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IL1B IL1B MYD88 MYD88 HLA-DOB HLA-DOB IRAK4 IRAK4 TLR4 TLR4 LOC105513798 LOC105513798 PTPN6 PTPN6 STAT1 STAT1 MAPK1 MAPK1 TAB2 TAB2 IFNGR1 IFNGR1 NFKB1 NFKB1 FAM229A FAM229A CYBA CYBA LOC105513786 LOC105513786 ENSCANP00000022741 ENSCANP00000022741 IL4 IL4 PRKCB PRKCB TNF TNF HLA-DQA1 HLA-DQA1 HLA-DRB5 HLA-DRB5 TGFB2 TGFB2 ENSCANP00000020535 ENSCANP00000020535 LOC105513801 LOC105513801 NFKBIB NFKBIB IRAK1 IRAK1 FOS FOS ENSCANP00000018884 ENSCANP00000018884 HLA-DQB1 HLA-DQB1 ENSCANP00000018028 ENSCANP00000018028 TRAF6 TRAF6 TAB1 TAB1 ENSCANP00000016755 ENSCANP00000016755 ENSCANP00000016674 ENSCANP00000016674 LOC105514240 LOC105514240 JAK1 JAK1 LOC105502761 LOC105502761 MAPK3 MAPK3 ITGB2 ITGB2 ENSCANP00000014727 ENSCANP00000014727 IFNG IFNG HLA-DRA HLA-DRA MAPK12 MAPK12 PTGS2 PTGS2 ENSCANP00000039638 ENSCANP00000039638 MAPK14 MAPK14 IFNGR2 IFNGR2 HLA-DOA HLA-DOA EEF1A2 EEF1A2 FCGR2A FCGR2A IL12A IL12A IL10 IL10 IL1A IL1A LOC105526306 LOC105526306 HLA-DMA HLA-DMA NOS2 NOS2 JAK2 JAK2 IL12B IL12B ITGAM ITGAM MAPK13 MAPK13 LOC105519602 LOC105519602 NCF4 NCF4 RELA RELA NCF1 NCF1 TGFB3 TGFB3 LOC105501359 LOC105501359 JUN JUN CR1L CR1L FCGR1A FCGR1A MAPK11 MAPK11 NOXA1 NOXA1 ITGA4 ITGA4 LOC105507704 LOC105507704 LOC105501360 LOC105501360 TLR2 TLR2 MAP3K7 MAP3K7 ENSCANP00000005810 ENSCANP00000005810 ELK1 ELK1 LOC105515995 LOC105515995 NFKBIA NFKBIA LOC105501361 LOC105501361 NCF2 NCF2 TGFB1 TGFB1 EEF1A1 EEF1A1 CYBB CYBB CR1 CR1 C3 C3 ENSCANP00000039645 ENSCANP00000039645 ITGB1 ITGB1 ENSCANP00000012361 ENSCANP00000012361
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (438 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LOC105513798Ig-like domain-containing protein. (263 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
FAM229AUncharacterized protein. (78 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
LOC105513786Ig-like domain-containing protein. (266 aa)
ENSCANP00000022741Uncharacterized protein. (297 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa)
HLA-DRB5Major histocompatibility complex, class II, DR beta 5. (266 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSCANP00000020535Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (456 aa)
LOC105513801Ig-like domain-containing protein. (279 aa)
NFKBIBNFKB inhibitor beta. (321 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (648 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSCANP00000018884Tr-type G domain-containing protein. (113 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
ENSCANP00000018028Tr-type G domain-containing protein. (113 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSCANP00000016755Ig-like domain-containing protein. (142 aa)
ENSCANP00000016674Tr-type G domain-containing protein. (426 aa)
LOC105514240Ig-like domain-containing protein. (256 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
LOC105502761Ig-like domain-containing protein. (283 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ITGB2Integrin beta. (769 aa)
ENSCANP00000014727Ig-like domain-containing protein. (154 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ENSCANP00000039638Ig-like domain-containing protein. (130 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGR2Interferon gamma receptor 2. (231 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (364 aa)
FCGR2AUncharacterized protein. (316 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL10Interleukin 10. (178 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
LOC105526306Tr-type G domain-containing protein. (424 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1181 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
LOC105519602Ig-like domain-containing protein. (290 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC105501359Ig-like domain-containing protein. (281 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
CR1LComplement C3b/C4b receptor 1 like. (507 aa)
FCGR1AUncharacterized protein. (373 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
NOXA1NADPH oxidase activator 1. (424 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
LOC105507704ETS domain-containing protein. (403 aa)
LOC105501360Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
TLR2Toll-like receptor. (784 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSCANP00000005810Ig-like domain-containing protein. (222 aa)
ELK1ETS domain-containing protein. (428 aa)
LOC105515995Tr-type G domain-containing protein. (377 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
LOC105501361Ig-like domain-containing protein. (296 aa)
NCF2Neutrophil cytosolic factor 2. (498 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
EEF1A1Tr-type G domain-containing protein. (307 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
CR1Complement C3b/C4b receptor 1 (Knops blood group). (2038 aa)
C3Complement C3. (1508 aa)
ENSCANP00000039645Tr-type G domain-containing protein. (113 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSCANP00000012361Ig-like domain-containing protein. (111 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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