STRINGSTRING
WNT10A WNT10A LEF1 LEF1 AXIN2 AXIN2 GLI1 GLI1 DVL3 DVL3 GLI2 GLI2 GADD45A GADD45A FZD3 FZD3 WNT16 WNT16 TCF7L1 TCF7L1 POLK POLK WNT2B WNT2B WNT5A WNT5A DDB2 DDB2 SHH SHH HHIP HHIP FZD7 FZD7 TP53 TP53 FZD5 FZD5 WNT9A WNT9A DVL2 DVL2 WNT3A WNT3A BAX BAX FZD8 FZD8 TCF7 TCF7 FZD2 FZD2 WNT4 WNT4 KIF7 KIF7 CDKN1A CDKN1A AXIN1 AXIN1 GADD45G GADD45G BAK1 BAK1 WNT6 WNT6 APC2 APC2 WNT7A WNT7A PTCH2 PTCH2 FZD6 FZD6 WNT8B WNT8B WNT2 WNT2 TCF7L2 TCF7L2 GLI3 GLI3 WNT5B WNT5B SUFU SUFU WNT8A WNT8A WNT10B WNT10B BMP4 BMP4 BMP2 BMP2 GADD45B GADD45B WNT11 WNT11 CTNNB1 CTNNB1 PTCH1 PTCH1 GSK3B GSK3B WNT3 WNT3 KIF27 KIF27 WNT1 WNT1 FZD4 FZD4 APC APC SMO SMO WNT7B WNT7B DVL1 DVL1 WNT9B WNT9B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
AXIN2Axin 2. (843 aa)
GLI1GLI family zinc finger 1. (1065 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
GLI2GLI family zinc finger 2. (1585 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TCF7L1Transcription factor 7 like 1. (512 aa)
POLKDNA polymerase kappa. (869 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
HHIPHedgehog interacting protein. (700 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (488 aa)
TCF7Transcription factor 7. (398 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1297 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AXIN1Axin 1. (859 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (93 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
APC2APC regulator of WNT signaling pathway 2. (1681 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PTCH2Patched 2. (1207 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
GLI3GLI family zinc finger 3. (1580 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
CTNNB1Catenin beta 1. (781 aa)
PTCH1Patched 1. (1449 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
APCAPC regulator of WNT signaling pathway. (2843 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
DVL1Dishevelled segment polarity protein 1. (694 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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