STRINGSTRING
MAPK8 MAPK8 PRKCD PRKCD HRAS HRAS CHUK CHUK PAK1 PAK1 KRAS KRAS PPP3CB PPP3CB NFATC2 NFATC2 LOC105507867 LOC105507867 RHOC RHOC ENSCANP00000009406 ENSCANP00000009406 NFATC3 NFATC3 PLK3 PLK3 NFATC1 NFATC1 MAPK9 MAPK9 ENSCANP00000010831 ENSCANP00000010831 IKBKB IKBKB CEACAM16 CEACAM16 ENSCANP00000011220 ENSCANP00000011220 LSP1 LSP1 FCER1G FCER1G RELB RELB GEM GEM CASP8 CASP8 CLEC7A CLEC7A CLEC1B CLEC1B MAPK12 MAPK12 CALML6 CALML6 LOC105525017 LOC105525017 AKT1 AKT1 CALM3 CALM3 LOC105504658 LOC105504658 CEACAM8 CEACAM8 MAPK3 MAPK3 EGR3 EGR3 PYCARD PYCARD RRAS RRAS PIK3CA PIK3CA MRAS MRAS EFCAB13 EFCAB13 CCL17 CCL17 SYK SYK NFKB2 NFKB2 NFATC4 NFATC4 RAF1 RAF1 CLEC6A CLEC6A PPP3R1 PPP3R1 MAPK10 MAPK10 TMEM52B TMEM52B PTGS2 PTGS2 CLEC4E CLEC4E ENSCANP00000019353 ENSCANP00000019353 CLEC9A CLEC9A ENSCANP00000019829 ENSCANP00000019829 PPP3R2 PPP3R2 LOC105507871 LOC105507871 CALML3 CALML3 RRAD RRAD MALT1 MALT1 PIK3R1 PIK3R1 AKT2 AKT2 TNF TNF CYLD CYLD CEACAM4 CEACAM4 ITPR3 ITPR3 CLEC4G CLEC4G CSDE1 CSDE1 ENSCANP00000023404 ENSCANP00000023404 LOC105507867-2 LOC105507867-2 IRF9 IRF9 CLEC4D CLEC4D NFKB1 NFKB1 CALM2 CALM2 IL2 IL2 CASP1 CASP1 CBLB CBLB ENSCANP00000025796 ENSCANP00000025796 MAPK1 MAPK1 STAT1 STAT1 CALML4 CALML4 AKT3 AKT3 ENSCANP00000028447 ENSCANP00000028447 IKBKE IKBKE IRF1 IRF1 CEACAM7 CEACAM7 PPP3CA PPP3CA ITPR1 ITPR1 LOC105500957 LOC105500957 PIK3CB PIK3CB EGR2 EGR2 MAP3K14 MAP3K14 CEACAM1 CEACAM1 IL1B IL1B JUN JUN CCL22 CCL22 PIK3R2 PIK3R2 RRAS2 RRAS2 RELA RELA CLEC4A CLEC4A CD209 CD209 PTPN11 PTPN11 MAPK13 MAPK13 IL12B IL12B MAPKAPK2 MAPKAPK2 PVALEF PVALEF ENSCANP00000034842 ENSCANP00000034842 ENSCANP00000034934 ENSCANP00000034934 KSR1 KSR1 PIK3R3 PIK3R3 EFCAB3 EFCAB3 ENSCANP00000036145 ENSCANP00000036145 IL10 IL10 IKBKG IKBKG NLRP3 NLRP3 IL12A IL12A PIK3CD PIK3CD ITPR2 ITPR2 LOC105525018 LOC105525018 IL6 IL6 BCL3 BCL3 ARHGEF12 ARHGEF12 PPP3CC PPP3CC MAPK14 MAPK14 SRC SRC IL23A IL23A NFKBIA NFKBIA RHOA RHOA PLK5 PLK5 BCL10 BCL10 REM1 REM1 LOC105526953 LOC105526953 LOC105525024 LOC105525024 STAT2 STAT2 ERAS ERAS MAPK11 MAPK11 PLCG2 PLCG2 LOC105525015 LOC105525015 ENSCANP00000002557 ENSCANP00000002557 CARD9 CARD9 CALM1 CALM1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
NFATC2Nuclear factor of activated T cells 2. (923 aa)
LOC105507867IGv domain-containing protein. (252 aa)
RHOCRas homolog family member C. (193 aa)
ENSCANP00000009406Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
NFATC3Nuclear factor of activated T cells 3. (1067 aa)
PLK3Serine/threonine-protein kinase PLK. (636 aa)
NFATC1Nuclear factor of activated T cells 1. (815 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
ENSCANP00000010831Uncharacterized protein. (333 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (425 aa)
ENSCANP00000011220Uncharacterized protein. (277 aa)
LSP1Lymphocyte specific protein 1. (445 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
RELBRELB proto-oncogene, NF-kB subunit. (467 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
CALML6Calmodulin like 6. (181 aa)
LOC105525017Uncharacterized protein. (424 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
CALM3Calmodulin 3. (149 aa)
LOC105504658Uncharacterized protein. (571 aa)
CEACAM8Carcinoembryonic antigen related cell adhesion molecule 8. (351 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
EGR3Early growth response 3. (387 aa)
PYCARDPYD and CARD domain containing. (195 aa)
RRASRAS related. (218 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
EFCAB13EF-hand calcium binding domain 13. (973 aa)
CCL17C-C motif chemokine. (93 aa)
