STRINGSTRING
EHMT2 EHMT2 PRKAG2 PRKAG2 CAMK4 CAMK4 ERAS ERAS PPARG PPARG CAMKK2 CAMKK2 ATF2 ATF2 TSC1 TSC1 HRAS HRAS IRS1 IRS1 EIF4EBP1 EIF4EBP1 KRAS KRAS FOXO3 FOXO3 PRKACB PRKACB SOD2 SOD2 RHEBL1 RHEBL1 SIRT1 SIRT1 PRKAB2 PRKAB2 ADCY2 ADCY2 ADIPOR1 ADIPOR1 PRKAA1 PRKAA1 CREB5 CREB5 ENSCANP00000012626 ENSCANP00000012626 IGF1R IGF1R CREB1 CREB1 RPTOR RPTOR RPS6KB1 RPS6KB1 AKT1 AKT1 LOC105504658 LOC105504658 EIF4E1B EIF4E1B PIK3CA PIK3CA ADCY9 ADCY9 ADIPOR2 ADIPOR2 PRKACA PRKACA ENSCANP00000019829 ENSCANP00000019829 IGF1 IGF1 PPARGC1A PPARGC1A ATG101 ATG101 PRKAG3 PRKAG3 PIK3R1 PIK3R1 AKT2 AKT2 MTOR MTOR PTRHD1 PTRHD1 PRKAB1 PRKAB1 ADCY5 ADCY5 CSDE1 CSDE1 ATG5 ATG5 NFKB1 NFKB1 ADCY3 ADCY3 ADIPOQ ADIPOQ CREB3L4 CREB3L4 STK11 STK11 ADCY8 ADCY8 PRKAA2 PRKAA2 EHMT1 EHMT1 LOC105523091 LOC105523091 AKT3 AKT3 EIF4E EIF4E BAX BAX SESN2 SESN2 CREB3L1 CREB3L1 TP53 TP53 AKT1S1 AKT1S1 PIK3CB PIK3CB SESN3 SESN3 APPL1 APPL1 ADCY4 ADCY4 ADCY7 ADCY7 ADCY6 ADCY6 ATF4 ATF4 SESN1 SESN1 PIK3R2 PIK3R2 FOXO1 FOXO1 EIF4E2 EIF4E2 RELA RELA TBCA TBCA CAT CAT ATF6B ATF6B INS INS CREB3L2 CREB3L2 RHEB RHEB IRS4 IRS4 INSR INSR TSC2 TSC2 PIK3R3 PIK3R3 CREB3 CREB3 PIK3CD PIK3CD PRKAG1 PRKAG1 KL KL RB1CC1 RB1CC1 ADCY1 ADCY1 CREB3L3 CREB3L3 ENSCANP00000038908 ENSCANP00000038908 ULK1 ULK1 ATG13 ATG13 RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (544 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (448 aa)
ERASES cell expressed Ras. (233 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (576 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TSC1TSC complex subunit 1. (1164 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FOXO3Forkhead box O3. (544 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
RHEBL1RHEB like 1. (183 aa)
SIRT1Sirtuin 1. (600 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1014 aa)
ADIPOR1Adiponectin receptor 1. (258 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ENSCANP00000012626Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (109 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1331 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105504658Uncharacterized protein. (571 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (345 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
IGF1Insulin like growth factor 1. (208 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
ATG101Autophagy related 101. (218 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
CSDE1Uncharacterized protein. (844 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (427 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1291 aa)
LOC105523091Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
SESN2Sestrin 2. (479 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
SESN3Sestrin 3. (522 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (658 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1083 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
SESN1Sestrin 1. (551 aa)
PIK3R2Uncharacterized protein. (601 aa)
FOXO1Forkhead box O1. (655 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ATF6BActivating transcription factor 6 beta. (690 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (461 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
INSRTyrosine-protein kinase receptor. (1388 aa)
TSC2TSC complex subunit 2. (1656 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (344 aa)
KLKlotho. (896 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (976 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (415 aa)
ENSCANP00000038908Uncharacterized protein. (106 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (483 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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