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MAP2K1 MAP2K1 CACNA1D CACNA1D REM1 REM1 ERAS ERAS MAPK11 MAPK11 MAP2K7 MAP2K7 PRKCA PRKCA PLCB2 PLCB2 CALM1 CALM1 MAP3K2 MAP3K2 LOC105507704 LOC105507704 PLA2G4D PLA2G4D CALML3 CALML3 PRKCD PRKCD PLD2 PLD2 ENSCANP00000005072 ENSCANP00000005072 HRAS HRAS MAPK7 MAPK7 HBEGF HBEGF GNAQ GNAQ KRAS KRAS ENSCANP00000006830 ENSCANP00000006830 MAP2K6 MAP2K6 ELK1 ELK1 PRKACB PRKACB GNRHR GNRHR MAP3K3 MAP3K3 ELK3 ELK3 ENSCANP00000009406 ENSCANP00000009406 ADCY2 ADCY2 MAPK9 MAPK9 CACNA1S CACNA1S ENSCANP00000011118 ENSCANP00000011118 PTK2B PTK2B GEM GEM MAP2K2 MAP2K2 ENSCANP00000013076 ENSCANP00000013076 MAPK12 MAPK12 PLD1 PLD1 CAMK2A CAMK2A CALML6 CALML6 CALM3 CALM3 LOC105504658 LOC105504658 MAPK3 MAPK3 CACNA1F CACNA1F PLA2G4E PLA2G4E LHB LHB MAP2K3 MAP2K3 EFCAB13 EFCAB13 MAP3K4 MAP3K4 ADCY9 ADCY9 CAMK2D CAMK2D CAMK2B CAMK2B PRKACA PRKACA EGFR EGFR RAF1 RAF1 MAPK10 MAPK10 ENSCANP00000018979 ENSCANP00000018979 PLA2G4A PLA2G4A ENSCANP00000019829 ENSCANP00000019829 MAPK8 MAPK8 RRAD RRAD FSHB FSHB GNAS GNAS LOC105518331 LOC105518331 ARSI ARSI PTRHD1 PTRHD1 MAP2K4 MAP2K4 PRKCB PRKCB JMJD7 JMJD7 ITPR3 ITPR3 ADCY5 ADCY5 CSDE1 CSDE1 CALM2 CALM2 GNRH2 GNRH2 MAP3K1 MAP3K1 ADCY3 ADCY3 MAPK1 MAPK1 ADCY8 ADCY8 CALML4 CALML4 CGA CGA ENSCANP00000028447 ENSCANP00000028447 ITPR1 ITPR1 ADCY4 ADCY4 ADCY7 ADCY7 ADCY6 ADCY6 ATF4 ATF4 JUN JUN LOC105506399 LOC105506399 PLA2G4F PLA2G4F CACNA1C CACNA1C SOS1 SOS1 MAPK13 MAPK13 PVALEF PVALEF PLCB4 PLCB4 PLA2G4B PLA2G4B EGR1 EGR1 CAMK2G CAMK2G EFCAB3 EFCAB3 GNRH1 GNRH1 LOC105514782 LOC105514782 PLA2G4C PLA2G4C SOS2 SOS2 PLCB1 PLCB1 PTX3 PTX3 ITPR2 ITPR2 ADCY1 ADCY1 CDC42 CDC42 MMP14 MMP14 ENSCANP00000039354 ENSCANP00000039354 MAPK14 MAPK14 PLCB3 PLCB3 SRC SRC GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
ERASES cell expressed Ras. (233 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (639 aa)
LOC105507704ETS domain-containing protein. (403 aa)
PLA2G4DPhospholipase A2. (794 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PLD2Phospholipase. (859 aa)
ENSCANP00000005072Uncharacterized protein. (168 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
GNAQG protein subunit alpha q. (313 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ELK1ETS domain-containing protein. (428 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
ELK3ETS transcription factor ELK3. (407 aa)
ENSCANP00000009406Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1014 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
ENSCANP00000011118Uncharacterized protein. (176 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
ENSCANP00000013076Uncharacterized protein. (164 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
PLD1Phospholipase. (971 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CALML6Calmodulin like 6. (181 aa)
CALM3Calmodulin 3. (149 aa)
LOC105504658Uncharacterized protein. (571 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1971 aa)
PLA2G4EPhospholipase A2. (869 aa)
LHBCys_knot domain-containing protein. (141 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
EFCAB13EF-hand calcium binding domain 13. (973 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1586 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (345 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
ENSCANP00000018979Cys_knot domain-containing protein. (84 aa)
PLA2G4APhospholipase A2. (749 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
GNASGNAS complex locus. (913 aa)
LOC105518331G_PROTEIN_RECEP_F1_2 domain-containing protein. (379 aa)
ARSIArylsulfatase family member I. (569 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
JMJD7Jumonji domain containing 7. (316 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
CSDE1Uncharacterized protein. (844 aa)
CALM2Calmodulin 2. (149 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (118 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1356 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALML4Calmodulin like 4. (192 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
ENSCANP00000028447Uncharacterized protein; Belongs to the calmodulin family. (173 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2697 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1083 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
LOC105506399Uncharacterized protein. (246 aa)
PLA2G4FPhospholipase A2. (791 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2134 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLA2G4BPhospholipase A2. (781 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (552 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
LOC105514782Cys_knot domain-containing protein. (165 aa)
PLA2G4CPhospholipase A2 group IVC. (551 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
PTX3Pentraxin 3. (381 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (976 aa)
CDC42Cell division cycle 42. (191 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
SRCTyrosine-protein kinase. (458 aa)
GRB2Uncharacterized protein. (156 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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