STRINGSTRING
CASP3 CASP3 ENSCANP00000040251 ENSCANP00000040251 PLCB3 PLCB3 MAPK14 MAPK14 PIM1 PIM1 IL6 IL6 CDC42 CDC42 COL4A4 COL4A4 SMAD2 SMAD2 PIK3CD PIK3CD VEGFB VEGFB PLCB1 PLCB1 AGTR1 AGTR1 MFF MFF PIK3R3 PIK3R3 IL1A IL1A EGR1 EGR1 PLCB4 PLCB4 JAK2 JAK2 MAPK13 MAPK13 VCAM1 VCAM1 RELA RELA FOXO1 FOXO1 PIK3R2 PIK3R2 COL4A6 COL4A6 PRKCE PRKCE TGFB3 TGFB3 JUN JUN ICAM1 ICAM1 IL1B IL1B COL4A1 COL4A1 PIK3CB PIK3CB TGFBR1 TGFBR1 SERPINE1 SERPINE1 VEGFA VEGFA SMAD4 SMAD4 CXCL8 CXCL8 BAX BAX AKT3 AKT3 STAT1 STAT1 MAPK1 MAPK1 CDKN1B CDKN1B VEGFD VEGFD AGER AGER NFKB1 NFKB1 CSDE1 CSDE1 COL1A1 COL1A1 STAT3 STAT3 PRKCB PRKCB TNF TNF AKT2 AKT2 PIK3R1 PIK3R1 COL4A5 COL4A5 TGFB2 TGFB2 COL3A1 COL3A1 MAPK8 MAPK8 CCND1 CCND1 ENSCANP00000019829 ENSCANP00000019829 PLCD1 PLCD1 MAPK10 MAPK10 DIAPH1 DIAPH1 COL4A3 COL4A3 PIK3CA PIK3CA MAPK3 MAPK3 PLCD3 PLCD3 LOC105504658 LOC105504658 NOS3 NOS3 AKT1 AKT1 CDK4 CDK4 MAPK12 MAPK12 AGT AGT ENSCANP00000013076 ENSCANP00000013076 COL4A2 COL4A2 NOX3 NOX3 STAT5B STAT5B STAT5A STAT5A PLCG1 PLCG1 PRKCZ PRKCZ VEGFC VEGFC ENSCANP00000011118 ENSCANP00000011118 XK XK MAPK9 MAPK9 COL1A2 COL1A2 NFATC1 NFATC1 FN1 FN1 CYBB CYBB TGFB1 TGFB1 NOX4 NOX4 KRAS KRAS SELE SELE CCL2 CCL2 PLCE1 PLCE1 NOX1 NOX1 HRAS HRAS ENSCANP00000005072 ENSCANP00000005072 BCL2 BCL2 PRKCD PRKCD TGFBR2 TGFBR2 PLCD4 PLCD4 PLCB2 PLCB2 PRKCA PRKCA PLCG2 PLCG2 MAPK11 MAPK11 F3 F3 ERAS ERAS SMAD3 SMAD3 EDN1 EDN1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ENSCANP00000040251Uncharacterized protein; Belongs to the peptidase C14A family. (243 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (306 aa)
IL6Interleukin 6. (214 aa)
CDC42Cell division cycle 42. (191 aa)
COL4A4Collagen type IV alpha 4 chain. (1633 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
MFFMitochondrial fission factor. (342 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
FOXO1Forkhead box O1. (655 aa)
PIK3R2Uncharacterized protein. (601 aa)
COL4A6Collagen type IV alpha 6 chain. (1684 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
COL4A1Collagen type IV alpha 1 chain. (1627 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (337 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
CSDE1Uncharacterized protein. (844 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
PLCD1Phosphoinositide phospholipase C. (777 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
DIAPH1Diaphanous related formin 1. (1236 aa)
COL4A3Collagen type IV alpha 3 chain. (1646 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PLCD3Phosphoinositide phospholipase C. (758 aa)
LOC105504658Uncharacterized protein. (571 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
ENSCANP00000013076Uncharacterized protein. (164 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
NOX3NADPH oxidase 3. (568 aa)
STAT5BSignal transducer and activator of transcription. (756 aa)
STAT5ASignal transducer and activator of transcription. (789 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (392 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (459 aa)
ENSCANP00000011118Uncharacterized protein. (176 aa)
XKXK-related protein. (444 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
NFATC1Nuclear factor of activated T cells 1. (815 aa)
FN1Fibronectin 1. (2450 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
NOX4NADPH oxidase 4. (591 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SELESelectin E. (612 aa)
CCL2C-C motif chemokine. (99 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
NOX1NADPH oxidase 1. (522 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSCANP00000005072Uncharacterized protein. (168 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PLCD4Phosphoinositide phospholipase C. (801 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
F3Coagulation factor III, tissue factor. (296 aa)
ERASES cell expressed Ras. (233 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
EDN1Endothelin 1. (211 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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