SYKTyrosine-protein kinase. (635 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
NFATC4Nuclear factor of activated T cells 4. (918 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
PPP3R1Uncharacterized protein. (189 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
TMEM52BTransmembrane protein 52B. (182 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
ENSCANP00000019353Uncharacterized protein. (344 aa)
CLEC9AC-type lectin domain containing 9A. (241 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
PPP3R2Protein phosphatase 3 regulatory subunit B, beta. (174 aa)
LOC105507871Uncharacterized protein. (429 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MALT1MALT1 paracaspase. (778 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
CEACAM4Carcinoembryonic antigen related cell adhesion molecule 4. (244 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
CSDE1Uncharacterized protein. (844 aa)
ENSCANP00000023404Uncharacterized protein. (400 aa)
LOC105507867-2Ig-like domain-containing protein. (283 aa)
IRF9Interferon regulatory factor 9. (393 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
CALM2Calmodulin 2. (149 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (372 aa)
CBLBCbl proto-oncogene B. (982 aa)
ENSCANP00000025796Uncharacterized protein. (269 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
CALML4Calmodulin like 4. (192 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSCANP00000028447Uncharacterized protein; Belongs to the calmodulin family. (173 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (636 aa)
IRF1Interferon regulatory factor. (325 aa)
CEACAM7Carcinoembryonic antigen related cell adhesion molecule 7. (264 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2697 aa)
LOC105500957Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
EGR2Early growth response 2. (476 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
CEACAM1Uncharacterized protein. (525 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
CCL22C-C motif chemokine. (93 aa)
PIK3R2Uncharacterized protein. (601 aa)
RRAS2RAS related 2. (179 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
CLEC4AC-type lectin domain family 4 member A. (239 aa)
CD209CD209 molecule. (392 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (431 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ENSCANP00000034842Ig-like domain-containing protein. (329 aa)
ENSCANP00000034934SH2 domain-containing protein. (183 aa)
KSR1Kinase suppressor of ras 1. (867 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
ENSCANP00000036145Uncharacterized protein. (268 aa)
IL10Interleukin 10. (178 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
LOC105525018Uncharacterized protein. (426 aa)
IL6Interleukin 6. (214 aa)
BCL3BCL3 transcription coactivator. (381 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1471 aa)
PPP3CCSerine/threonine-protein phosphatase. (499 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SRCTyrosine-protein kinase. (458 aa)
IL23AInterleukin 23 subunit alpha. (200 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
RHOARas homolog family member A. (193 aa)
PLK5Polo like kinase 5. (336 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
LOC105526953Uncharacterized protein. (426 aa)
LOC105525024Uncharacterized protein. (404 aa)
STAT2Signal transducer and activator of transcription. (708 aa)
ERASES cell expressed Ras. (233 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
LOC105525015Uncharacterized protein. (409 aa)
ENSCANP00000002557Uncharacterized protein. (535 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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