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| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa) |
| | ENSCANP00000002646 | Uncharacterized protein. (151 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (306 aa) |
| | FAS | Fas cell surface death receptor. (331 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (200 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (325 aa) |
| | AADACL2 | Arylacetamide deacetylase like 2. (401 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | CD247 | CD247 molecule. (163 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | CCL3L3 | C-C motif chemokine. (93 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (550 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (648 aa) |
| | GNAO1 | G protein subunit alpha o1. (354 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | GNAS | GNAS complex locus. (913 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | AKT2 | AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | TRAC | T cell receptor alpha constant. (110 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa) |
| | GNAI1 | G protein subunit alpha i1. (354 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (970 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (489 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (343 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (452 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (275 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (517 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | AADAC | Arylacetamide deacetylase. (399 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (275 aa) |
| | SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (337 aa) |
| | CD3D | CD3d molecule. (171 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (594 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa) |
| | C1QA | Complement C1q A chain. (245 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (438 aa) |
| | TLR9 | TIR domain-containing protein. (1033 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | CALR | Calreticulin. (417 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | GNA11 | G protein subunit alpha 11. (353 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa) |
| | LOC105506399 | Uncharacterized protein. (246 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | PIK3R2 | Uncharacterized protein. (601 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (548 aa) |
| | C1QC | Complement C1q C chain. (245 aa) |
| | C1QB | Complement C1q B chain. (253 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (491 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | CD3G | CD3g molecule. (181 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1181 aa) |
| | CCL5 | C-C motif chemokine. (91 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | KNG1 | Kininogen 1. (644 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | IL10 | Interleukin 10. (178 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | CD3E | CD3e molecule. (198 aa) |
| | CCL3 | C-C motif chemokine. (92 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (231 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (976 aa) |
| | GNA15 | G protein subunit alpha 15. (374 aa) |
| | IL6 | Interleukin 6. (214 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | GNAI3 | G protein subunit alpha i3. (301 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | ACE | Angiotensin-converting enzyme. (1223 aa) |
| | C3 | Complement C3. (1508 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (399 aa) |
| | LOC105510963 | Serine/threonine-protein phosphatase. (291 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | ENSCANP00000006830 | Protein kinase domain-containing protein. (373 aa) |
| | GNAQ | G protein subunit alpha q. (313 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | PGBD4 | PiggyBac transposable element derived 4. (585 aa) |
| | GNA14 | Uncharacterized protein. (157 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | TRAV22 | T cell receptor alpha variable 22. (147 aa) |
