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POU1F1 POU1F1 SOS1 SOS1 CACNA1C CACNA1C PIK3R2 PIK3R2 LOC105506399 LOC105506399 CEP152 CEP152 LOC105515982-2 LOC105515982-2 ATF4 ATF4 ADCY6 ADCY6 CREBBP CREBBP ENSCANP00000030604 ENSCANP00000030604 CRKL CRKL ADCY7 ADCY7 LOC105519388 LOC105519388 ADCY4 ADCY4 PIK3CB PIK3CB GHSR GHSR ITPR1 ITPR1 CREB3L1 CREB3L1 AKT3 AKT3 ADCY10 ADCY10 SHC3 SHC3 ADCY8 ADCY8 STAT1 STAT1 CREB3L4 CREB3L4 MAPK1 MAPK1 ADCY3 ADCY3 MAP3K1 MAP3K1 IGFALS IGFALS SHC2 SHC2 SHC1 SHC1 CSDE1 CSDE1 LOC105515980 LOC105515980 ADCY5 ADCY5 ITPR3 ITPR3 GNAI1 GNAI1 STAT3 STAT3 PRKCB PRKCB BCAR1 BCAR1 MAP2K4 MAP2K4 PTRHD1 PTRHD1 MTOR MTOR AKT2 AKT2 PIK3R1 PIK3R1 GHR GHR GNAS GNAS MAPK8 MAPK8 IGF1 IGF1 ENSCANP00000019829 ENSCANP00000019829 FOS FOS MAPK10 MAPK10 RAF1 RAF1 PRKACA PRKACA CRK CRK ADCY9 ADCY9 MAP2K3 MAP2K3 PIK3CA PIK3CA CACNA1F CACNA1F MAPK3 MAPK3 LOC105504658 LOC105504658 AKT1 AKT1 EP300 EP300 MAPK12 MAPK12 CREB1 CREB1 LOC105515982 LOC105515982 MAP2K2 MAP2K2 STAT5B STAT5B GNAI2 GNAI2 GNAI3 GNAI3 STAT5A STAT5A CREB5 CREB5 PLCG1 PLCG1 GHRL GHRL CACNA1S CACNA1S GSK3B GSK3B MAPK9 MAPK9 LOC105515984 LOC105515984 PRKCG PRKCG ADCY2 ADCY2 IGFBP3 IGFBP3 PRKACB PRKACB MAP2K6 MAP2K6 ENSCANP00000006830 ENSCANP00000006830 KRAS KRAS GNAQ GNAQ PLCB1 PLCB1 IRS1 IRS1 HRAS HRAS SOCS2 SOCS2 ATF2 ATF2 SHC4 SHC4 SSTR1 SSTR1 SOCS3 SOCS3 PLCB2 PLCB2 PRKCA PRKCA PLCG2 PLCG2 SSTR2 SSTR2 MAPK11 MAPK11 ERAS ERAS JUNB JUNB SSTR3 SSTR3 CACNA1D CACNA1D SOS2 SOS2 CREB3 CREB3 GRB2 GRB2 GHRH GHRH PLCB3 PLCB3 MAPK14 MAPK14 ENSCANP00000039354 ENSCANP00000039354 GHRHR GHRHR CREB3L3 CREB3L3 ADCY1 ADCY1 ITPR2 ITPR2 PTK2 PTK2 PIK3CD PIK3CD PIK3R3 PIK3R3 MAP2K1 MAP2K1 SST SST IRS4 IRS4 CREB3L2 CREB3L2 PLCB4 PLCB4 JAK2 JAK2 ATF6B ATF6B MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POU1F1POU domain protein. (317 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2134 aa)
PIK3R2Uncharacterized protein. (601 aa)
LOC105506399Uncharacterized protein. (246 aa)
CEP152Centrosomal protein 152. (1709 aa)
LOC105515982-2Uncharacterized protein. (139 aa)
ATF4Activating transcription factor 4. (351 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CREBBPCREB binding protein. (2117 aa)
ENSCANP00000030604Uncharacterized protein. (240 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1083 aa)
LOC105519388Uncharacterized protein. (118 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2697 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ADCY10Adenylate cyclase 10. (1588 aa)
SHC3SHC adaptor protein 3. (517 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (427 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1356 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (643 aa)
SHC2SHC adaptor protein 2. (381 aa)
SHC1SHC adaptor protein 1. (584 aa)
CSDE1Uncharacterized protein. (844 aa)
LOC105515980Uncharacterized protein. (233 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNAI1G protein subunit alpha i1. (354 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (915 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GHRGrowth hormone receptor. (645 aa)
GNASGNAS complex locus. (913 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (345 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1971 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC105504658Uncharacterized protein. (571 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
EP300E1A binding protein p300. (2409 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LOC105515982Uncharacterized protein. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
STAT5BSignal transducer and activator of transcription. (756 aa)
GNAI2G protein subunit alpha i2. (355 aa)
GNAI3G protein subunit alpha i3. (301 aa)
STAT5ASignal transducer and activator of transcription. (789 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
LOC105515984Uncharacterized protein. (217 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1014 aa)
IGFBP3Insulin like growth factor binding protein 3. (189 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNAQG protein subunit alpha q. (313 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SHC4SHC adaptor protein 4. (630 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
ERASES cell expressed Ras. (233 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (417 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
GRB2Uncharacterized protein. (156 aa)
GHRHGrowth hormone releasing hormone. (107 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (414 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (415 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (976 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SSTSomatostatin. (116 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (461 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
ATF6BActivating transcription factor 6 beta. (690 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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