STRINGSTRING
GYS1 GYS1 PRKAG2 PRKAG2 PPP1R3B PPP1R3B PPP1CA PPP1CA PYGL PYGL ENSCANP00000002557 ENSCANP00000002557 PCK2 PCK2 ENSCANP00000002629 ENSCANP00000002629 ENSCANP00000003071 ENSCANP00000003071 SLC27A4 SLC27A4 NFU1 NFU1 SOCS3 SOCS3 PRKCD PRKCD IRS1 IRS1 SLC27A2 SLC27A2 NFKBIA NFKBIA ACACB ACACB PTPN1 PTPN1 MLXIP MLXIP G6PC3 G6PC3 PRKCQ PRKCQ CPT1B CPT1B MLXIPL MLXIPL PRKAB2 PRKAB2 PTEN PTEN MAPK9 MAPK9 IKBKB IKBKB PTPRS PTPRS GSK3B GSK3B ENSCANP00000011220 ENSCANP00000011220 OGA OGA SLC27A1 SLC27A1 PRKAA1 PRKAA1 ENSCANP00000011808 ENSCANP00000011808 PRKCZ PRKCZ CREB5 CREB5 PPP1CB PPP1CB CREB1 CREB1 AGT AGT SLC27A3 SLC27A3 RPS6KB1 RPS6KB1 SREBF1 SREBF1 AKT1 AKT1 NOS3 NOS3 RPS6KA1 RPS6KA1 SLC27A5 SLC27A5 MLX MLX TRIB3 TRIB3 PIK3CA PIK3CA GFPT2 GFPT2 OGT OGT PCK1 PCK1 PPP1R3D PPP1R3D G6PC G6PC MAPK10 MAPK10 GYS2 GYS2 PPARGC1A PPARGC1A MAPK8 MAPK8 PRKAG3 PRKAG3 PIK3R1 PIK3R1 AKT2 AKT2 TNF TNF MTOR MTOR PRKCB PRKCB STAT3 STAT3 NR1H2 NR1H2 PRKAB1 PRKAB1 ENSCANP00000023062 ENSCANP00000023062 PDPK1 PDPK1 SLC27A6 SLC27A6 PPP1R3A PPP1R3A CRTC2 CRTC2 PPP1CC PPP1CC NFKB1 NFKB1 RPS6KA3 RPS6KA3 PPARA PPARA ENSCANP00000025796 ENSCANP00000025796 PPP1R3C PPP1R3C CREB3L4 CREB3L4 PRKAA2 PRKAA2 PYGB PYGB SLC2A4 SLC2A4 PPARGC1B PPARGC1B AKT3 AKT3 CREB3L1 CREB3L1 G6PC2 G6PC2 PIK3CB PIK3CB TNIK TNIK TPTE2 TPTE2 PRKCE PRKCE PIK3R2 PIK3R2 FOXO1 FOXO1 RPS6KA6 RPS6KA6 RELA RELA GFPT1 GFPT1 PTPN11 PTPN11 CD36 CD36 PTPRF PTPRF INS INS CREB3L2 CREB3L2 INSR INSR ENSCANP00000034934 ENSCANP00000034934 PIK3R3 PIK3R3 TNFRSF1A TNFRSF1A CREB3 CREB3 ENSCANP00000036145 ENSCANP00000036145 CPT1A CPT1A TBC1D4 TBC1D4 PIK3CD PIK3CD PRKAG1 PRKAG1 SLC2A1 SLC2A1 CREB3L3 CREB3L3 RPS6KA2 RPS6KA2 SLC2A2 SLC2A2 IL6 IL6 PTPA PTPA PYGM PYGM RPS6KB2 RPS6KB2 NR1H3 NR1H3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (620 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (544 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
ENSCANP00000002557Uncharacterized protein. (535 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
ENSCANP00000002629Uncharacterized protein. (87 aa)
ENSCANP00000003071SER_THR_PHOSPHATASE domain-containing protein. (146 aa)
SLC27A4Solute carrier family 27 member 4. (650 aa)
NFU1Nfu_N domain-containing protein. (185 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ACACBAcetyl-CoA carboxylase beta. (2438 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (465 aa)
MLXIPMLX interacting protein. (874 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
MLXIPLMLX interacting protein like. (852 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1797 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSCANP00000011220Uncharacterized protein. (277 aa)
OGAO-GlcNAcase. (805 aa)
SLC27A1Solute carrier family 27 member 1. (626 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSCANP00000011808NifU domain-containing protein. (81 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (392 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
SLC27A3Solute carrier family 27 member 3. (730 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1148 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
RPS6KA1Ribosomal protein S6 kinase. (728 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
MLXMAX dimerization protein MLX. (298 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (593 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (248 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ENSCANP00000023062Nfu_N domain-containing protein. (218 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
SLC27A6Solute carrier family 27 member 6. (619 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
PPARAPeroxisome proliferator activated receptor alpha. (448 aa)
ENSCANP00000025796Uncharacterized protein. (269 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (427 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPARGC1BPPARG coactivator 1 beta. (1025 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
TNIKTRAF2 and NCK interacting kinase. (1359 aa)
TPTE2Uncharacterized protein. (522 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PIK3R2Uncharacterized protein. (601 aa)
FOXO1Forkhead box O1. (655 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1914 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (461 aa)
INSRTyrosine-protein kinase receptor. (1388 aa)
ENSCANP00000034934SH2 domain-containing protein. (183 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ENSCANP00000036145Uncharacterized protein. (268 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
TBC1D4TBC1 domain family member 4. (1132 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (344 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (415 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (523 aa)
IL6Interleukin 6. (214 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (358 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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