STRINGSTRING
LOC105526734 LOC105526734 POT1 POT1 LOC105513874 LOC105513874 LOC105513882 LOC105513882 LOC105526741-3 LOC105526741-3 POLR2A POLR2A LOC105526737 LOC105526737 FEN1 FEN1 LOC105526740 LOC105526740 H2BC1 H2BC1 H2BC3 H2BC3 LOC105509399 LOC105509399 LOC105526741-4 LOC105526741-4 LOC105526748 LOC105526748 LOC105519951 LOC105519951 LOC105506127 LOC105506127 LOC105513873 LOC105513873 RBBP4 RBBP4 H2AZ2 H2AZ2 LOC105513883 LOC105513883 LOC105513905 LOC105513905 LOC105506722 LOC105506722 NPM1 NPM1 H2BC14 H2BC14 LOC105513908 LOC105513908 LOC105509448 LOC105509448 RTEL1 RTEL1 LOC105526752 LOC105526752 LOC105526753 LOC105526753 LOC105526757 LOC105526757 ITGB3BP ITGB3BP ENSCANP00000006424 ENSCANP00000006424 CTC1 CTC1 TERF1 TERF1 POLR2H POLR2H RCBTB1 RCBTB1 RFC2 RFC2 RUVBL2 RUVBL2 RPA3 RPA3 POLR2E POLR2E RFC1 RFC1 DKC1 DKC1 RFC5 RFC5 CHTF18 CHTF18 LOC105501639 LOC105501639 PIF1 PIF1 CDK3 CDK3 STN1 STN1 TRUB1 TRUB1 CENPK CENPK DNA2 DNA2 DSCC1 DSCC1 MIS18A MIS18A PRIM2 PRIM2 RFC3 RFC3 ANKRD66 ANKRD66 CENPC CENPC LIG1 LIG1 LOC105515702 LOC105515702 LOC105501368 LOC105501368 ENSCANP00000014925 ENSCANP00000014925 RPA1 RPA1 PCNA PCNA CDK2 CDK2 NHP2 NHP2 ACD ACD ENSCANP00000016884 ENSCANP00000016884 ANKRD44 ANKRD44 POLR2I POLR2I CENPM CENPM CENPU CENPU ATRX ATRX LOC105512667 LOC105512667 PPP6R3 PPP6R3 LOC105519471 LOC105519471 POLD1 POLD1 CCNA1 CCNA1 LOC105512501 LOC105512501 TERT TERT ENSCANP00000020858 ENSCANP00000020858 CENPA CENPA KNL1 KNL1 LOC105508421 LOC105508421 PRIM1 PRIM1 LOC105517192 LOC105517192 BLM BLM POLR2C POLR2C CENPL CENPL TERF2 TERF2 MIS18BP1 MIS18BP1 PPP6R2 PPP6R2 CENPW CENPW TERF2IP TERF2IP EXD2 EXD2 ENSCANP00000026071 ENSCANP00000026071 CENPX CENPX LOC105517182 LOC105517182 CHTF8 CHTF8 WRN WRN OIP5 OIP5 LOC105520302 LOC105520302 DAXX DAXX RFC4 RFC4 ENSCANP00000029611 ENSCANP00000029611 LOC105524989 LOC105524989 H2BU1 H2BU1 LOC105524985 LOC105524985 H2BC21 H2BC21 H2AC20 H2AC20 CCNA2 CCNA2 H3F3B H3F3B POLA1 POLA1 MEIOB MEIOB POLD3 POLD3 WRAP53 WRAP53 GAR1 GAR1 SHQ1 SHQ1 TEN1 TEN1 RBPMS2 RBPMS2 ENSCANP00000032089 ENSCANP00000032089 LOC105505861 LOC105505861 HJURP HJURP PPP6C PPP6C H3F3A H3F3A ENSCANP00000033684 ENSCANP00000033684 CENPH CENPH CENPN CENPN CENPI CENPI POLD4 POLD4 CENPQ CENPQ POLR2D POLR2D ENSCANP00000039811 ENSCANP00000039811 POLA2 POLA2 RECQL4 RECQL4 ANKRD28 ANKRD28 POLR2G POLR2G RUVBL1 RUVBL1 POLR2L POLR2L ENSCANP00000038681 ENSCANP00000038681 ENSCANP00000037817 ENSCANP00000037817 POLR2F POLR2F POLR2B POLR2B ENSCANP00000036099 ENSCANP00000036099 LOC105521072 LOC105521072 POLR2K POLR2K RSF1 RSF1 SMARCA5 SMARCA5 TINF2 TINF2 H2BW2 H2BW2 ENSCANP00000034865 ENSCANP00000034865 CENPO CENPO LOC105517382 LOC105517382 ENSCANP00000000012 ENSCANP00000000012 POLD2 POLD2 CENPP CENPP LOC105526741 LOC105526741 ENSCANP00000000858 ENSCANP00000000858 H2BC15 H2BC15 NOP10 NOP10 RBBP7 RBBP7 ENSCANP00000001382 ENSCANP00000001382 RCBTB2 RCBTB2 H2AC7 H2AC7 H2AC6 H2AC6 LOC105520452 LOC105520452 LOC105526741-2 LOC105526741-2 CENPT CENPT H2BC5 H2BC5 H2AJ H2AJ LOC105526758 LOC105526758 LOC105526736 LOC105526736 ENSCANP00000002473 ENSCANP00000002473 LOC105510607 LOC105510607 H2AX H2AX LOC105507268 LOC105507268 SMARCA1 SMARCA1 ENSCANP00000002755 ENSCANP00000002755 ENSCANP00000002791 ENSCANP00000002791
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105526734Histone H2A; Belongs to the histone H2A family. (130 aa)
POT1Protection of telomeres 1. (634 aa)
LOC105513874Histone H4. (103 aa)
LOC105513882Histone H4. (103 aa)
LOC105526741-3Histone H2B type 1. (126 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1986 aa)
LOC105526737Histone H4. (103 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC105526740Histone H4. (103 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105509399Histone H3; Belongs to the histone H3 family. (135 aa)
