STRINGSTRING
MAP2K2 MAP2K2 LOC105503372 LOC105503372 PRKAG2 PRKAG2 REM1 REM1 RAG2 RAG2 SMAD3 SMAD3 RNF111 RNF111 GRB2 GRB2 CNTD2 CNTD2 CCNB2 CCNB2 MAPK14 MAPK14 ENSCANP00000039354 ENSCANP00000039354 ENSCANP00000038603 ENSCANP00000038603 HOMER1 HOMER1 IL6 IL6 CDKN2B CDKN2B PRKAG1 PRKAG1 RASGEF1A RASGEF1A ATG12 ATG12 PIK3CD PIK3CD GADD45A GADD45A IL10 IL10 IL7R IL7R SOS2 SOS2 BRAF BRAF PIK3R3 PIK3R3 MAP2K1 MAP2K1 INSR INSR IRS4 IRS4 INS INS CAT CAT MAPK13 MAPK13 GABARAPL2 GABARAPL2 SOS1 SOS1 FOXO1 FOXO1 PIK3R2 PIK3R2 SUCO SUCO TGFB3 TGFB3 LOC105511833 LOC105511833 TPTE2 TPTE2 S1PR4 S1PR4 SKP2 SKP2 CREBBP CREBBP CCNB3 CCNB3 ENSCANP00000030691 ENSCANP00000030691 PIK3CB PIK3CB TGFBR1 TGFBR1 G6PC2 G6PC2 LDLRAD4 LDLRAD4 SMAD4 SMAD4 LOC105515123 LOC105515123 SGK2 SGK2 GABARAPL1 GABARAPL1 FBXO32 FBXO32 AKT3 AKT3 CCND2 CCND2 SGK1 SGK1 SLC2A4 SLC2A4 STK4 STK4 PRKAA2 PRKAA2 STK11 STK11 MAPK1 MAPK1 BCL6B BCL6B GABARAP GABARAP CDKN1A CDKN1A FBXO25 FBXO25 CDKN1B CDKN1B CCNG2 CCNG2 PRMT3 PRMT3 ENSCANP00000024123 ENSCANP00000024123 CSDE1 CSDE1 PDPK1 PDPK1 PRMT1 PRMT1 PRKAB1 PRKAB1 STAT3 STAT3 GADD45G GADD45G ARAF ARAF AKT2 AKT2 MYO9B MYO9B FOXJ2 FOXJ2 MYO9A MYO9A PIK3R1 PIK3R1 TSSK4 TSSK4 PRKAG3 PRKAG3 TGFB2 TGFB2 RRAD RRAD LOC105527785 LOC105527785 MAPK8 MAPK8 CCND1 CCND1 IGF1 IGF1 ENSCANP00000019829 ENSCANP00000019829 EGF EGF MAPK10 MAPK10 AGAP2 AGAP2 RAF1 RAF1 PRMT8 PRMT8 EGFR EGFR G6PC G6PC ENSCANP00000017794 ENSCANP00000017794 SLC35E3 SLC35E3 PCK1 PCK1 RASL11B RASL11B PMEPA1 PMEPA1 PIK3CA PIK3CA NLK NLK CDK2 CDK2 ATM ATM MAPK3 MAPK3 GRM1 GRM1 LOC105504658 LOC105504658 CCNB1 CCNB1 AKT1 AKT1 EP300 EP300 HOMER2 HOMER2 PLK2 PLK2 GRAP GRAP MAPK12 MAPK12 LOC105515200 LOC105515200 IGF1R IGF1R RBL2 RBL2 GADD45B GADD45B GEM GEM ENSCANP00000012327 ENSCANP00000012327 PRKAA1 PRKAA1 TSSK3 TSSK3 CDK3 CDK3 IKBKB IKBKB MAPK9 MAPK9 PTEN PTEN PLK3 PLK3 BCL2L11 BCL2L11 ENSCANP00000009565 ENSCANP00000009565 PRKAB2 PRKAB2 FOXJ3 FOXJ3 SGK3 SGK3 TGFB1 TGFB1 PLK4 PLK4 PLK1 PLK1 PLK5 PLK5 FASLG FASLG SIRT1 SIRT1 G6PC3 G6PC3 SOD2 SOD2 BNIP3 BNIP3 FOXO3 FOXO3 TMEM232 TMEM232 HOMER3 HOMER3 ENSCANP00000006631 ENSCANP00000006631 KRAS KRAS IRS1 IRS1 RNF6 RNF6 CHUK CHUK HRAS HRAS FOXO4 FOXO4 TNFSF10 TNFSF10 RASGEF1B RASGEF1B TGFBR2 TGFBR2 TSSK6 TSSK6 USP7 USP7 CDKN2D CDKN2D SETD7 SETD7 SNAPIN SNAPIN ENSCANP00000002629 ENSCANP00000002629 PCK2 PCK2 BCL6 BCL6 ENSCANP00000002057 ENSCANP00000002057 S1PR1 S1PR1 ENSCANP00000001858 ENSCANP00000001858 MAPK11 MAPK11 ERAS ERAS RAG1 RAG1 TSSK2 TSSK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
LOC105503372Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (362 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (544 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
RAG2Recombination activating 2. (527 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RNF111Ring finger protein 111. (994 aa)
GRB2Uncharacterized protein. (156 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (307 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
ENSCANP00000038603Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (409 aa)
HOMER1Homer scaffold protein 1. (367 aa)
IL6Interleukin 6. (214 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (344 aa)
RASGEF1ARasGEF domain family member 1A. (489 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (180 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
IL10Interleukin 10. (178 aa)
IL7RInterleukin 7 receptor. (458 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (747 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
INSRTyrosine-protein kinase receptor. (1388 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
FOXO1Forkhead box O1. (655 aa)
PIK3R2Uncharacterized protein. (601 aa)
SUCOSUN domain containing ossification factor. (1394 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC105511833Uncharacterized protein. (234 aa)
TPTE2Uncharacterized protein. (522 aa)
