STRINGSTRING
SCARB2 SCARB2 GRB2 GRB2 TOR1A TOR1A TOR1B TOR1B TACR1 TACR1 CLTB CLTB VAMP8 VAMP8 CBL CBL AREG AREG KIAA0319L KIAA0319L KIAA0319 KIAA0319 ENSCANP00000037990 ENSCANP00000037990 AP2A1 AP2A1 ZFYVE1 ZFYVE1 AVPR2 AVPR2 COPS5 COPS5 BTC BTC VAMP3 VAMP3 CD4 CD4 NECAP1 NECAP1 EPGN EPGN LDLRAP1 LDLRAP1 IGF2R IGF2R AGTR1 AGTR1 EPN1 EPN1 IL7R IL7R EPS15 EPS15 PICALM PICALM COPS8 COPS8 UBQLN4 UBQLN4 VAMP4 VAMP4 CLTA CLTA MCTP2 MCTP2 LOC105525710 LOC105525710 FCHO2 FCHO2 HGS HGS LRP2 LRP2 CD3G CD3G AP2A2 AP2A2 ENSCANP00000033455 ENSCANP00000033455 WNT5A WNT5A PPP1R42 PPP1R42 NETO2 NETO2 ENSCANP00000032593 ENSCANP00000032593 STON2 STON2 LMBRD2 LMBRD2 VAMP5 VAMP5 ENSCANP00000029966 ENSCANP00000029966 CD3D CD3D CLTC CLTC LOC105501272 LOC105501272 DVL2 DVL2 SH3GL1 SH3GL1 AP2B1 AP2B1 COPS4 COPS4 COPS6 COPS6 SYT9 SYT9 SYT11 SYT11 STON1 STON1 SH3GL2 SH3GL2 SYT8 SYT8 MCTP1 MCTP1 NECAP2 NECAP2 GRK3 GRK3 UBQLNL UBQLNL AGFG1 AGFG1 EPN3 EPN3 ENSCANP00000022288 ENSCANP00000022288 ITSN1 ITSN1 AP2S1 AP2S1 COPS7A COPS7A SYT4 SYT4 EREG EREG REPS1 REPS1 FCHO1 FCHO1 CFTR CFTR ENSCANP00000019642 ENSCANP00000019642 VAMP2 VAMP2 EGF EGF ARRB1 ARRB1 ARR3 ARR3 EGFR EGFR STAM STAM TFRC TFRC EPN2 EPN2 SNAP91 SNAP91 LOC105503496 LOC105503496 UBQLN1 UBQLN1 CLTCL1 CLTCL1 AGFG2 AGFG2 STAM2 STAM2 COPS3 COPS3 NEDD8 NEDD8 DAB2 DAB2 LOC105524041 LOC105524041 SH3GL3 SH3GL3 LOC105523183 LOC105523183 COPS2 COPS2 UBA52 UBA52 UBL7 UBL7 GRK2 GRK2 SYT1 SYT1 AP2M1 AP2M1 VAMP7 VAMP7 TF TF SGIP1 SGIP1 FZD4 FZD4 EPS15L1 EPS15L1 LDLR LDLR M6PR M6PR AAK1 AAK1 ENSCANP00000007912 ENSCANP00000007912 BMP2K BMP2K ITSN2 ITSN2 TGFA TGFA NETO1 NETO1 PGBD4 PGBD4 HBEGF HBEGF SH3KBP1 SH3KBP1 GPS1 GPS1 SYT2 SYT2 ENTHD1 ENTHD1 ENSCANP00000004759 ENSCANP00000004759 CLHC1 CLHC1 SLC2A8 SLC2A8 ADRB2 ADRB2 CHRM2 CHRM2 CLPB CLPB ENSCANP00000002260 ENSCANP00000002260 LOC105517114 LOC105517114 UBQLN2 UBQLN2 ARRB2 ARRB2 ZFYVE19 ZFYVE19 REPS2 REPS2 LOC105521899 LOC105521899 ENSCANP00000000485 ENSCANP00000000485 RPS27A RPS27A COPS7B COPS7B APOB APOB TGOLN2 TGOLN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
GRB2Uncharacterized protein. (156 aa)
TOR1ATorsin family 1 member A. (309 aa)
TOR1BTorsin family 1 member B. (269 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (166 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
CBLCbl proto-oncogene. (888 aa)
AREGAmphiregulin. (275 aa)
KIAA0319LKIAA0319 like. (1049 aa)
KIAA0319KIAA0319. (1072 aa)
ENSCANP00000037990Uncharacterized protein. (52 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (953 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (716 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
COPS5Uncharacterized protein. (78 aa)
BTCBetacellulin. (178 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
CD4CD4 molecule. (458 aa)
NECAP1NECAP endocytosis associated 1. (275 aa)
EPGNEpithelial mitogen. (154 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
IGF2RInsulin like growth factor 2 receptor. (2483 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
EPN1Epsin 1. (662 aa)
IL7RInterleukin 7 receptor. (458 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (886 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (672 aa)
COPS8COP9 signalosome subunit 8. (209 aa)
UBQLN4Ubiquitin-like domain-containing protein. (572 aa)
VAMP4Vesicle associated membrane protein 4. (141 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (237 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (877 aa)
LOC105525710Uncharacterized protein. (3238 aa)
FCHO2FCH domain only 2. (809 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
LRP2LDL receptor related protein 2. (4655 aa)
CD3GCD3g molecule. (181 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (950 aa)
ENSCANP00000033455BAR domain-containing protein. (299 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PPP1R42Protein phosphatase 1 regulatory subunit 42. (357 aa)
NETO2Neuropilin and tolloid like 2. (506 aa)
ENSCANP00000032593EH domain-containing protein. (109 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (920 aa)
LMBRD2LMBR1 domain containing 2. (695 aa)
