STRINGSTRING
LMLN LMLN ATG4D ATG4D RPS6KB2 RPS6KB2 ATG2A ATG2A ATG13 ATG13 ENSCANP00000039354 ENSCANP00000039354 LAMP1 LAMP1 VAMP8 VAMP8 ULK1 ULK1 ENSCANP00000038908 ENSCANP00000038908 RAB8A RAB8A LOC105513393 LOC105513393 TP53INP2 TP53INP2 RB1CC1 RB1CC1 ZFYVE1 ZFYVE1 PPP1R14B PPP1R14B ATG12 ATG12 PIK3CD PIK3CD HMGB2 HMGB2 PDIK1L PDIK1L RAB33A RAB33A RAB7A RAB7A ATG4A ATG4A EIF2AK4 EIF2AK4 HMGB1 HMGB1 RRAGC RRAGC LOC105511624 LOC105511624 LOC105507813 LOC105507813 PIK3R3 PIK3R3 TSC2 TSC2 MAP2K1 MAP2K1 DAPK1 DAPK1 IRS4 IRS4 RHEB RHEB INS INS GABARAPL2 GABARAPL2 NRBF2 NRBF2 HIF3A HIF3A RAB19 RAB19 RRAS2 RRAS2 RRAGD RRAGD SQSTM1 SQSTM1 DAPK2 DAPK2 CTSL CTSL NPAS3 NPAS3 PIK3R2 PIK3R2 VMP1 VMP1 TPTE2 TPTE2 SNAP29 SNAP29 ENSCANP00000030691 ENSCANP00000030691 PIK3CB PIK3CB ITPR1 ITPR1 PPP2CA PPP2CA TP53INP1 TP53INP1 LOC105522563 LOC105522563 ENSCANP00000029285 ENSCANP00000029285 AKT1S1 AKT1S1 LOC105518589 LOC105518589 RRAGA RRAGA GABARAPL1 GABARAPL1 HIF1A HIF1A DEPTOR DEPTOR AKT3 AKT3 PPP2CB PPP2CB RAB7B RAB7B CFLAR CFLAR PIK3C3 PIK3C3 PRKAA2 PRKAA2 STK11 STK11 MAPK1 MAPK1 GABARAP GABARAP RAB1A RAB1A CTSD CTSD AMBRA1 AMBRA1 ZFYVE28 ZFYVE28 EIF2AK3 EIF2AK3 ATG5 ATG5 SNAP47 SNAP47 CSDE1 CSDE1 PDPK1 PDPK1 BECN1 BECN1 SH3GLB1 SH3GLB1 RAB33B RAB33B ARID4A ARID4A MLST8 MLST8 RIT1 RIT1 ULK2 ULK2 RAB39B RAB39B MTOR MTOR C9orf72 C9orf72 AKT2 AKT2 ATG7 ATG7 PIK3R1 PIK3R1 TSSK4 TSSK4 RASEF RASEF ATG101 ATG101 IGBP1 IGBP1 ENSCANP00000020790 ENSCANP00000020790 RRAD RRAD MAPK8 MAPK8 WIPI1 WIPI1 ENSCANP00000019829 ENSCANP00000019829 ATG16L1 ATG16L1 ATG9B ATG9B DDIT4 DDIT4 MTMR14 MTMR14 NOL4L NOL4L DDIT4L DDIT4L MAPK10 MAPK10 SUPT20HL2 SUPT20HL2 RAF1 RAF1 PRKACA PRKACA WDR41 WDR41 CTSB CTSB TRAF6 TRAF6 STK35 STK35 ERN1 ERN1 ENSCANP00000017794 ENSCANP00000017794 LMLN2 LMLN2 CRYBB3 CRYBB3 ENSCANP00000017321 ENSCANP00000017321 ENSCANP00000017139 ENSCANP00000017139 DUS2 DUS2 RASL11B RASL11B UVRAG UVRAG ATG3 ATG3 MRAS MRAS RIT2 RIT2 PIK3CA PIK3CA ATG14 ATG14 RRAS RRAS MAPK3 MAPK3 LOC105504658 LOC105504658 ATG4C ATG4C CRYGN CRYGN ATG16L2 ATG16L2 AKT1 AKT1 RPS6KB1 RPS6KB1 PRKX PRKX LOC105503372 LOC105503372 ATG4B ATG4B REM1 REM1 KCNK1 KCNK1 RAB43 RAB43 LOC105503143 LOC105503143 DAPK3 DAPK3 BCL2L1 BCL2L1 TSSK2 TSSK2 TBK1 TBK1 ERAS ERAS LOC105506848 LOC105506848 WIPI2 WIPI2 ENSCANP00000001894 ENSCANP00000001894 ENSCANP00000002629 ENSCANP00000002629 LOC105527545 LOC105527545 PIK3R4 PIK3R4 NOL4 NOL4 TSSK6 TSSK6 PRKCD PRKCD ERN2 ERN2 CAMKK2 CAMKK2 ENSCANP00000004477 ENSCANP00000004477 SUPT20H SUPT20H BCL2 BCL2 TSC1 TSC1 RUBCNL RUBCNL PRAP1 PRAP1 BAD BAD MAP3K7 MAP3K7 RRAGB RRAGB HRAS HRAS IRS1 IRS1 TANK TANK LAMP2 LAMP2 KRAS KRAS ENSCANP00000006631 ENSCANP00000006631 RAB39A RAB39A ENSCANP00000013670 ENSCANP00000013670 ATG2B ATG2B RPTOR RPTOR KIAA1671 KIAA1671 ENSCANP00000013095 ENSCANP00000013095 IGF1R IGF1R MTMR3 MTMR3 STX17 STX17 TTC14 TTC14 PRKACB PRKACB BNIP3 BNIP3 RHEBL1 RHEBL1 EIF2S1 EIF2S1 LOC105519940 LOC105519940 PRKCQ PRKCQ ATG10 ATG10 ENSCANP00000009047 ENSCANP00000009047 LOC105510963 LOC105510963 MTMR4 MTMR4 PTEN PTEN SMCR8 SMCR8 MAPK9 MAPK9 ENSCANP00000010820 ENSCANP00000010820 ATG9A ATG9A TSSK3 TSSK3 PRKAA1 PRKAA1 ENSCANP00000012071 ENSCANP00000012071 ENSCANP00000012327 ENSCANP00000012327 GEM GEM MAP2K2 MAP2K2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMLNLeishmanolysin-like peptidase. (659 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (443 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
ATG2AAutophagy related 2A. (1936 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (483 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
