STRINGSTRING
ENSCANP00000000624 ENSCANP00000000624 RPS6KB2 RPS6KB2 GRB2 GRB2 ENSCANP00000040251 ENSCANP00000040251 ENSCANP00000039354 ENSCANP00000039354 AREG AREG ENSCANP00000038640 ENSCANP00000038640 RALB RALB PPP1R14B PPP1R14B EPGN EPGN SMAD2 SMAD2 PIK3CD PIK3CD GADD45A GADD45A MSH3 MSH3 BIRC5 BIRC5 SOS2 SOS2 BRAF BRAF DCC DCC PIK3R3 PIK3R3 MAP2K1 MAP2K1 TCF7L1 TCF7L1 POLK POLK PMAIP1 PMAIP1 DDB2 DDB2 SOS1 SOS1 PIK3R2 PIK3R2 CYCS CYCS TGFB3 TGFB3 JUN JUN LOC105514391 LOC105514391 ENSCANP00000031005 ENSCANP00000031005 ENSCANP00000030335 ENSCANP00000030335 APPL1 APPL1 PIK3CB PIK3CB MYC MYC TGFBR1 TGFBR1 SMAD4 SMAD4 TP53 TP53 BAX BAX AKT3 AKT3 TCF7 TCF7 MAPK1 MAPK1 CDKN1A CDKN1A RALGDS RALGDS CSDE1 CSDE1 AXIN1 AXIN1 GADD45G GADD45G ARAF ARAF MTOR MTOR AKT2 AKT2 PIK3R1 PIK3R1 BAK1 BAK1 ENSCANP00000020790 ENSCANP00000020790 TGFB2 TGFB2 EREG EREG MAPK8 MAPK8 CCND1 CCND1 ENSCANP00000019829 ENSCANP00000019829 APC2 APC2 FOS FOS EGF EGF C7orf31 C7orf31 MAPK10 MAPK10 RAF1 RAF1 RALA RALA EGFR EGFR TCF7L2 TCF7L2 PIK3CA PIK3CA ENSCANP00000016286 ENSCANP00000016286 MAPK3 MAPK3 LOC105504658 LOC105504658 RAC2 RAC2 AKT1 AKT1 LOC105521593 LOC105521593 RPS6KB1 RPS6KB1 MAP2K2 MAP2K2 GADD45B GADD45B CTNNB1 CTNNB1 LOC105514932 LOC105514932 GSK3B GSK3B MAPK9 MAPK9 BCL2L11 BCL2L11 ENSCANP00000009565 ENSCANP00000009565 RHOC RHOC TGFB1 TGFB1 CASP9 CASP9 RHOA RHOA MSH2 MSH2 APC APC KRAS KRAS TGFA TGFA ENSCANP00000006223 ENSCANP00000006223 ENSCANP00000005565 ENSCANP00000005565 HRAS HRAS BAD BAD BCL2 BCL2 TGFBR2 TGFBR2 ENSCANP00000003898 ENSCANP00000003898 MSH6 MSH6 MLH1 MLH1 LOC105516629 LOC105516629 ERAS ERAS AXIN2 AXIN2 SMAD3 SMAD3 LOC105521896 LOC105521896 RAC1 RAC1 LEF1 LEF1 ENSCANP00000000466 ENSCANP00000000466 CASP3 CASP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCANP00000000624Ras-GEF domain-containing protein. (399 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
GRB2Uncharacterized protein. (156 aa)
ENSCANP00000040251Uncharacterized protein; Belongs to the peptidase C14A family. (243 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
AREGAmphiregulin. (275 aa)
ENSCANP00000038640Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
RALBRAS like proto-oncogene B. (212 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (132 aa)
EPGNEpithelial mitogen. (154 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1129 aa)
BIRC5Baculoviral IAP repeat containing 5. (147 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (747 aa)
DCCDCC netrin 1 receptor. (1447 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TCF7L1Transcription factor 7 like 1. (512 aa)
POLKDNA polymerase kappa. (869 aa)
PMAIP1Uncharacterized protein. (124 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
PIK3R2Uncharacterized protein. (601 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
LOC105514391Uncharacterized protein. (190 aa)
ENSCANP00000031005Uncharacterized protein. (101 aa)
ENSCANP00000030335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (97 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (658 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TCF7Transcription factor 7. (398 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RALGDSUncharacterized protein. (839 aa)
CSDE1Uncharacterized protein. (844 aa)
AXIN1Axin 1. (859 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (93 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (587 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSCANP00000020790Uncharacterized protein. (84 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EREGEpiregulin. (169 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
APC2APC regulator of WNT signaling pathway 2. (1681 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RALARAS like proto-oncogene A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCANP00000016286Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (86 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC105504658Uncharacterized protein. (571 aa)
RAC2Rac family small GTPase 2. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105521593Uncharacterized protein. (181 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC105514932Ras-GEF domain-containing protein. (570 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSCANP00000009565Uncharacterized protein. (651 aa)
RHOCRas homolog family member C. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
RHOARas homolog family member A. (193 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (904 aa)
APCAPC regulator of WNT signaling pathway. (2843 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSCANP00000006223Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCANP00000005565Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSCANP00000003898Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1332 aa)
MLH1MutL homolog 1. (743 aa)
LOC105516629Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ERASES cell expressed Ras. (233 aa)
AXIN2Axin 2. (843 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC105521896Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RAC1Uncharacterized protein. (205 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ENSCANP00000000466Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (18%) [HD]