VAMP5Vesicle associated membrane protein 5. (115 aa)
ENSCANP00000029966B2-adapt-app_C domain-containing protein. (214 aa)
CD3DCD3d molecule. (171 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
LOC105501272Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (222 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (365 aa)
AP2B1AP complex subunit beta. (951 aa)
COPS4COP9 signalosome subunit 4. (437 aa)
COPS6COP9 signalosome subunit 6. (430 aa)
SYT9Synaptotagmin 9. (491 aa)
SYT11Synaptotagmin 11. (431 aa)
STON1Stonin-1; May be involved in the endocytic machinery. (735 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
SYT8Synaptotagmin 8. (387 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (942 aa)
NECAP2NECAP endocytosis associated 2. (238 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
UBQLNLUbiquilin like. (457 aa)
AGFG1ArfGAP with FG repeats 1. (528 aa)
EPN3Epsin 3. (558 aa)
ENSCANP00000022288Ubiquitin-like domain-containing protein. (79 aa)
ITSN1Intersectin 1. (1713 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
COPS7ACOP9 signalosome subunit 7A. (275 aa)
SYT4Synaptotagmin 4. (425 aa)
EREGEpiregulin. (169 aa)
REPS1RALBP1 associated Eps domain containing 1. (796 aa)
FCHO1FCH domain only 1. (942 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
ENSCANP00000019642Ribosomal_S27 domain-containing protein. (93 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
ARRB1Arrestin beta 1. (418 aa)
ARR3Arrestin 3. (389 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
STAMSignal transducing adaptor molecule. (540 aa)
TFRCTransferrin receptor. (710 aa)
EPN2Epsin 2. (641 aa)
SNAP91Synaptosome associated protein 91. (907 aa)
LOC105503496Ubiquitin-like domain-containing protein. (147 aa)
UBQLN1Ubiquilin 1. (589 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1626 aa)
AGFG2ArfGAP with FG repeats 2. (466 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
COPS3COP9 signalosome subunit 3. (361 aa)
NEDD8NEDD8 ubiquitin like modifier. (82 aa)
DAB2DAB adaptor protein 2. (770 aa)
LOC105524041Uncharacterized protein. (588 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (354 aa)
LOC105523183Ubiquitin-like domain-containing protein. (77 aa)
COPS2COP9 signalosome subunit 2. (450 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
UBL7Ubiquitin like 7. (380 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (693 aa)
SYT1Synaptotagmin 1. (422 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (828 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (857 aa)
LDLRLow density lipoprotein receptor. (777 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
AAK1AP2 associated kinase 1. (959 aa)
ENSCANP00000007912Ubiquitin-like domain-containing protein. (121 aa)
BMP2KBMP2 inducible kinase. (1101 aa)
ITSN2Intersectin 2. (1703 aa)
TGFATransforming growth factor alpha. (166 aa)
NETO1Neuropilin and tolloid like 1. (533 aa)
PGBD4PiggyBac transposable element derived 4. (585 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (663 aa)
GPS1G protein pathway suppressor 1. (536 aa)
SYT2Synaptotagmin 2. (419 aa)
ENTHD1ENTH domain containing 1. (608 aa)
ENSCANP00000004759Ubiquitin-like domain-containing protein. (147 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (464 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (417 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (461 aa)
ENSCANP00000002260Uncharacterized protein. (62 aa)
LOC105517114Ubiquitin-like domain-containing protein. (156 aa)
UBQLN2Ubiquilin 2. (624 aa)
ARRB2Arrestin beta 2. (492 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (462 aa)
REPS2RALBP1 associated Eps domain containing 2. (590 aa)
LOC105521899Ubiquitin-like domain-containing protein. (146 aa)
ENSCANP00000000485Ubiquitin-like domain-containing protein. (72 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
COPS7BPCI domain-containing protein. (163 aa)
APOBApolipoprotein B. (4555 aa)
TGOLN2Trans-golgi network protein 2. (448 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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