LAMP1Lysosomal associated membrane protein 1. (438 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
ENSCANP00000038908Uncharacterized protein. (106 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
LOC105513393Uncharacterized protein. (309 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (179 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (716 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (132 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (180 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
HMGB2High mobility group box 2. (209 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (341 aa)
RAB33ARAB33A, member RAS oncogene family. (237 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1633 aa)
HMGB1Uncharacterized protein. (206 aa)
RRAGCRas related GTP binding C. (320 aa)
LOC105511624Uncharacterized protein. (368 aa)
LOC105507813Uncharacterized protein. (147 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
TSC2TSC complex subunit 2. (1656 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
NRBF2Uncharacterized protein. (180 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (498 aa)
RAB19RAB19, member RAS oncogene family. (217 aa)
RRAS2RAS related 2. (179 aa)
RRAGDRas related GTP binding D. (400 aa)
SQSTM1Sequestosome 1. (440 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
NPAS3Neuronal PAS domain protein 3. (914 aa)
PIK3R2Uncharacterized protein. (601 aa)
VMP1Vacuole membrane protein 1. (398 aa)
TPTE2Uncharacterized protein. (522 aa)
SNAP29Synaptosome associated protein 29. (185 aa)
ENSCANP00000030691Uncharacterized protein. (78 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2697 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
LOC105522563Uncharacterized protein. (203 aa)
ENSCANP00000029285Uncharacterized protein. (143 aa)
AKT1S1AKT1 substrate 1. (276 aa)
LOC105518589Uncharacterized protein. (201 aa)
RRAGARas related GTP binding A. (313 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (452 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
RAB1AUncharacterized protein. (214 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (559 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (887 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SNAP47Synaptosome associated protein 47. (419 aa)
CSDE1Uncharacterized protein. (844 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
BECN1Uncharacterized protein. (451 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
ARID4AAT-rich interaction domain 4A. (1280 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
RIT1Ras like without CAAX 1. (236 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1007 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (688 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
RASEFRAS and EF-hand domain containing. (740 aa)
ATG101Autophagy related 101. (218 aa)
IGBP1Uncharacterized protein. (339 aa)
ENSCANP00000020790Uncharacterized protein. (84 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
ATG16L1Autophagy related 16 like 1. (621 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (898 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
MTMR14Uncharacterized protein. (650 aa)
NOL4LNucleolar protein 4 like. (573 aa)
DDIT4LDNA damage inducible transcript 4 like. (193 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
SUPT20HL2Uncharacterized protein. (786 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (345 aa)
WDR41WD repeat domain 41. (459 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
STK35Serine/threonine kinase 35. (419 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (979 aa)
