STRINGSTRING
RELA RELA MMP9 MMP9 MAPK13 MAPK13 DNM1L DNM1L MMP10 MMP10 ATF6B ATF6B CREB3L2 CREB3L2 MAP2K1 MAP2K1 CCL5 CCL5 PIK3R3 PIK3R3 TNFRSF1A TNFRSF1A CREB3 CREB3 IL15 IL15 IKBKG IKBKG PIK3CD PIK3CD CREB3L3 CREB3L3 IL6 IL6 MMP14 MMP14 CCDC88B CCDC88B BCL3 BCL3 TRAF2 TRAF2 LOC105501292 LOC105501292 ENSCANP00000039354 ENSCANP00000039354 RPS6KA4 RPS6KA4 RPS6KA5 RPS6KA5 MAPK14 MAPK14 FAS FAS CASP3 CASP3 EDN1 EDN1 JUNB JUNB MAPK11 MAPK11 MAP2K7 MAP2K7 LIF LIF ITCH ITCH CCL20 CCL20 BIRC2 BIRC2 SOCS3 SOCS3 ATF2 ATF2 MAP3K7 MAP3K7 CHUK CHUK TRAF1 TRAF1 CCL2 CCL2 SELE SELE ENSCANP00000006830 ENSCANP00000006830 MAP2K6 MAP2K6 NFKBIA NFKBIA TAB3 TAB3 RIPK1 RIPK1 MMP3 MMP3 MAPK9 MAPK9 CXCL6 CXCL6 IKBKB IKBKB CEACAM16 CEACAM16 CX3CL1 CX3CL1 VEGFC VEGFC CSF2 CSF2 CREB5 CREB5 CASP8 CASP8 CSF1 CSF1 LOC105501293 LOC105501293 RFWD3 RFWD3 FADD FADD CREB1 CREB1 MAPK12 MAPK12 BAG4 BAG4 AKT1 AKT1 LOC105501296 LOC105501296 MAPK3 MAPK3 TRAF5 TRAF5 DAB2IP DAB2IP PIK3CA PIK3CA MAP2K3 MAP2K3 TAB1 TAB1 LTA LTA MAPK10 MAPK10 FOS FOS PTGS2 PTGS2 MAP3K8 MAP3K8 CASP7 CASP7 TRADD TRADD MAPK8 MAPK8 PIK3R1 PIK3R1 AKT2 AKT2 TNF TNF CXCL10 CXCL10 MAP2K4 MAP2K4 CXCL2 CXCL2 NFKB1 NFKB1 CXCL1 CXCL1 VEGFD VEGFD BIRC3 BIRC3 MAP3K5 MAP3K5 CASP10 CASP10 JAG1 JAG1 TAB2 TAB2 MAPK1 MAPK1 CREB3L4 CREB3L4 PGAM5 PGAM5 TNFRSF1B TNFRSF1B TNFAIP3 TNFAIP3 CFLAR CFLAR AKT3 AKT3 ENSCANP00000040251 ENSCANP00000040251 IL18R1 IL18R1 CREB3L1 CREB3L1 IRF1 IRF1 TRAF3 TRAF3 IFNB1 IFNB1 NOD2 NOD2 PIK3CB PIK3CB MAP3K14 MAP3K14 ATF4 ATF4 IL1B IL1B ICAM1 ICAM1 JUN JUN RIPK3 RIPK3 PIK3R2 PIK3R2 VCAM1 VCAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (752 aa)
MMP10Matrix metallopeptidase 10. (476 aa)
ATF6BActivating transcription factor 6 beta. (690 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCL5C-C motif chemokine. (91 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (415 aa)
IL6Interleukin 6. (214 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CCDC88BCoiled-coil domain containing 88B. (1434 aa)
BCL3BCL3 transcription coactivator. (381 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
LOC105501292C-X-C motif chemokine. (112 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
RPS6KA4Ribosomal protein S6 kinase. (755 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FASFas cell surface death receptor. (331 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
EDN1Endothelin 1. (211 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
CCL20C-C motif chemokine. (96 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TRAF1TNF receptor-associated factor. (416 aa)
CCL2C-C motif chemokine. (99 aa)
SELESelectin E. (612 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (625 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
CXCL6C-X-C motif chemokine. (114 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (425 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (459 aa)
CSF2Colony stimulating factor 2. (144 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
LOC105501293C-X-C motif chemokine. (107 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (200 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105501296C-X-C motif chemokine. (114 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (379 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CXCL10C-X-C motif chemokine. (98 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
CXCL2C-X-C motif chemokine. (107 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
CXCL1C-X-C motif chemokine. (107 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1364 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (484 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (427 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (239 aa)
TNFRSF1BTNF receptor superfamily member 1B. (445 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (452 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSCANP00000040251Uncharacterized protein; Belongs to the peptidase C14A family. (243 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
IRF1Interferon regulatory factor. (325 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IFNB1Interferon beta 1. (187 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
ATF4Activating transcription factor 4. (351 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
PIK3R2Uncharacterized protein. (601 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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