STRINGSTRING
AKT1 AKT1 MITF MITF TNFRSF11A TNFRSF11A MAPK3 MAPK3 JAK1 JAK1 GRB2 GRB2 MAPK14 MAPK14 PPP3CC PPP3CC ENSCANP00000039354 ENSCANP00000039354 TRAF2 TRAF2 SPI1 SPI1 LCK LCK LILRA5 LILRA5 IFNGR2 IFNGR2 FCGR2A FCGR2A PIK3CD PIK3CD IKBKG IKBKG LOC105512778 LOC105512778 IFNAR2 IFNAR2 TNFRSF1A TNFRSF1A FOSB FOSB PTK6 PTK6 PIK3R3 PIK3R3 MAP2K1 MAP2K1 IL1A IL1A LOC105504899 LOC105504899 FOSL1 FOSL1 MAPK13 MAPK13 LOC105519602 LOC105519602 ACP5 ACP5 NCF4 NCF4 RELA RELA NCF1 NCF1 SQSTM1 SQSTM1 PIK3R2 PIK3R2 JUN JUN IL1B IL1B MAP3K14 MAP3K14 PIK3CB PIK3CB TGFBR1 TGFBR1 FCGR2B FCGR2B BTK BTK PPP3CA PPP3CA IFNB1 IFNB1 AKT3 AKT3 TEC TEC BLNK BLNK STAT1 STAT1 MAPK1 MAPK1 TAB2 TAB2 GAB4 GAB4 IFNGR1 IFNGR1 NFKB1 NFKB1 IRF9 IRF9 ITGB3 ITGB3 LCP2 LCP2 CYBA CYBA CYLD CYLD TNF TNF AKT2 AKT2 PIK3R1 PIK3R1 TGFB2 TGFB2 MAPK8 MAPK8 PPP3R2 PPP3R2 TYK2 TYK2 SRMS SRMS FOS FOS MAPK10 MAPK10 PPP3R1 PPP3R1 TNFRSF11B TNFRSF11B NFKB2 NFKB2 FYN FYN SYK SYK TRAF6 TRAF6 LOC105504904 LOC105504904 TAB1 TAB1 RELCH RELCH LILRA6 LILRA6 CSF1R CSF1R PIK3CA PIK3CA ENSCANP00000016194 ENSCANP00000016194 CAMK4 CAMK4 JUNB JUNB STAT2 STAT2 FCGR1A FCGR1A MAPK11 MAPK11 NOXA1 NOXA1 PPARG PPARG MAP2K7 MAP2K7 PLCG2 PLCG2 CTSK CTSK TREM2 TREM2 TGFBR2 TGFBR2 SOCS3 SOCS3 MAP3K7 MAP3K7 CHUK CHUK NOX1 NOX1 PPP3CB PPP3CB MAP2K6 MAP2K6 IFNAR1 IFNAR1 NFKBIA NFKBIA FHL2 FHL2 LILRA4 LILRA4 NCF2 NCF2 NFATC2 NFATC2 TGFB1 TGFB1 ENSCANP00000009062 ENSCANP00000009062 LILRB4 LILRB4 NFATC1 NFATC1 MAPK9 MAPK9 IKBKB IKBKB SIRPD SIRPD IGSF1 IGSF1 CALCR CALCR RELB RELB FOSL2 FOSL2 LOC105504881 LOC105504881 ENSCANP00000012498 ENSCANP00000012498 CSF1 CSF1 LOC105512773 LOC105512773 TYROBP TYROBP SIRPG SIRPG CREB1 CREB1 MAPK12 MAPK12 TNFSF11 TNFSF11 IL1R1 IL1R1 GAB2 GAB2 IFNG IFNG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
TNFRSF11ATNF receptor superfamily member 11a. (712 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
GRB2Uncharacterized protein. (156 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP3CCSerine/threonine-protein phosphatase. (499 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
LCKTyrosine-protein kinase. (539 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
IFNGR2Interferon gamma receptor 2. (231 aa)
FCGR2AUncharacterized protein. (316 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
LOC105512778Uncharacterized protein. (397 aa)
IFNAR2Uncharacterized protein. (516 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
LOC105504899Uncharacterized protein. (632 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
LOC105519602Ig-like domain-containing protein. (290 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
SQSTM1Sequestosome 1. (440 aa)
PIK3R2Uncharacterized protein. (601 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
FCGR2BUncharacterized protein. (306 aa)
BTKTyrosine-protein kinase. (692 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IFNB1Interferon beta 1. (187 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TECTyrosine-protein kinase. (630 aa)
BLNKB cell linker. (456 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
GAB4GRB2 associated binding protein family member 4. (436 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
IRF9Interferon regulatory factor 9. (393 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP3R2Protein phosphatase 3 regulatory subunit B, beta. (174 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
SRMSTyrosine-protein kinase. (492 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PPP3R1Uncharacterized protein. (189 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
FYNTyrosine-protein kinase. (537 aa)
SYKTyrosine-protein kinase. (635 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LOC105504904Uncharacterized protein. (599 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
LILRA6Ig-like domain-containing protein. (481 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCANP00000016194Uncharacterized protein. (202 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (448 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
STAT2Signal transducer and activator of transcription. (708 aa)
FCGR1AUncharacterized protein. (373 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
NOXA1NADPH oxidase activator 1. (424 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
NOX1NADPH oxidase 1. (522 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (540 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
FHL2Four and a half LIM domains 2. (363 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (500 aa)
NCF2Neutrophil cytosolic factor 2. (498 aa)
NFATC2Nuclear factor of activated T cells 2. (923 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
ENSCANP00000009062IGc1 domain-containing protein. (178 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (448 aa)
NFATC1Nuclear factor of activated T cells 1. (815 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
SIRPDSignal regulatory protein delta. (197 aa)
IGSF1Immunoglobulin superfamily member 1. (1341 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (492 aa)
RELBRELB proto-oncogene, NF-kB subunit. (467 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (309 aa)
LOC105504881Uncharacterized protein. (618 aa)
ENSCANP00000012498Ig-like domain-containing protein. (212 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
LOC105512773Uncharacterized protein. (507 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (123 aa)
SIRPGSignal regulatory protein gamma. (354 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (317 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
GAB2GRB2 associated binding protein 2. (655 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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