STRINGSTRING
RPS6KB2 RPS6KB2 GRB2 GRB2 ENSCANP00000039354 ENSCANP00000039354 WASF3 WASF3 SLC44A3 SLC44A3 CHKA CHKA PIK3CD PIK3CD LOC105511976 LOC105511976 ENSCANP00000036423 ENSCANP00000036423 SOS2 SOS2 PLA2G4C PLA2G4C PIP5K1B PIP5K1B PIK3R3 PIK3R3 TSC2 TSC2 MAP2K1 MAP2K1 ENSCANP00000034867 ENSCANP00000034867 RHEB RHEB PLA2G4B PLA2G4B PDGFC PDGFC ENSCANP00000033084 ENSCANP00000033084 SOS1 SOS1 LYPLA1 LYPLA1 PIK3R2 PIK3R2 PLA2G4F PLA2G4F ENSCANP00000032256 ENSCANP00000032256 JUN JUN LOC105514391 LOC105514391 SLC44A2 SLC44A2 PCYT1B PCYT1B PIK3CB PIK3CB DGKI DGKI SLC44A1 SLC44A1 HIF1A HIF1A AKT3 AKT3 SLC44A4 SLC44A4 SP1 SP1 MAPK1 MAPK1 PIP5K1A PIP5K1A DGKH DGKH RALGDS RALGDS SLC44A5 SLC44A5 PCYT1A PCYT1A PDGFD PDGFD CSDE1 CSDE1 PDPK1 PDPK1 JMJD7 JMJD7 PRKCB PRKCB DGKD DGKD MTOR MTOR AKT2 AKT2 PIK3R1 PIK3R1 PLPP2 PLPP2 WASF2 WASF2 MAPK8 MAPK8 WASF1 WASF1 ENSCANP00000019829 ENSCANP00000019829 PLPP1 PLPP1 SLC22A3 SLC22A3 PLA2G4A PLA2G4A FOS FOS EGF EGF MAPK10 MAPK10 SLC22A2 SLC22A2 DGKQ DGKQ RAF1 RAF1 EGFR EGFR ENSCANP00000017622 ENSCANP00000017622 PIK3CA PIK3CA PLA2G4E PLA2G4E PDGFB PDGFB MAPK3 MAPK3 LOC105504658 LOC105504658 RAC2 RAC2 AKT1 AKT1 LOC105521593 LOC105521593 RPS6KB1 RPS6KB1 PLD1 PLD1 SLC22A5 SLC22A5 MAP2K2 MAP2K2 PLCG1 PLCG1 DGKE DGKE DGKA DGKA LOC105514932 LOC105514932 MAPK9 MAPK9 PRKCG PRKCG PDGFRB PDGFRB SLC22A1 SLC22A1 RHEBL1 RHEBL1 KRAS KRAS EIF4EBP1 EIF4EBP1 ENSCANP00000005843 ENSCANP00000005843 PDGFA PDGFA DGKK DGKK DGKB DGKB HRAS HRAS TSC1 TSC1 WAS WAS PLD2 PLD2 SLC5A7 SLC5A7 PLA2G4D PLA2G4D PRKCA PRKCA DGKZ DGKZ DGKG DGKG PIP5K1C PIP5K1C ERAS ERAS CHPT1 CHPT1 PDGFRA PDGFRA ENSCANP00000000624 ENSCANP00000000624 RAC1 RAC1 PLPP3 PLPP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
GRB2Uncharacterized protein. (156 aa)
ENSCANP00000039354Protein kinase domain-containing protein. (353 aa)
WASF3WASP family member 3. (502 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (653 aa)
CHKACholine kinase alpha. (424 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
LOC105511976Choline kinase beta. (344 aa)
ENSCANP00000036423PIPK domain-containing protein. (479 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PLA2G4CPhospholipase A2 group IVC. (551 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
TSC2TSC complex subunit 2. (1656 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSCANP00000034867PIPK domain-containing protein. (557 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
PLA2G4BPhospholipase A2. (781 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ENSCANP00000033084Abhydrolase_2 domain-containing protein. (145 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1310 aa)
LYPLA1Lysophospholipase 1. (141 aa)
PIK3R2Uncharacterized protein. (601 aa)
PLA2G4FPhospholipase A2. (791 aa)
ENSCANP00000032256Uncharacterized protein. (199 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
LOC105514391Uncharacterized protein. (190 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (710 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
DGKIDiacylglycerol kinase. (972 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (658 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (710 aa)
SP1Sp1 transcription factor. (718 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
DGKHDiacylglycerol kinase eta. (780 aa)
RALGDSUncharacterized protein. (839 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (719 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (342 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
CSDE1Uncharacterized protein. (844 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
DGKDDiacylglycerol kinase. (1177 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (478 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PLPP2Phospholipid phosphatase 2. (191 aa)
WASF2WASP family member 2. (498 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
WASF1WASP family member 1. (559 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
PLPP1Phospholipid phosphatase 1. (284 aa)
SLC22A3Solute carrier family 22 member 3. (492 aa)
PLA2G4APhospholipase A2. (749 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
SLC22A2Solute carrier family 22 member 2. (555 aa)
DGKQDiacylglycerol kinase. (892 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
ENSCANP00000017622Abhydrolase_2 domain-containing protein. (200 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLA2G4EPhospholipase A2. (869 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC105504658Uncharacterized protein. (571 aa)
RAC2Rac family small GTPase 2. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC105521593Uncharacterized protein. (181 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PLD1Phospholipase. (971 aa)
SLC22A5Solute carrier family 22 member 5. (581 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
DGKEDiacylglycerol kinase. (567 aa)
DGKADiacylglycerol kinase. (760 aa)
LOC105514932Ras-GEF domain-containing protein. (570 aa)
MAPK9Mitogen-activated protein kinase. (399 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
RHEBL1RHEB like 1. (183 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
ENSCANP00000005843PH domain-containing protein. (89 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (307 aa)
DGKKDiacylglycerol kinase. (1270 aa)
DGKBDiacylglycerol kinase. (804 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TSC1TSC complex subunit 1. (1164 aa)
WASWASP actin nucleation promoting factor. (504 aa)
PLD2Phospholipase. (859 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
PLA2G4DPhospholipase A2. (794 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
DGKZDiacylglycerol kinase. (1118 aa)
DGKGDiacylglycerol kinase. (791 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (665 aa)
ERASES cell expressed Ras. (233 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (331 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ENSCANP00000000624Ras-GEF domain-containing protein. (399 aa)
RAC1Uncharacterized protein. (205 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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