STRINGSTRING
pat pat KTR10934.1 KTR10934.1 KTR10913.1 KTR10913.1 trpD trpD KTR10151.1 KTR10151.1 KTR09791.1 KTR09791.1 KTR09683.1 KTR09683.1 KTR09141.1 KTR09141.1 KTR08957.1 KTR08957.1 aroQ aroQ hisH hisH hisB hisB hisC hisC dapF dapF dapA dapA KTR08658.1 KTR08658.1 aspA aspA trpF trpF KTR08366.1 KTR08366.1 KTR08368.1 KTR08368.1 KTR08152.1 KTR08152.1 thrB thrB KTR08081.1 KTR08081.1 KTR08082.1 KTR08082.1 lysA lysA KTR07969.1 KTR07969.1 KTR07234.1 KTR07234.1 hisD hisD KTR07128.1 KTR07128.1 KTR06483.1 KTR06483.1 KTR06484.1 KTR06484.1 KTR06430.1 KTR06430.1 hisD-2 hisD-2 KTR06076.1 KTR06076.1 KTR05879.1 KTR05879.1 KTR05884.1 KTR05884.1 asd asd KTR05643.1 KTR05643.1 KTR05227.1 KTR05227.1 KTR04851.1 KTR04851.1 argH argH argG argG KTR04854.1 KTR04854.1 KTR04865.1 KTR04865.1 argB argB argJ argJ argC argC KTR04712.1 KTR04712.1 KTR04645.1 KTR04645.1 dapD dapD KTR04648.1 KTR04648.1 KTR04426.1 KTR04426.1 metXA metXA KTR04367.1 KTR04367.1 KTR04000.1 KTR04000.1 KTR03818.1 KTR03818.1 trpE trpE hisI hisI hisF hisF hisG hisG hisE hisE metK metK aroB aroB aroK aroK aroC aroC ahcY ahcY KTR02589.1 KTR02589.1 KTR02590.1 KTR02590.1 KTR02418.1 KTR02418.1 aroA-2 aroA-2 KTR02332.1 KTR02332.1 trpA trpA trpB trpB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
KTR10934.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
KTR10913.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa)
KTR10151.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
KTR09791.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
KTR09683.1Inositol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
KTR09141.1Para-aminobenzoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
KTR08957.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (211 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
hisCAspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (296 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (325 aa)
KTR08658.1Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (248 aa)
aspAAspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (490 aa)
trpFPhosphoribosylanthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (207 aa)
KTR08366.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
KTR08368.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
KTR08152.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (308 aa)
KTR08081.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (359 aa)
KTR08082.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (494 aa)
KTR07969.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
KTR07234.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (446 aa)
KTR07128.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
KTR06483.1Catalyzes the conversion of shikimate to 3-dehydroshikimate; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
KTR06484.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (461 aa)
KTR06430.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
KTR06076.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (461 aa)
KTR05879.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
KTR05884.1Inositol-phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (350 aa)
KTR05643.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (421 aa)
KTR05227.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
KTR04851.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA glycosylase MPG family. (226 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
argGArgininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (398 aa)
KTR04854.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (317 aa)
KTR04865.1Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (344 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (372 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (365 aa)
KTR04712.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
KTR04645.1N-succinyldiaminopimelate aminotransferase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (321 aa)
KTR04648.1Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
KTR04426.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
metXAHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (399 aa)
KTR04367.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
KTR04000.1Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
KTR03818.1Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
trpEAnthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (509 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (127 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (279 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (407 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (360 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (406 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (492 aa)
KTR02589.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
KTR02590.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
KTR02418.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (467 aa)
KTR02332.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa)
Your Current Organism:
Curtobacterium luteum
NCBI taxonomy Id: 33881
Other names: ATCC 15830, Brevibacterium luteum, C. luteum, CCUG 23848, CIP 102694, Curtibacterium luteum, DSM 20542, IFO 12676, LMG 8787, LMG:8787, NBRC 12676
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