22 items (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	ENSCANP00000000485	Ubiquitin-like domain-containing protein. (72 aa)
	LOC105521899	Ubiquitin-like domain-containing protein. (146 aa)
	ENSCANP00000002130	Uncharacterized protein. (106 aa)
	LOC105517114	Ubiquitin-like domain-containing protein. (156 aa)
	USP30	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (501 aa)
	ENSCANP00000004759	Ubiquitin-like domain-containing protein. (147 aa)
	PEX5	Peroxisomal biogenesis factor 5. (590 aa)
	ENSCANP00000007912	Ubiquitin-like domain-containing protein. (121 aa)
	PEX5L	Peroxisomal biogenesis factor 5 like. (626 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	LOC105523183	Ubiquitin-like domain-containing protein. (77 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	LOC105503496	Ubiquitin-like domain-containing protein. (147 aa)
	ILRUN	Inflammation and lipid regulator with UBA-like and NBR1-like domains. (298 aa)
	ENSCANP00000019642	Ribosomal_S27 domain-containing protein. (93 aa)
	ENSCANP00000022288	Ubiquitin-like domain-containing protein. (79 aa)
	EPAS1	Endothelial PAS domain protein 1. (869 aa)
	ENSCANP00000025568	Uncharacterized protein. (135 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	NBR1	NBR1 autophagy cargo receptor. (981 aa)
	MAP1LC3B	Uncharacterized protein. (128 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ENSCANP00000002130	ENSCANP00000015871	ENSCANP00000002130	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.428
ATM	ENSCANP00000019642	ENSCANP00000015871	ENSCANP00000019642	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ribosomal_S27 domain-containing protein.	0.500
ATM	ENSCANP00000025568	ENSCANP00000015871	ENSCANP00000025568	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.428
ATM	LOC105503496	ENSCANP00000015871	ENSCANP00000016322	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.500
ATM	LOC105517114	ENSCANP00000015871	ENSCANP00000002234	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.500
ATM	LOC105523183	ENSCANP00000015871	ENSCANP00000011982	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.694
ATM	MAP1LC3B	ENSCANP00000015871	ENSCANP00000036656	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.428
ATM	NBR1	ENSCANP00000015871	ENSCANP00000035497	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	NBR1 autophagy cargo receptor.	0.940
ATM	PEX5	ENSCANP00000015871	ENSCANP00000007378	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Peroxisomal biogenesis factor 5.	0.745
ATM	PEX5L	ENSCANP00000015871	ENSCANP00000009987	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Peroxisomal biogenesis factor 5 like.	0.707
ATM	RPS27A	ENSCANP00000015871	ENSCANP00000000407	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.500
ATM	SQSTM1	ENSCANP00000015871	ENSCANP00000032665	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sequestosome 1.	0.827
ENSCANP00000000485	ENSCANP00000019642	ENSCANP00000000485	ENSCANP00000019642	Ubiquitin-like domain-containing protein.	Ribosomal_S27 domain-containing protein.	0.891
ENSCANP00000000485	LOC105503496	ENSCANP00000000485	ENSCANP00000016322	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.892
ENSCANP00000000485	LOC105517114	ENSCANP00000000485	ENSCANP00000002234	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.892
ENSCANP00000000485	LOC105523183	ENSCANP00000000485	ENSCANP00000011982	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.910
ENSCANP00000000485	NBR1	ENSCANP00000000485	ENSCANP00000035497	Ubiquitin-like domain-containing protein.	NBR1 autophagy cargo receptor.	0.921
ENSCANP00000000485	RPS27A	ENSCANP00000000485	ENSCANP00000000407	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.892
ENSCANP00000000485	SQSTM1	ENSCANP00000000485	ENSCANP00000032665	Ubiquitin-like domain-containing protein.	Sequestosome 1.	0.521
ENSCANP00000000485	USP30	ENSCANP00000000485	ENSCANP00000002890	Ubiquitin-like domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.808