STRINGSTRING
rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ rpsG rpsG rplL rplL rplJ rplJ rplK rplK rpmG rpmG Pcar_0670 Pcar_0670 srtN srtN recO recO Pcar_0558 Pcar_0558 ackA-2 ackA-2 Pcar_0522 Pcar_0522 eutBC-1 eutBC-1 eutBC-2 eutBC-2 shc-2 shc-2 Pcar_0435 Pcar_0435 recR recR Pcar_0375 Pcar_0375 Pcar_0369 Pcar_0369 Pcar_0358 Pcar_0358 hspA-2 hspA-2 shc-1 shc-1 Pcar_0292 Pcar_0292 Pcar_0125 Pcar_0125 Pcar_0065 Pcar_0065 nth-2 nth-2 recF recF dnaA dnaA rpsE rpsE rpmD rpmD rplO rplO rpmJ rpmJ rpsK rpsK rpsD rpsD rplQ rplQ Pcar_0763 Pcar_0763 priA priA Pcar_0791 Pcar_0791 Pcar_0796 Pcar_0796 Pcar_0803 Pcar_0803 Pcar_0844 Pcar_0844 Pcar_0849 Pcar_0849 Pcar_0929 Pcar_0929 Pcar_0934 Pcar_0934 Pcar_0985 Pcar_0985 rarA-2 rarA-2 Pcar_1140 Pcar_1140 Pcar_1181 Pcar_1181 Pcar_1268 Pcar_1268 Pcar_1269 Pcar_1269 neuB neuB rpmB rpmB Pcar_1308 Pcar_1308 Pcar_1314 Pcar_1314 Pcar_1315 Pcar_1315 Pcar_1344 Pcar_1344 Pcar_1362 Pcar_1362 rpsT rpsT rpmI rpmI rplT rplT ihfA-1 ihfA-1 rpmF rpmF Pcar_1443 Pcar_1443 ihfB-1 ihfB-1 Pcar_1476 Pcar_1476 Pcar_1558 Pcar_1558 rpsO rpsO Pcar_1600 Pcar_1600 hup hup Pcar_1809 Pcar_1809 Pcar_1822 Pcar_1822 ihfB-2 ihfB-2 rpsA rpsA rpsI rpsI rplM rplM rpsB rpsB raiA raiA dnaB dnaB rplI rplI rpsR rpsR rpsF rpsF rplY rplY Pcar_2020 Pcar_2020 Pcar_2032 Pcar_2032 Pcar_2051 Pcar_2051 Pcar_2071 Pcar_2071 draG draG Pcar_2111 Pcar_2111 Pcar_2131 Pcar_2131 rpsP rpsP rpsU rpsU Pcar_2274 Pcar_2274 Pcar_2277 Pcar_2277 Pcar_2294 Pcar_2294 Pcar_2317 Pcar_2317 recN recN rarA-1 rarA-1 smc smc recQ recQ ackA ackA Pcar_2484 Pcar_2484 ackA-1 ackA-1 rpmA rpmA rplU rplU Pcar_2665 Pcar_2665 Pcar_2672 Pcar_2672 dnaG dnaG rpmE rpmE Pcar_2744 Pcar_2744 Pcar_2931 Pcar_2931 Pcar_2932 Pcar_2932 Pcar_2998 Pcar_2998 Pcar_3012 Pcar_3012 dtd dtd Pcar_3089 Pcar_3089 Pcar_3102 Pcar_3102 Pcar_3138 Pcar_3138 rpmH rpmH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (122 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (184 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (109 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa)
rpmCRibosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (62 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (210 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (110 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa)
rplDRibosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (206 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (210 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (172 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa)
rpmGRibosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
Pcar_06704helix_suffix domain protein. (207 aa)
srtNNAD-dependent protein deacetylase, Sir2 family. (278 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (258 aa)
Pcar_0558Lipoprotein cytochrome c, 1 heme-binding site. (150 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (420 aa)
Pcar_0522ATPase, AAA family. (332 aa)
eutBC-1Ethanolamine ammonia-lyase. (753 aa)
eutBC-2Ethanolamine ammonia-lyase. (755 aa)
shc-2Squalene cyclase. (737 aa)
Pcar_0435Hypothetical protein. (162 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
Pcar_0375DNA-binding protein, YbaB/EbfC family; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa)
Pcar_0369ATP-independent chaperone, alpha-crystallin/Hsp20 family; Belongs to the small heat shock protein (HSP20) family. (153 aa)
Pcar_0358ATP-independent chaperone, alpha-crystallin/Hsp20 family; Belongs to the small heat shock protein (HSP20) family. (134 aa)
hspA-2ATP-independent chaperone, alpha-crystallin/Hsp20 family; Belongs to the small heat shock protein (HSP20) family. (148 aa)
shc-1Squalene cyclase. (695 aa)
Pcar_0292Protein of unknown function, DUF2726 and zinc finger-containing. (255 aa)
Pcar_0125Integrase core domain protein. (625 aa)
Pcar_0065Protein of unknown function DUF2466; Belongs to the UPF0758 family. (227 aa)