S1PR4Sphingosine-1-phosphate receptor 4. (340 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
CREBBPCREB binding protein. (2117 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1336 aa)
ENSCANP00000030691Uncharacterized protein. (78 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC105515123Uncharacterized protein. (307 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
FBXO32F-box protein 32. (360 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
STK4Serine/threonine kinase 4. (487 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
BCL6BBCL6B transcription repressor. (474 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
FBXO25F-box protein 25. (367 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
ENSCANP00000024123Uncharacterized protein. (86 aa)
CSDE1Uncharacterized protein. (844 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (370 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (93 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (587 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2109 aa)
FOXJ2Forkhead box J2. (548 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2548 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
LOC105527785Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1025 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSCANP00000017794Protein kinase domain-containing protein. (345 aa)
SLC35E3Solute carrier family 35 member E3. (313 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RASL11BRAS like family 11 member B. (248 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (259 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
GRM1Glutamate metabotropic receptor 1. (1194 aa)
LOC105504658Uncharacterized protein. (571 aa)
CCNB1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (345 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
EP300E1A binding protein p300. (2409 aa)
HOMER2Homer scaffold protein 2. (306 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
GRAPGRB2 related adaptor protein. (217 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
LOC105515200Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (381 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
ENSCANP00000012327Uncharacterized protein. (178 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (301 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLK3Serine/threonine-protein kinase PLK. (636 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSCANP00000009565Uncharacterized protein. (651 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
FOXJ3Forkhead box J3. (630 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
PLK4Polo like kinase 4. (970 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
PLK5Polo like kinase 5. (336 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
SIRT1Sirtuin 1. (600 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
BNIP3BCL2 interacting protein 3. (185 aa)
FOXO3Forkhead box O3. (544 aa)
TMEM232Transmembrane protein 232. (567 aa)
HOMER3WH1 domain-containing protein. (361 aa)
ENSCANP00000006631Uncharacterized protein. (95 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
RNF6Ring finger protein 6. (701 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FOXO4Forkhead box O4. (505 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
RASGEF1BRasGEF domain family member 1B. (560 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1102 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ENSCANP00000002629Uncharacterized protein. (87 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSCANP00000002057Uncharacterized protein. (147 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ENSCANP00000001858Uncharacterized protein. (151 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
ERASES cell expressed Ras. (233 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
TSSK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (358 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (14%) [HD]