(67 nodes) Alanine, aspartate and glutamate metabolism network (Colobus angolensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALDH5A1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa)
	ENSCANP00000020094	Aspartate aminotransferase. (358 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa)
	ENSCANP00000018874	Uncharacterized protein. (195 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	GPR143	G protein-coupled receptor 143. (407 aa)
	IL4I1	Amine oxidase. (579 aa)
	GFPT2	Glutamine-fructose-6-phosphate transaminase 2. (593 aa)
	ASPA	Aspartoacylase. (313 aa)
	ENSCANP00000015695	Uncharacterized protein. (367 aa)
	ADSS2	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (514 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	GOT1L1	Glutamic-oxaloacetic transaminase 1 like 1. (421 aa)
	FOLH1	Folate hydrolase 1. (750 aa)
	ENSCANP00000011808	NifU domain-containing protein. (81 aa)
	ASNSD1	Glutamine amidotransferase type-2 domain-containing protein. (643 aa)
	TMEM109	Transmembrane protein 109. (243 aa)
	ENSCANP00000010799	CN hydrolase domain-containing protein. (272 aa)
	RIMKLB	Ribosomal modification protein rimK like family member B. (386 aa)
	ASS1	Argininosuccinate synthase 1. (391 aa)
	ENSCANP00000006489	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (267 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1507 aa)
	GLUL	Glutamine synthetase. (373 aa)
	NFU1	Nfu_N domain-containing protein. (185 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa)
	ENSCANP00000000620	ATP-grasp domain-containing protein. (386 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	TMEM116	Transmembrane protein 116. (245 aa)
	LOC105519911	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (549 aa)
	GFPT1	Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
	ENSCANP00000032753	RimK domain-containing protein. (344 aa)
	ENSCANP00000032715	Uncharacterized protein. (321 aa)
	DDO	D-aspartate oxidase. (369 aa)
	ENSCANP00000032385	AAA domain-containing protein; Belongs to the AAA ATPase family. (336 aa)
	AGXT	Serine--pyruvate aminotransferase. (392 aa)
	ENSCANP00000031967	Aminotran_1_2 domain-containing protein. (355 aa)
	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (523 aa)
	LOC105517438	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (261 aa)
	ENSCANP00000036168	Aminotran_1_2 domain-containing protein. (372 aa)
	ADSL	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (497 aa)
	GLS	Glutaminase. (669 aa)
	GLS2	Glutaminase 2. (603 aa)
	ADSS1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (499 aa)
	NAALADL1	N-acetylated alpha-linked acidic dipeptidase like 1. (778 aa)
	ENSCANP00000038566	Uncharacterized protein. (400 aa)
	RIMKLA	Ribosomal modification protein rimK like family member A. (386 aa)
	ASRGL1	Asparaginase and isoaspartyl peptidase 1. (308 aa)
	ACY3	Aminoacylase 3. (299 aa)
	NAALADL2	N-acetylated alpha-linked acidic dipeptidase like 2. (795 aa)
	LGSN	Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (507 aa)
	SLC22A16	Solute carrier family 22 member 16. (577 aa)
	GPKOW	G-patch domain and KOW motifs. (476 aa)
	GPT	Glutamic--pyruvic transaminase. (496 aa)
	GAD2	Glutamate decarboxylase 2. (564 aa)
	ASL	Argininosuccinate lyase. (464 aa)
	GOT2	Uncharacterized protein. (257 aa)
	LOC105519891	Aspartate aminotransferase. (424 aa)
	PPAT	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
	TASP1	Taspase 1. (297 aa)
	ENSCANP00000025188	ELFV_dehydrog domain-containing protein. (244 aa)
	ATAD1	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	ENSCANP00000023062	Nfu_N domain-containing protein. (218 aa)
	NAALAD2	N-acetylated alpha-linked acidic dipeptidase 2. (740 aa)
	NIT2	Nitrilase family member 2. (307 aa)
	ENSCANP00000020568	Uncharacterized protein. (455 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABAT	AGXT	ENSCANP00000000972	ENSCANP00000032289	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Serine--pyruvate aminotransferase.	0.803
ABAT	AGXT2	ENSCANP00000000972	ENSCANP00000015608	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.887
ABAT	ALDH4A1	ENSCANP00000000972	ENSCANP00000031329	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.649
ABAT	ALDH5A1	ENSCANP00000000972	ENSCANP00000020544	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.956
ABAT	ASL	ENSCANP00000000972	ENSCANP00000026305	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Argininosuccinate lyase.	0.598
ABAT	ASNS	ENSCANP00000000972	ENSCANP00000004827	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Asparagine synthetase [glutamine-hydrolyzing].	0.605
ABAT	ASNSD1	ENSCANP00000000972	ENSCANP00000011806	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamine amidotransferase type-2 domain-containing protein.	0.605
ABAT	DDO	ENSCANP00000000972	ENSCANP00000032533	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	D-aspartate oxidase.	0.563
ABAT	ENSCANP00000006489	ENSCANP00000000972	ENSCANP00000006489	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.669
ABAT	ENSCANP00000010799	ENSCANP00000000972	ENSCANP00000010799	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	CN hydrolase domain-containing protein.	0.545
ABAT	ENSCANP00000018874	ENSCANP00000000972	ENSCANP00000018874	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.465
ABAT	ENSCANP00000025188	ENSCANP00000000972	ENSCANP00000025188	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	ELFV_dehydrog domain-containing protein.	0.669
ABAT	GAD1	ENSCANP00000000972	ENSCANP00000018388	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase 1.	0.886
ABAT	GAD2	ENSCANP00000000972	ENSCANP00000026539	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase 2.	0.886
ABAT	GLUL	ENSCANP00000000972	ENSCANP00000005483	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamine synthetase.	0.465
ABAT	GOT1	ENSCANP00000000972	ENSCANP00000014823	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aspartate aminotransferase.	0.492
ABAT	GOT1L1	ENSCANP00000000972	ENSCANP00000013090	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamic-oxaloacetic transaminase 1 like 1.	0.498
ABAT	GPT	ENSCANP00000000972	ENSCANP00000026887	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamic--pyruvic transaminase.	0.441
ABAT	GPT2	ENSCANP00000000972	ENSCANP00000031175	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamic--pyruvic transaminase 2.	0.441
ABAT	LGSN	ENSCANP00000000972	ENSCANP00000030564	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family.	0.465