STRINGSTRING
GADD45A GADD45A BRAF BRAF PIK3R3 PIK3R3 MAP2K1 MAP2K1 CDK6 CDK6 PDGFC PDGFC POLK POLK FGF2 FGF2 HGF HGF DDB2 DDB2 PIK3R2 PIK3R2 TPTE2 TPTE2 FGF7 FGF7 E2F1 E2F1 PIK3CB PIK3CB TP53 TP53 BAX BAX AKT3 AKT3 GALK2 GALK2 E2F2 E2F2 MAPK1 MAPK1 CDKN1A CDKN1A PDGFD PDGFD CSDE1 CSDE1 MET MET GADD45G GADD45G ARAF ARAF CDH1 CDH1 AKT2 AKT2 PIK3R1 PIK3R1 BAK1 BAK1 ENSCANP00000020790 ENSCANP00000020790 CCND1 CCND1 IGF1 IGF1 FGF19 FGF19 ENSCANP00000019829 ENSCANP00000019829 PDGFRA PDGFRA ERAS ERAS FGF1 FGF1 ENSCANP00000002629 ENSCANP00000002629 BAD BAD FGF21 FGF21 HRAS HRAS PDGFA PDGFA CDKN2A CDKN2A KRAS KRAS FGF23 FGF23 FGF10 FGF10 FGF22 FGF22 PDGFRB PDGFRB FGF8 FGF8 ENSCANP00000009565 ENSCANP00000009565 PTEN PTEN FGF20 FGF20 FGF5 FGF5 FGF6 FGF6 FGF17 FGF17 GADD45B GADD45B MAP2K2 MAP2K2 IGF1R IGF1R CDK4 CDK4 AKT1 AKT1 MITF MITF LOC105504658 LOC105504658 MAPK3 MAPK3 FGF16 FGF16 PDGFB PDGFB PIK3CA PIK3CA EGFR EGFR RAF1 RAF1 FGF9 FGF9 EGF EGF ENSCANP00000039354 ENSCANP00000039354 E2F3 E2F3 FGF18 FGF18 FGF3 FGF3 PPP1R14B PPP1R14B FGFR1 FGFR1 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (747 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
POLKDNA polymerase kappa. (869 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R2Uncharacterized protein. (601 aa)
TPTE2Uncharacterized protein. (522 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
E2F1E2F transcription factor 1. (436 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GALK2Galactokinase 2. (458 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
CSDE1Uncharacterized protein. (844 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (93 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (587 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (770 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSCANP00000020790Uncharacterized protein. (84 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
IGF1Insulin like growth factor 1. (208 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (173 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ERASES cell expressed Ras. (233 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ENSCANP00000002629Uncharacterized protein. (87 aa)
BADBCL2 associated agonist of cell death. (167 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (307 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (131 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
ENSCANP00000009565Uncharacterized protein. (651 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
LOC105504658Uncharacterized protein. (571 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
E2F3E2F transcription factor 3. (381 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (637 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (132 aa)
FGFR1Fibroblast growth factor receptor. (815 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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