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| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (476 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (198 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | SHC3 | SHC adaptor protein 3. (517 aa) |
| | ENSCANP00000027012 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (435 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (343 aa) |
| | GAB4 | GRB2 associated binding protein family member 4. (436 aa) |
| | ENSCANP00000025796 | Uncharacterized protein. (269 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (970 aa) |
| | SHC2 | SHC adaptor protein 2. (381 aa) |
| | SHC1 | SHC adaptor protein 1. (584 aa) |
| | CSDE1 | Uncharacterized protein. (844 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (93 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (587 aa) |
| | AKT2 | AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | ENSCANP00000020790 | Uncharacterized protein. (84 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | ENSCANP00000019829 | Uncharacterized protein. (98 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (455 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | LOC105504658 | Uncharacterized protein. (571 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa) |
| | GAB2 | GRB2 associated binding protein 2. (655 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1127 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa) |
| | STAT5B | Signal transducer and activator of transcription. (756 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (176 aa) |
| | STAT5A | Signal transducer and activator of transcription. (789 aa) |
| | LOC105516286 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (449 aa) |
| | ENSCANP00000011220 | Uncharacterized protein. (277 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ENSCANP00000009565 | Uncharacterized protein. (651 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (442 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa) |
| | MECOM | MDS1 and EVI1 complex locus. (1230 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CDKN2A | Cyclin dependent kinase inhibitor 2A. (159 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | LOC105527037 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (459 aa) |
| | ENSCANP00000002557 | Uncharacterized protein. (535 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | GRB2 | Uncharacterized protein. (156 aa) |
| | ENSCANP00000039354 | Protein kinase domain-containing protein. (353 aa) |
| | CBL | Cbl proto-oncogene. (888 aa) |
| | E2F3 | E2F transcription factor 3. (381 aa) |
| | PPP1R14B | Protein phosphatase 1 regulatory inhibitor subunit 14B. (132 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | CTBP2 | C-terminal binding protein 2. (985 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | ENSCANP00000036145 | Uncharacterized protein. (268 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (747 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | ENSCANP00000034934 | SH2 domain-containing protein. (183 aa) |
| | POLK | DNA polymerase kappa. (869 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (548 aa) |
| | PIK3R2 | Uncharacterized protein. (601 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CEP152 | Centrosomal protein 152. (1709 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
