
DNA2DNA replication helicase/nuclease 2. (1042 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
ENSCANP00000011827Uncharacterized protein. (106 aa)
PSME2Proteasome activator subunit 2. (255 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
ATAD5ATPase family AAA domain containing 5. (1726 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (301 aa)
ENSCANP00000010775ATPase_AAA_core domain-containing protein. (385 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
ENSCANP00000010057AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
CDT1Chromatin licensing and DNA replication factor 1. (470 aa)
RFC5Replication factor C subunit 5. (343 aa)
ENSCANP00000008806Uncharacterized protein. (357 aa)
PSMB2Proteasome subunit beta. (201 aa)
RFC1Replication factor C subunit 1. (1148 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
RPA3Replication protein A3. (121 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
RFC2Replication factor C subunit 2. (341 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ENSCANP00000007099Uncharacterized protein. (213 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa)
UBE2CUncharacterized protein. (161 aa)
LOC105508356PCI domain-containing protein. (411 aa)
ENSCANP00000006295ANK_REP_REGION domain-containing protein. (151 aa)
ENSCANP00000005901UBIQUITIN_CONJUGAT_2 domain-containing protein. (202 aa)
ANAPC16Anaphase promoting complex subunit 16. (110 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
LOC105509448Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
RBX1Ring-box 1. (108 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC105516879Proteasome endopeptidase complex. (214 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
MCM3DNA helicase; Belongs to the MCM family. (831 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (409 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (561 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
CDC26Cell division cycle 26. (85 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (762 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
ENSCANP00000000468ATPase_AAA_core domain-containing protein. (421 aa)
PSME3Proteasome activator subunit 3. (170 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSMB7Proteasome subunit beta. (277 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
LOC105500584Uncharacterized protein. (180 aa)
LOC105520745AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
GINS1GINS complex subunit 1. (196 aa)
RFC4Replication factor C subunit 4. (363 aa)
LOC10552147626S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (834 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSCANP00000028178Uncharacterized protein. (87 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
LOC105520594AAA domain-containing protein; Belongs to the AAA ATPase family. (442 aa)
ENSCANP00000027240Uncharacterized protein. (84 aa)
ENSCANP00000013611AAA domain-containing protein. (371 aa)
RFC3Replication factor C subunit 3. (356 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
PSMB8Proteasome subunit beta. (284 aa)
ENSCANP00000026188AAA domain-containing protein; Belongs to the AAA ATPase family. (430 aa)
ENSCANP00000026071RFC1 domain-containing protein. (136 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ENSCANP00000025746Uncharacterized protein; Belongs to the SKP1 family. (167 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (410 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
ENSCANP00000023943Proteasome subunit beta. (204 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
TM4SF19Uncharacterized protein. (209 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSCANP00000020516CSN8_PSD8_EIF3K domain-containing protein. (254 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1012 aa)
FZR1Fizzy and cell division cycle 20 related 1. (498 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
ENSCANP00000018891Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
GINS3GINS complex subunit 3. (255 aa)
ENSCANP00000018273UBIQUITIN_CONJUGAT_2 domain-containing protein. (173 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (747 aa)
ENSCANP00000017387Proteasome subunit beta. (181 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CDC45Cell division cycle 45. (598 aa)
ENSCANP00000016508JAB_MPN domain-containing protein. (167 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
PSME1Proteasome activator subunit 1. (247 aa)
PSMB10Proteasome subunit beta. (273 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
CDC16Cell division cycle 16. (613 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PSMA7Proteasome endopeptidase complex. (178 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (574 aa)
CDC23Cell division cycle 23. (597 aa)
LOC105518935AAA domain-containing protein; Belongs to the AAA ATPase family. (426 aa)
LIG1DNA ligase. (919 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
ENSCANP00000014002Sld5 domain-containing protein. (160 aa)
PSMB6Proteasome subunit beta. (245 aa)
ANAPC5Anaphase promoting complex subunit 5. (689 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PSME4Proteasome activator subunit 4. (1844 aa)
POLA1DNA polymerase. (1474 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
MEIOBMeiosis specific with OB-fold. (392 aa)
POLD3Uncharacterized protein. (454 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
ENSCANP00000032089Uncharacterized protein. (120 aa)
ENSCANP00000032300DOC domain-containing protein. (141 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
ANAPC11Anaphase promoting complex subunit 11. (180 aa)
ENSCANP00000032549AAA_lid_3 domain-containing protein. (354 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
ENSCANP00000033944Uncharacterized protein; Belongs to the SKP1 family. (131 aa)
ORC2Origin recognition complex subunit 2. (561 aa)
ANAPC1Anaphase promoting complex subunit 1. (1902 aa)
ENSCANP00000035446Uncharacterized protein. (125 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
POLD4Uncharacterized protein. (107 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
PSMD9PDZ domain-containing protein. (223 aa)
ANAPC15Anaphase promoting complex subunit 15. (190 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2267 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (399 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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