LOC105526741-4Histone H2B type 1. (126 aa)
LOC105526748Histone H4. (103 aa)
LOC105519951Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105506127Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105513873Histone H2B; Belongs to the histone H2B family. (126 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (102 aa)
LOC105513883Histone H4. (103 aa)
LOC105513905Histone H4. (103 aa)
LOC105506722Histone H3; Belongs to the histone H3 family. (136 aa)
NPM1Nucleophosmin 1. (293 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105513908Histone H2B type 1-J. (126 aa)
LOC105509448Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1335 aa)
LOC105526752Histone H4. (103 aa)
LOC105526753Histone H2A type 1. (130 aa)
LOC105526757Histone H4. (103 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (215 aa)
ENSCANP00000006424annotation not available (103 aa)
CTC1CST telomere replication complex component 1. (1212 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
POLR2HRNA polymerase II subunit H. (175 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RFC2Replication factor C subunit 2. (341 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (466 aa)
RPA3Replication protein A3. (121 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
RFC1Replication factor C subunit 1. (1148 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
RFC5Replication factor C subunit 5. (343 aa)
CHTF18Uncharacterized protein. (814 aa)
LOC105501639WD_REPEATS_REGION domain-containing protein. (398 aa)
PIF1ATP-dependent DNA helicase; Belongs to the helicase family. (587 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (301 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
TRUB1TruB pseudouridine synthase family member 1. (350 aa)
CENPKCentromere protein K. (269 aa)
DNA2DNA replication helicase/nuclease 2. (1042 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (393 aa)
MIS18AMIS18 kinetochore protein A. (232 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
RFC3Replication factor C subunit 3. (356 aa)
ANKRD66Ankyrin repeat domain 66. (250 aa)
CENPCCentromere protein C. (945 aa)
LIG1DNA ligase. (919 aa)
LOC105515702AAA domain-containing protein. (798 aa)
LOC105501368Uncharacterized protein. (449 aa)
ENSCANP00000014925Histone H2B; Belongs to the histone H2B family. (121 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (574 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (485 aa)
ENSCANP00000016884Uncharacterized protein. (77 aa)
ANKRD44Ankyrin repeat domain 44. (553 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa)
CENPMCentromere protein M. (180 aa)
CENPUCentromere protein U. (417 aa)
ATRXATRX chromatin remodeler. (2490 aa)
LOC105512667Histone H2A; Belongs to the histone H2A family. (130 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
LOC105519471Uncharacterized protein. (291 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1012 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
LOC105512501WD_REPEATS_REGION domain-containing protein. (396 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1059 aa)
ENSCANP00000020858Uncharacterized protein. (185 aa)
CENPACentromere protein A. (113 aa)
KNL1Kinetochore scaffold 1. (2204 aa)
LOC105508421TINF2_N domain-containing protein. (454 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
LOC105517192Uncharacterized protein. (280 aa)
BLMBLM RecQ like helicase. (1146 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
CENPLCentromere protein L. (390 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (471 aa)
MIS18BP1MIS18 binding protein 1. (1131 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (939 aa)
CENPWCentromere protein W. (103 aa)
TERF2IPTERF2 interacting protein. (235 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
ENSCANP00000026071RFC1 domain-containing protein. (136 aa)
