50 items (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDYN	Prodynorphin. (254 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	GPSM1	G protein signaling modulator 1. (707 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (415 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (461 aa)
	ATF6B	Activating transcription factor 6 beta. (690 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (548 aa)
	LOC105506399	Uncharacterized protein. (246 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (733 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (427 aa)
	RGS9	Regulator of G protein signaling 9. (648 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1005 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (970 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	TH	Tyrosine hydroxylase. (529 aa)
	GRM2	Glutamate metabotropic receptor 2. (872 aa)
	ENSCANP00000020706	Protein kinase domain-containing protein. (281 aa)
	GNAS	GNAS complex locus. (913 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (834 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (345 aa)
	RGS11	Regulator of G protein signaling 11. (457 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	GNAI3	G protein subunit alpha i3. (301 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	MAOA	Amine oxidase. (527 aa)
	GRM3	Glutamate metabotropic receptor 3. (879 aa)
	DDC	Dopa decarboxylase. (480 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	MAOB	Amine oxidase. (520 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (674 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	GNAI1	ENSCANP00000023274	ENSCANP00000022697	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.686
ADCY5	GNAI2	ENSCANP00000023274	ENSCANP00000012671	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.843
ADCY5	GNAI3	ENSCANP00000023274	ENSCANP00000012552	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.686
ADCY5	GNAS	ENSCANP00000023274	ENSCANP00000020637	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.948
ADCY5	LOC105506399	ENSCANP00000023274	ENSCANP00000032034	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.818
ADCY5	PRKACA	ENSCANP00000023274	ENSCANP00000018127	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.896
ADCY5	PRKACB	ENSCANP00000023274	ENSCANP00000007296	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.918
ATF2	ATF4	ENSCANP00000004508	ENSCANP00000031219	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 4.	0.849
ATF2	ATF6B	ENSCANP00000004508	ENSCANP00000033976	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 6 beta.	0.855
ATF2	CREB1	ENSCANP00000004508	ENSCANP00000013309	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 1.	0.923
ATF2	CREB3	ENSCANP00000004508	ENSCANP00000035848	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3.	0.846
ATF2	CREB3L1	ENSCANP00000004508	ENSCANP00000028662	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 1.	0.818
ATF2	CREB3L2	ENSCANP00000004508	ENSCANP00000034425	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 2.	0.818
ATF2	CREB3L3	ENSCANP00000004508	ENSCANP00000037388	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 3.	0.821
ATF2	CREB3L4	ENSCANP00000004508	ENSCANP00000026737	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 4.	0.821
ATF2	CREB5	ENSCANP00000004508	ENSCANP00000012216	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.	0.958
ATF2	JUN	ENSCANP00000004508	ENSCANP00000031514	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.988
ATF2	PRKACA	ENSCANP00000004508	ENSCANP00000018127	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.844
ATF2	PRKACB	ENSCANP00000004508	ENSCANP00000007296	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.844
ATF4	ATF2	ENSCANP00000031219	ENSCANP00000004508	Activating transcription factor 4.	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	0.849