ENSCANP00000017794Protein kinase domain-containing protein. (345 aa)
LMLN2Leishmanolysin-like peptidase. (771 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
ENSCANP00000017321Uncharacterized protein. (339 aa)
ENSCANP00000017139Uncharacterized protein. (305 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
RASL11BRAS like family 11 member B. (248 aa)
UVRAGUV radiation resistance associated. (699 aa)
ATG3Autophagy-related protein 3. (314 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
RIT2Uncharacterized protein. (162 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATG14Autophagy related 14. (492 aa)
RRASRAS related. (218 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC105504658Uncharacterized protein. (571 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
ATG16L2Autophagy related 16 like 2. (619 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKXProtein kinase X-linked. (304 aa)
LOC105503372Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (362 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (401 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
KCNK1Potassium channel subfamily K member. (336 aa)
RAB43RAB43, member RAS oncogene family. (192 aa)
LOC105503143Uncharacterized protein. (200 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
BCL2L1BCL2 like 1. (233 aa)
TSSK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (358 aa)
TBK1TANK binding kinase 1. (713 aa)
ERASES cell expressed Ras. (233 aa)
LOC105506848Uncharacterized protein. (877 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (440 aa)
ENSCANP00000001894Uncharacterized protein. (215 aa)
ENSCANP00000002629Uncharacterized protein. (87 aa)
LOC105527545Uncharacterized protein. (287 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
NOL4Nucleolar protein 4. (638 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (576 aa)
ENSCANP00000004477Uncharacterized protein. (192 aa)
SUPT20HSPT20 homolog, SAGA complex component. (810 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TSC1TSC complex subunit 1. (1164 aa)
RUBCNLRubicon like autophagy enhancer. (663 aa)
PRAP1Uncharacterized protein. (145 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RRAGBRas related GTP binding B. (374 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSCANP00000006631Uncharacterized protein. (95 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
ENSCANP00000013670Uncharacterized protein. (193 aa)
ATG2BAutophagy related 2B. (2078 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1331 aa)
KIAA1671KIAA1671. (1802 aa)
ENSCANP00000013095Uncharacterized protein. (269 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
MTMR3Myotubularin related protein 3. (1116 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
TTC14Tetratricopeptide repeat domain 14. (771 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
BNIP3BCL2 interacting protein 3. (185 aa)
RHEBL1RHEB like 1. (183 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
LOC105519940Uncharacterized protein. (531 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
ATG10Autophagy related 10. (220 aa)
ENSCANP00000009047HMG box domain-containing protein. (196 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
ENSCANP00000010820PAS domain-containing protein. (213 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (852 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSCANP00000012071Uncharacterized protein. (157 aa)
ENSCANP00000012327Uncharacterized protein. (178 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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