STRINGSTRING
ID3 ID3 MATN2 MATN2 SMAD3 SMAD3 BAMBI BAMBI TGIF2 TGIF2 HAMP HAMP SNAPIN SNAPIN RBX1 RBX1 USF2 USF2 ZFYVE16 ZFYVE16 NOG NOG E2F5 E2F5 TGFBR2 TGFBR2 GREM2 GREM2 LOC105521177 LOC105521177 INHBA INHBA ACVR2A ACVR2A SMAD7 SMAD7 FST FST BMP5 BMP5 RHOA RHOA BMPR1B BMPR1B ACVR1C ACVR1C FBN3 FBN3 TGFB1 TGFB1 BMP6 BMP6 RHOC RHOC LOC105510963 LOC105510963 SMAD9 SMAD9 CUL1 CUL1 FSTL3 FSTL3 CHRD CHRD LTBP2 LTBP2 FMOD FMOD RGMA RGMA FBN2 FBN2 ENSCANP00000012853 ENSCANP00000012853 ACVR1 ACVR1 BMP2 BMP2 BMPR1A BMPR1A TGIF1 TGIF1 GDF7 GDF7 BMP4 BMP4 GDF6 GDF6 RPS6KB1 RPS6KB1 DCN DCN PITX1 PITX1 EP300 EP300 IFNG IFNG PITX2 PITX2 MAPK3 MAPK3 ROCK1 ROCK1 SMAD5 SMAD5 LDAH LDAH ANKFN1 ANKFN1 SMAD1 SMAD1 NBL1 NBL1 ENSCANP00000018891 ENSCANP00000018891 PITX3 PITX3 RGMB RGMB AMHR2 AMHR2 TGFB2 TGFB2 THBS1 THBS1 TNF TNF ACVR1B ACVR1B ENSCANP00000022999 ENSCANP00000022999 RPS6KB2 RPS6KB2 RBL1 RBL1 INHBC INHBC TFDP1 TFDP1 CDKN2B CDKN2B ID1 ID1 SMAD2 SMAD2 LTBP3 LTBP3 PPP2R1B PPP2R1B NEO1 NEO1 NODAL NODAL ENSCANP00000033944 ENSCANP00000033944 LOC105516700 LOC105516700 LTBP1 LTBP1 HJV HJV MATN4 MATN4 BMPR2 BMPR2 TGFB3 TGFB3 BMP8B BMP8B ID2 ID2 CREBBP CREBBP INHBE INHBE PPP2R1A PPP2R1A MYC MYC TGFBR1 TGFBR1 PPP2CA PPP2CA FBN1 FBN1 SMAD4 SMAD4 SMURF1 SMURF1 PKNOX1 PKNOX1 SKP1 SKP1 PPP2CB PPP2CB LOC105516701 LOC105516701 ACVR2B ACVR2B SP1 SP1 ENSCANP00000026743 ENSCANP00000026743 MAPK1 MAPK1 SMURF2 SMURF2 ZFYVE9 ZFYVE9 ENSCANP00000025746 ENSCANP00000025746 INTS8 INTS8 E2F4 E2F4 THSD4 THSD4 GDF5 GDF5 LTBP4 LTBP4 PKNOX2 PKNOX2 ADAMTSL4 ADAMTSL4 BMP7 BMP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
MATN2Matrilin 2. (956 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
RBX1Ring-box 1. (108 aa)
USF2Upstream transcription factor 2, c-fos interacting. (218 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1537 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
E2F5E2F transcription factor 5. (343 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GREM2Gremlin. (168 aa)
LOC105521177TGF_BETA_2 domain-containing protein. (238 aa)
INHBAInhibin subunit beta A. (426 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
FSTFollistatin. (317 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
RHOARas homolog family member A. (193 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
FBN3Fibrillin 3. (2790 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
RHOCRas homolog family member C. (193 aa)
LOC105510963Serine/threonine-protein phosphatase. (291 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
FSTL3Kazal-like domain-containing protein. (70 aa)
CHRDChordin. (871 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
FMODFibromodulin. (376 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
FBN2Fibrillin 2. (2912 aa)
ENSCANP00000012853C2 domain-containing protein. (51 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGIF1TGFB induced factor homeobox 1. (392 aa)
GDF7Growth differentiation factor 7. (366 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF6Growth differentiation factor 6. (455 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
PITX1Homeobox protein. (298 aa)
EP300E1A binding protein p300. (2409 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
PITX2Homeobox protein. (325 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LDAHLipid droplet associated hydrolase. (324 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (1149 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
NBL1NBL1, DAN family BMP antagonist. (215 aa)
ENSCANP00000018891Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
PITX3Homeobox protein. (302 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (401 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
THBS1Thrombospondin 1. (1173 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ENSCANP00000022999Homeobox domain-containing protein. (276 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
RBL1RB transcriptional corepressor like 1. (959 aa)
INHBCInhibin subunit beta C. (352 aa)
TFDP1Transcription factor. (410 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1127 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
NEO1Neogenin 1. (1451 aa)
NODALNodal growth differentiation factor. (347 aa)
ENSCANP00000033944Uncharacterized protein; Belongs to the SKP1 family. (131 aa)
LOC105516700TGF_BETA_2 domain-containing protein. (311 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1510 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
MATN4Matrilin 4. (622 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP8BTGF_BETA_2 domain-containing protein. (336 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
CREBBPCREB binding protein. (2117 aa)
INHBEInhibin subunit beta E. (351 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (594 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
FBN1Fibrillin 1. (2816 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMURF1E3 ubiquitin-protein ligase. (763 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
LOC105516701TGF_BETA_2 domain-containing protein. (283 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
SP1Sp1 transcription factor. (718 aa)
ENSCANP00000026743Transcription factor. (322 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
SMURF2E3 ubiquitin-protein ligase. (734 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1409 aa)
ENSCANP00000025746Uncharacterized protein; Belongs to the SKP1 family. (167 aa)
INTS8Integrator complex subunit 8. (898 aa)
E2F4E2F transcription factor 4. (370 aa)
THSD4Thrombospondin type 1 domain containing 4. (1017 aa)
GDF5Growth differentiation factor 5. (499 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1599 aa)
PKNOX2PBX/knotted 1 homeobox 2. (472 aa)
ADAMTSL4ADAMTS like 4. (1099 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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