STRINGSTRING
PPP1R14B PPP1R14B CASP3 CASP3 ENSCANP00000000466 ENSCANP00000000466 LOC105521896 LOC105521896 BCL2L1 BCL2L1 HSPA8 HSPA8 PIK3R6 PIK3R6 LOC105523208 LOC105523208 PIK3CG PIK3CG MAPK11 MAPK11 HSPA6 HSPA6 ENSCANP00000002453 ENSCANP00000002453 LOC105516629 LOC105516629 CCR5 CCR5 ENSCANP00000003898 ENSCANP00000003898 LOC105501360 LOC105501360 TLR2 TLR2 LAMB2 LAMB2 CD40 CD40 BIRC2 BIRC2 BIRC7 BIRC7 BCL2 BCL2 BAD BAD MAP3K7 MAP3K7 CHUK CHUK ENSCANP00000005565 ENSCANP00000005565 ENSCANP00000006223 ENSCANP00000006223 MAP2K6 MAP2K6 LOC105521523 LOC105521523 NFKBIA NFKBIA LOC105501361 LOC105501361 LDLR LDLR CIITA CIITA CASP9 CASP9 TGFB1 TGFB1 LAMA1 LAMA1 MAPK9 MAPK9 IKBKB IKBKB LAMA5 LAMA5 CASP8 CASP8 GNAI3 GNAI3 LAMA3 LAMA3 GNAI2 GNAI2 ITGB1 ITGB1 ITGA6 ITGA6 MAPK12 MAPK12 HLA-DRA HLA-DRA IFNG IFNG AKT1 AKT1 LOC105500830 LOC105500830 MAPK3 MAPK3 PIK3R5 PIK3R5 LOC105502761 LOC105502761 JAK1 JAK1 LOC105514240 LOC105514240 ENSCANP00000016286 ENSCANP00000016286 MAP2K3 MAP2K3 LAMB3 LAMB3 TAB1 TAB1 TRAF6 TRAF6 HLA-DQB1 HLA-DQB1 MAPK10 MAPK10 C7orf31 C7orf31 IRAK1 IRAK1 GNAO1 GNAO1 LY96 LY96 TYK2 TYK2 NFKBIB NFKBIB LAMC3 LAMC3 LOC105513801 LOC105513801 MAPK8 MAPK8 TGFB2 TGFB2 ENSCANP00000020790 ENSCANP00000020790 ALOX5 ALOX5 HLA-DRB5 HLA-DRB5 LAMA2 LAMA2 LOC105503927 LOC105503927 HLA-DQA1 HLA-DQA1 AKT2 AKT2 TNF TNF LAMA4 LAMA4 STAT3 STAT3 GNAI1 GNAI1 LOC105513786 LOC105513786 IL10RA IL10RA PDPK1 PDPK1 NFKB1 NFKB1 BIRC3 BIRC3 IFNGR1 IFNGR1 TAB2 TAB2 MAPK1 MAPK1 STAT1 STAT1 LOC105513798 LOC105513798 AKT3 AKT3 LAMB4 LAMB4 TLR4 TLR4 LAMC2 LAMC2 HSPA1L HSPA1L IRAK4 IRAK4 LAMB1 LAMB1 ENSCANP00000030335 ENSCANP00000030335 HLA-DOB HLA-DOB MYD88 MYD88 LOC105501359 LOC105501359 TGFB3 TGFB3 CYCS CYCS RELA RELA MAPK13 MAPK13 ENSCANP00000033724 ENSCANP00000033724 IL12B IL12B JAK2 JAK2 CD40LG CD40LG NOS2 NOS2 HLA-DMA HLA-DMA IL10RB IL10RB TNFRSF1A TNFRSF1A IL10 IL10 IKBKG IKBKG HSPA2 HSPA2 IL12A IL12A HLA-DOA HLA-DOA IFNGR2 IFNGR2 PPIF PPIF ENSCANP00000038640 ENSCANP00000038640 XIAP XIAP MAPK14 MAPK14 ENSCANP00000040251 ENSCANP00000040251
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (132 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ENSCANP00000000466Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105521896Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BCL2L1BCL2 like 1. (233 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (709 aa)
LOC105523208Uncharacterized protein. (380 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (576 aa)
ENSCANP00000002453Uncharacterized protein; Belongs to the heat shock protein 70 family. (529 aa)
LOC105516629Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
ENSCANP00000003898Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105501360Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
TLR2Toll-like receptor. (784 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
CD40CD40 molecule. (278 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSCANP00000005565Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
ENSCANP00000006223Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC105521523Uncharacterized protein; Belongs to the heat shock protein 70 family. (599 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
LOC105501361Ig-like domain-containing protein. (296 aa)
LDLRLow density lipoprotein receptor. (777 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
LAMA1Laminin subunit alpha 1. (3054 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LAMA5Laminin subunit alpha 5. (3457 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
GNAI3G protein subunit alpha i3. (301 aa)
LAMA3Laminin subunit alpha 3. (3235 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1070 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105500830Uncharacterized protein; Belongs to the heat shock protein 70 family. (608 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
LOC105502761Ig-like domain-containing protein. (283 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
LOC105514240Ig-like domain-containing protein. (256 aa)
ENSCANP00000016286Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (86 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (648 aa)
GNAO1G protein subunit alpha o1. (354 aa)
LY96Lymphocyte antigen 96. (160 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
NFKBIBNFKB inhibitor beta. (321 aa)
LAMC3Laminin subunit gamma 3. (1410 aa)
LOC105513801Ig-like domain-containing protein. (279 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSCANP00000020790Uncharacterized protein. (84 aa)
ALOX5Arachidonate 5-lipoxygenase. (508 aa)
HLA-DRB5Major histocompatibility complex, class II, DR beta 5. (266 aa)
LAMA2Laminin subunit alpha 2. (3066 aa)
LOC105503927Uncharacterized protein; Belongs to the heat shock protein 70 family. (592 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LAMA4Laminin subunit alpha 4. (1816 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
GNAI1G protein subunit alpha i1. (354 aa)
LOC105513786Ig-like domain-containing protein. (266 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
LOC105513798Ig-like domain-containing protein. (263 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LAMB4Laminin subunit beta 4. (1684 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (438 aa)
LAMB1Laminin subunit beta 1. (1796 aa)
ENSCANP00000030335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (97 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
LOC105501359Ig-like domain-containing protein. (281 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
ENSCANP00000033724Uncharacterized protein. (794 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1181 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IL10Interleukin 10. (178 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
IFNGR2Interferon gamma receptor 2. (231 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (159 aa)
ENSCANP00000038640Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCANP00000040251Uncharacterized protein; Belongs to the peptidase C14A family. (243 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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