STRINGSTRING
KZE22151.1 KZE22151.1 AVW13_16900 AVW13_16900 KZE11172.1 KZE11172.1 murD murD KZE12147.1 KZE12147.1 KZE12293.1 KZE12293.1 AVW13_15875 AVW13_15875 serS serS KZE15980.1 KZE15980.1 hisA hisA KZE15983.1 KZE15983.1 KZE16190.1 KZE16190.1 trpD trpD pyrD pyrD KZE16154.1 KZE16154.1 thiC thiC KZE17677.1 KZE17677.1 AVW13_13675 AVW13_13675 selA selA KZE17621.1 KZE17621.1 KZE17957.1 KZE17957.1 purM purM purF purF purC purC purS purS purQ purQ pdxA pdxA KZE18463.1 KZE18463.1 prs prs glmU glmU purH purH purN purN KZE18384.1 KZE18384.1 KZE19095.1 KZE19095.1 sigA sigA hemH hemH dut dut dxs dxs hemE hemE KZE19049.1 KZE19049.1 KZE19048.1 KZE19048.1 KZE19045.1 KZE19045.1 dnaG dnaG nadE nadE KZE19141.1 KZE19141.1 KZE19118.1 KZE19118.1 tmk tmk acsA acsA KZE19611.1 KZE19611.1 KZE20173.1 KZE20173.1 KZE20162.1 KZE20162.1 upp upp KZE20126.1 KZE20126.1 KZE20204.1 KZE20204.1 purU purU folD folD nadD nadD ndk ndk KZE20868.1 KZE20868.1 KZE20902.1 KZE20902.1 murA murA KZE20831.1 KZE20831.1 atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB rho rho KZE20807.1 KZE20807.1 KZE20803.1 KZE20803.1 aroA aroA pyrE pyrE AVW13_09305 AVW13_09305 pheA pheA prpE prpE aroD aroD dcd dcd KZE21540.1 KZE21540.1 KZE21536.1 KZE21536.1 kynU kynU KZE21487.1 KZE21487.1 guaB guaB thiM thiM thiE-2 thiE-2 KZE22266.1 KZE22266.1 KZE22265.1 KZE22265.1 KZE22262.1 KZE22262.1 KZE22261.1 KZE22261.1 nadA nadA KZE22254.1 KZE22254.1 guaA guaA coaA coaA KZE22531.1 KZE22531.1 folE folE KZE22528.1 KZE22528.1 KZE22579.1 KZE22579.1 KZE22517.1 KZE22517.1 hemA hemA KZE22483.1 KZE22483.1 KZE22482.1 KZE22482.1 hemL hemL KZE22473.1 KZE22473.1 KZE22444.1 KZE22444.1 KZE22572.1 KZE22572.1 KZE22424.1 KZE22424.1 KZE22420.1 KZE22420.1 nusG nusG rpoB rpoB rpoC rpoC adk adk KZE22599.1 KZE22599.1 rpoA rpoA KZE23004.1 KZE23004.1 KZE22992.1 KZE22992.1 apt apt KZE22895.1 KZE22895.1 KZE22878.1 KZE22878.1 thiL thiL coaD coaD pyrH pyrH nusA nusA KZE22794.1 KZE22794.1 KZE23106.1 KZE23106.1 purL purL purA purA KZE23452.1 KZE23452.1 KZE23448.1 KZE23448.1 pdxH pdxH serC serC cmk cmk KZE24422.1 KZE24422.1 pyrG pyrG KZE24410.1 KZE24410.1 nadK nadK KZE08809.1 KZE08809.1 AVW13_03675 AVW13_03675 KZE10017.1 KZE10017.1 tdk-2 tdk-2 thiG thiG KZE09976.1 KZE09976.1 KZE09975.1 KZE09975.1 thiE thiE KZE09942.1 KZE09942.1 pdxT pdxT pdxS pdxS tdk tdk KZE10006.1 KZE10006.1 KZE11090.1 KZE11090.1 KZE11831.1 KZE11831.1 dinB dinB KZE13301.1 KZE13301.1 dnaE2 dnaE2 KZE18252.1 KZE18252.1 KZE18226.1 KZE18226.1 ctaB ctaB coaE coaE polA polA trpA trpA trpB trpB trpC trpC trpE trpE KZE18187.1 KZE18187.1 KZE18176.1 KZE18176.1 rpoZ rpoZ gmk gmk KZE18172.1 KZE18172.1 carB carB carA carA KZE18169.1 KZE18169.1 pyrC pyrC pyrB pyrB nusB nusB aroB aroB aroK aroK aroC aroC KZE18159.1 KZE18159.1 KZE18148.1 KZE18148.1 KZE18124.1 KZE18124.1 KZE22162.1 KZE22162.1 purE purE KZE22111.1 KZE22111.1 KZE24480.1 KZE24480.1 KZE24494.1 KZE24494.1 KZE24628.1 KZE24628.1 KZE24635.1 KZE24635.1 purU-2 purU-2 KZE24559.1 KZE24559.1 KZE24575.1 KZE24575.1 KZE24591.1 KZE24591.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
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gene neighborhood
gene fusions
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co-expression
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KZE22151.1Phosphoheptose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
AVW13_16900Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
KZE11172.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (519 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (497 aa)
KZE12147.1DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology. (1193 aa)
KZE12293.1DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
AVW13_15875Transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
serSserine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
KZE15980.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (168 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
KZE15983.1Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (729 aa)
KZE16190.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (373 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (367 aa)
KZE16154.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (109 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (596 aa)
KZE17677.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
AVW13_13675LysR family transcriptional regulator; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (445 aa)
selAL-selenocysteinyl-tRNA(Sec) synthase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (486 aa)
KZE17621.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
KZE17957.1Transcriptional regulator, TENA/THI-4 family protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (227 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (493 aa)
purCPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (749 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (84 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (243 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PdxA family. (348 aa)
KZE18463.1DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (484 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (515 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa)
KZE18384.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (439 aa)
KZE19095.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1169 aa)
sigARNA polymerase subunit sigma; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (488 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (359 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (153 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (646 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (351 aa)
KZE19049.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (474 aa)
KZE19048.1Chlorite dismutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
KZE19045.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (671 aa)
nadENAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (278 aa)
KZE19141.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (426 aa)
KZE19118.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (925 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (644 aa)
KZE19611.1CarD family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
KZE20173.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
KZE20162.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa)
KZE20126.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (552 aa)
KZE20204.1Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (216 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa)
nadDNicotinate-nicotinamide nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (201 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
KZE20868.1Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (456 aa)
KZE20902.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (437 aa)
KZE20831.1ATP synthase F0F1 subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (483 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (310 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (544 aa)
atpHATP synthase F0F1 subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (268 aa)
atpFATP synthase F0F1 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (183 aa)
atpEATP F0F1 synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa)
atpBATP synthase F0F1 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (248 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (653 aa)
KZE20807.1Guanosine monophosphate reductase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
KZE20803.1RNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (204 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (435 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (189 aa)