CENPXCentromere protein X. (133 aa)
LOC105517182Uncharacterized protein. (291 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
WRNWRN RecQ like helicase. (1431 aa)
OIP5Mis18 domain-containing protein. (229 aa)
LOC105520302Histone H3; Belongs to the histone H3 family. (136 aa)
DAXXDeath domain associated protein. (751 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSCANP00000029611Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (151 aa)
LOC105524989Histone H3; Belongs to the histone H3 family. (136 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105524985Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
H3F3BHistone domain-containing protein. (191 aa)
POLA1DNA polymerase. (1474 aa)
MEIOBMeiosis specific with OB-fold. (392 aa)
POLD3Uncharacterized protein. (454 aa)
WRAP53WD repeat containing antisense to TP53. (518 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (217 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (572 aa)
TEN1Uncharacterized protein. (123 aa)
RBPMS2Uncharacterized protein. (94 aa)
ENSCANP00000032089Uncharacterized protein. (120 aa)
LOC105505861Histone H2A; Belongs to the histone H2A family. (116 aa)
HJURPHolliday junction recognition protein. (721 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
ENSCANP00000033684Histone H2A; Belongs to the histone H2A family. (107 aa)
CENPHCentromere protein H. (221 aa)
CENPNCentromere protein N. (339 aa)
CENPICentromere protein I. (754 aa)
POLD4Uncharacterized protein. (107 aa)
CENPQCentromere protein Q. (268 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
ENSCANP00000039811Uncharacterized protein. (263 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
RECQL4RecQ like helicase 4. (1154 aa)
ANKRD28Ankyrin repeat domain 28. (1086 aa)
POLR2GRNA polymerase II subunit G. (231 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
ENSCANP00000038681Uncharacterized protein. (56 aa)
ENSCANP00000037817Uncharacterized protein. (157 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
ENSCANP00000036099Mis18 domain-containing protein. (220 aa)
LOC105521072Uncharacterized protein. (280 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
RSF1Remodeling and spacing factor 1. (1422 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
ENSCANP00000034865Histone H2A; Belongs to the histone H2A family. (122 aa)
CENPOCentromere protein O. (298 aa)
LOC105517382Uncharacterized protein. (191 aa)
ENSCANP00000000012Nucleoplasmin domain-containing protein. (237 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
CENPPUncharacterized protein. (115 aa)
LOC105526741Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCANP00000000858Histone H2B; Belongs to the histone H2B family. (136 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
NOP10Uncharacterized protein. (64 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (466 aa)
ENSCANP00000001382Histone H3; Belongs to the histone H3 family. (136 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (561 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC105520452Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC105526741-2Histone H2B type 1. (126 aa)
CENPTCentromere protein T. (560 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC105526758Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105526736Histone H4. (103 aa)
ENSCANP00000002473Histone H2B; Belongs to the histone H2B family. (134 aa)
LOC105510607Histone H3; Belongs to the histone H3 family. (136 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC105507268Histone H3; Belongs to the histone H3 family. (136 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa)
ENSCANP00000002755WD_REPEATS_REGION domain-containing protein. (343 aa)
ENSCANP00000002791Histone H2B; Belongs to the histone H2B family. (129 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (22%) [HD]