STRINGSTRING
PIK3R1 PIK3R1 AKT2 AKT2 MTOR MTOR ARAF ARAF STAT3 STAT3 CSDE1 CSDE1 MPO MPO NFKB1 NFKB1 MAPK1 MAPK1 TCF7 TCF7 AKT3 AKT3 CD14 CD14 MYC MYC CCNA2 CCNA2 PIK3CB PIK3CB PER2 PER2 PIK3R2 PIK3R2 RELA RELA SOS1 SOS1 CEBPE CEBPE ITGAM ITGAM TCF7L1 TCF7L1 MAP2K1 MAP2K1 PIK3R3 PIK3R3 FLT3 FLT3 BRAF BRAF KIT KIT SOS2 SOS2 IKBKG IKBKG PIK3CD PIK3CD PPP1R14B PPP1R14B BCL2A1 BCL2A1 SPI1 SPI1 PIM1 PIM1 ENSCANP00000039354 ENSCANP00000039354 JUP JUP GRB2 GRB2 RPS6KB2 RPS6KB2 DUSP6 DUSP6 LEF1 LEF1 FCGR1A FCGR1A ERAS ERAS BAD BAD HRAS HRAS CHUK CHUK EIF4EBP1 EIF4EBP1 KRAS KRAS PML PML ZBTB16 ZBTB16 ENSCANP00000009565 ENSCANP00000009565 IKBKB IKBKB IL3 IL3 RUNX1T1 RUNX1T1 CSF2 CSF2 STAT5A STAT5A PIM2 PIM2 STAT5B STAT5B MAP2K2 MAP2K2 RPS6KB1 RPS6KB1 AKT1 AKT1 LOC105504658 LOC105504658 MAPK3 MAPK3 RUNX1 RUNX1 PIK3CA PIK3CA RARA RARA CSF1R CSF1R TCF7L2 TCF7L2 RAF1 RAF1 PPARD PPARD CCNA1 CCNA1 ENSCANP00000019829 ENSCANP00000019829 CCND1 CCND1 ENSCANP00000020790 ENSCANP00000020790
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (587 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
CSDE1Uncharacterized protein. (844 aa)
MPOMyeloperoxidase. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
TCF7Transcription factor 7. (398 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
PER2Period circadian regulator 2. (1254 aa)
PIK3R2Uncharacterized protein. (601 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
TCF7L1Transcription factor 7 like 1. (512 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (995 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (747 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (369 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (132 aa)
BCL2A1BCL2 related protein A1. (175 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (306 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
JUPJunction plakoglobin. (746 aa)
GRB2Uncharacterized protein. (156 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
FCGR1AUncharacterized protein. (373 aa)
ERASES cell expressed Ras. (233 aa)
BADBCL2 associated agonist of cell death. (167 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PMLPromyelocytic leukemia. (882 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ENSCANP00000009565Uncharacterized protein. (651 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (662 aa)
CSF2Colony stimulating factor 2. (144 aa)
STAT5ASignal transducer and activator of transcription. (789 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
STAT5BSignal transducer and activator of transcription. (756 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105504658Uncharacterized protein. (571 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (455 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RARARetinoic acid receptor alpha. (478 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSCANP00000020790Uncharacterized protein. (84 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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