AVW13_09305Alkaline-shock protein; Incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
prpEpropionate--CoA ligase; Catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (640 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (274 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (192 aa)
KZE21540.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
KZE21536.1Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (424 aa)
KZE21487.1RNA polymerase subunit sigma; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (204 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (508 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (286 aa)
thiE-2Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (235 aa)
KZE22266.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Catalyzes the formation hydroxymethylpyrimidine phosphate from hydroxymethylpyrimidine and the formation of of 4-amino-2-methyl-5-diphosphomethylpyrimidine from hydroxymethylpyrimidine phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
KZE22265.1Thiamine metabolism protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
KZE22262.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (327 aa)
KZE22261.1L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (545 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (427 aa)
KZE22254.1Guanosine monophosphate reductase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
coaAPantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
KZE22531.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa)
folEGTP cyclohydrolase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
KZE22528.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (277 aa)
KZE22579.1Hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (296 aa)
KZE22517.1Bleomycin resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA); Belongs to the HMBS family. (827 aa)
KZE22483.1Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
KZE22482.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (327 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
KZE22473.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
KZE22444.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (534 aa)
KZE22572.1Cobalamin biosynthesis protein CbiX; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
KZE22424.1uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (263 aa)
KZE22420.1Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
nusGTranscription termination factor NusG; Participates in transcription elongation, termination and antitermination. (265 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1159 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1290 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (188 aa)
KZE22599.1PaaX family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa)
KZE23004.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
KZE22992.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
KZE22895.1Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (261 aa)
KZE22878.1UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (438 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (337 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (162 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (250 aa)
nusATranscription elongation factor NusA; Participates in both transcription termination and antitermination. (320 aa)
KZE22794.1Bifunctional riboflavin kinase/FMN adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (312 aa)
KZE23106.1RNA polymerase subunit sigma-70; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (783 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
KZE23452.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. (145 aa)
KZE23448.1Ketosteroid isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (389 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
KZE24422.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (559 aa)
KZE24410.1Thiamin pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
nadKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (308 aa)
KZE08809.1Pterin-4-alpha-carbinolamine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AVW13_03675GrpB domain protein; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
KZE10017.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
tdk-2Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (268 aa)
KZE09976.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
KZE09975.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (225 aa)
KZE09942.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (193 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
KZE10006.1Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
KZE11090.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
KZE11831.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (434 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (412 aa)
KZE13301.1Fatty acid-binding protein; May play a role in the intracellular transport of hydrophobic ligands. (199 aa)
dnaE2DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1039 aa)
KZE18252.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
KZE18226.1Cytochrome oxidase assembly protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (328 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (302 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (896 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (262 aa)
trpEAnthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (511 aa)
KZE18187.1acetyl-CoA carboxyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
KZE18176.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (417 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (115 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (187 aa)
KZE18172.1Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (287 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1091 aa)
carACarbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (379 aa)
KZE18169.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (325 aa)
nusBAntitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (135 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (370 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (207 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (397 aa)
KZE18159.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
KZE18148.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (765 aa)
KZE18124.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (409 aa)
KZE22162.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (179 aa)
KZE22111.1RNA polymerase subunit sigma-24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (425 aa)
KZE24480.14-hydroxythreonine-4-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PdxA family. (343 aa)
KZE24494.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
KZE24628.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
KZE24635.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (281 aa)
KZE24559.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
KZE24575.1Glutamine amidotransferase class-I; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
KZE24591.13'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (607 aa)
Your Current Organism:
Brevibacterium casei
NCBI taxonomy Id: 33889
Other names: ATCC 35513, B. casei, BCRC 12214, CCM 4100, CCRC 12214, CCRC:12214, CCUG 29001, CDC coryneform group B-1, CDC coryneform group B-3, CIP 102111, DSM 20657, IFO 14812, IMET 10997, JCM 2594, KCTC 3082, KCTC 3085, NBRC 14812, NCDO 2048, NCIMB 702048, VKM Ac-2114
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