STRINGSTRING
MAP3K8 MAP3K8 GRB2 GRB2 MAPK14 MAPK14 PPP3CC PPP3CC ENSCANP00000039354 ENSCANP00000039354 LAT LAT PAK6 PAK6 PDCD1 PDCD1 LCK LCK VAV3 VAV3 CDC42 CDC42 ZAP70 ZAP70 CD3E CD3E CD4 CD4 PIK3CD PIK3CD IKBKG IKBKG IL10 IL10 SOS2 SOS2 PTK6 PTK6 PIK3R3 PIK3R3 MAP2K1 MAP2K1 DLG1 DLG1 CD40LG CD40LG CD3G CD3G MAPK13 MAPK13 IL5 IL5 SOS1 SOS1 RELA RELA NCK1 NCK1 PIK3R2 PIK3R2 ITK ITK JUN JUN MAP3K14 MAP3K14 RASGRP1 RASGRP1 CTLA4 CTLA4 PAK2 PAK2 PIK3CB PIK3CB CD3D CD3D PPP3CA PPP3CA CD28 CD28 AKT3 AKT3 TEC TEC PTPN6 PTPN6 MAPK1 MAPK1 CD8A CD8A CARD11 CARD11 CD8B CD8B CBLB CBLB PAK3 PAK3 IL2 IL2 NFKB1 NFKB1 PAK5 PAK5 LCP2 LCP2 CSDE1 CSDE1 PDPK1 PDPK1 IL4 IL4 ICOS ICOS TRAC TRAC TNF TNF AKT2 AKT2 PIK3R1 PIK3R1 MALT1 MALT1 MAPK8 MAPK8 PPP3R2 PPP3R2 NFKBIB NFKBIB ENSCANP00000019829 ENSCANP00000019829 SRMS SRMS FOS FOS MAPK10 MAPK10 PPP3R1 PPP3R1 RAF1 RAF1 FYN FYN PIK3CA PIK3CA VAV1 VAV1 PTPRC PTPRC CD247 CD247 MAPK3 MAPK3 LOC105504658 LOC105504658 AKT1 AKT1 IFNG IFNG CDK4 CDK4 MAPK12 MAPK12 ENSCANP00000013076 ENSCANP00000013076 MAP2K2 MAP2K2 CSF2 CSF2 NCK2 NCK2 PLCG1 PLCG1 ENSCANP00000011118 ENSCANP00000011118 GSK3B GSK3B IKBKB IKBKB MAPK9 MAPK9 NFATC1 NFATC1 NFATC3 NFATC3 RHOC RHOC PRKCQ PRKCQ NFATC2 NFATC2 VAV2 VAV2 PAK4 PAK4 RHOA RHOA NFKBIA NFKBIA PPP3CB PPP3CB KRAS KRAS PAK1 PAK1 GRAP2 GRAP2 NFKBIE NFKBIE CHUK CHUK HRAS HRAS MAP3K7 MAP3K7 ENSCANP00000005072 ENSCANP00000005072 TRAV22 TRAV22 MAP2K7 MAP2K7 MAPK11 MAPK11 ERAS ERAS BCL10 BCL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
GRB2Uncharacterized protein. (156 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP3CCSerine/threonine-protein phosphatase. (499 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
LATLinker for activation of T cells. (254 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
PDCD1Programmed cell death 1. (293 aa)
LCKTyrosine-protein kinase. (539 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
CDC42Cell division cycle 42. (191 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CD3ECD3e molecule. (198 aa)
CD4CD4 molecule. (458 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
IL10Interleukin 10. (178 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
CD3GCD3g molecule. (181 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3R2Uncharacterized protein. (601 aa)
ITKTyrosine-protein kinase. (620 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
RASGRP1RAS guanyl releasing protein 1. (793 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
CD3DCD3d molecule. (171 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CD28CD28 molecule. (220 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TECTyrosine-protein kinase. (630 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CD8ACD8a molecule. (235 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
CD8BIg-like domain-containing protein. (228 aa)
CBLBCbl proto-oncogene B. (982 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
CSDE1Uncharacterized protein. (844 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ICOSInducible T cell costimulator. (199 aa)
TRACT cell receptor alpha constant. (110 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MALT1MALT1 paracaspase. (778 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP3R2Protein phosphatase 3 regulatory subunit B, beta. (174 aa)
NFKBIBNFKB inhibitor beta. (321 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
SRMSTyrosine-protein kinase. (492 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PPP3R1Uncharacterized protein. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VAV1Vav guanine nucleotide exchange factor 1. (740 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1311 aa)
CD247CD247 molecule. (163 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC105504658Uncharacterized protein. (571 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
ENSCANP00000013076Uncharacterized protein. (164 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
CSF2Colony stimulating factor 2. (144 aa)
NCK2Cytoplasmic protein. (380 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
ENSCANP00000011118Uncharacterized protein. (176 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
NFATC1Nuclear factor of activated T cells 1. (815 aa)
NFATC3Nuclear factor of activated T cells 3. (1067 aa)
RHOCRas homolog family member C. (193 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
NFATC2Nuclear factor of activated T cells 2. (923 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
PAK4Non-specific serine/threonine protein kinase. (597 aa)
RHOARas homolog family member A. (193 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
NFKBIENFKB inhibitor epsilon. (487 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSCANP00000005072Uncharacterized protein. (168 aa)
TRAV22T cell receptor alpha variable 22. (147 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
ERASES cell expressed Ras. (233 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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