nth-2Endonuclease III-related DNA glycosidase, HhH-GPD superfamily; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (363 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (450 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (163 aa)
rpmDRibosomal protein L30. (59 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
rpmJRibosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (209 aa)
rplQRibosomal protein L17. (155 aa)
Pcar_0763Metallophosphoesterase. (285 aa)
priAPrimosomal protein N', ATP-dependent helicase; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa)
Pcar_0791ATP/GTP-binding transposition helper; Belongs to the DnaA family. (255 aa)
Pcar_0796Hypothetical protein. (535 aa)
Pcar_0803Protein of unknown function DUF2466; Belongs to the UPF0758 family. (166 aa)
Pcar_0844Hypothetical protein. (744 aa)
Pcar_0849Protein of unknown function DUF3450. (272 aa)
Pcar_0929ADP-ribosyl-glycohydrolase superfamily protein. (261 aa)
Pcar_0934Hypothetical protein. (308 aa)
Pcar_0985Protein of unknown function DUF159; Belongs to the SOS response-associated peptidase family. (227 aa)
rarA-2Stalled replication fork rescue ATPase, long form. (726 aa)
Pcar_1140N-acetylneuraminate synthase family protein. (287 aa)
Pcar_1181Adenylate/guanylate cyclase; Domains: CHD, TPR. (1134 aa)
Pcar_1268Kinase, putative. (466 aa)
Pcar_1269Kinase, putative. (252 aa)
neuBN-acetylneuraminate synthase. (288 aa)
rpmBRibosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (63 aa)
Pcar_1308TPR domain protein. (272 aa)
Pcar_1314Ferritin-like domain protein. (166 aa)
Pcar_1315Ferritin-like domain protein. (171 aa)
Pcar_1344ADP-ribosyl-glycohydrolase superfamily protein. (375 aa)
Pcar_1362GFA family protein. (137 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
rpmIRibosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
ihfA-1Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (93 aa)
rpmFRibosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (58 aa)
Pcar_1443Deoxycytidylate deaminase. (158 aa)
ihfB-1Integration host factor, beta subunit; Belongs to the bacterial histone-like protein family. (92 aa)
Pcar_1476Hypothetical protein. (574 aa)
Pcar_1558Phosphoesterase, putative. (318 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (88 aa)
Pcar_1600ATPase, AAA family. (332 aa)
hupHistone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
Pcar_1809Hypothetical protein. (1121 aa)
Pcar_1822Hypothetical protein. (574 aa)
ihfB-2Integration host factor, beta subunit; Belongs to the bacterial histone-like protein family. (94 aa)
rpsARibosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (573 aa)
rpsIRibosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsBRibosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (267 aa)
raiARibosomal subunit interface-associated sigma-54 modulation protein RaiA; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (182 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (456 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (148 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (91 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (115 aa)
rplYRibosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (208 aa)
Pcar_2020TPR domain lipoprotein. (255 aa)
Pcar_2032DHH domain phosphoesterase, putative. (349 aa)
Pcar_2051Helicase, putative. (637 aa)
Pcar_2071Protein of unknown function DUF477. (338 aa)
draGADP-ribosyl-(nitrogenase)-activating glycohydrolase. (307 aa)
Pcar_2111Ferritin-like domain protein. (169 aa)
Pcar_2131TPR domain protein. (265 aa)
rpsPRibosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (86 aa)
rpsURibosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (64 aa)
Pcar_2274Rhodanese homology domain and ferritin-like domain protein. (280 aa)
Pcar_2277Protein of unknown function DUF477. (235 aa)
Pcar_2294Hypothetical protein. (259 aa)
Pcar_2317Transcriptional regulator, Ros/MucR family. (147 aa)
recNDNA repair ATPase RecN; May be involved in recombinational repair of damaged DNA. (560 aa)
rarA-1Stalled replication fork rescue ATPase. (432 aa)
smcChromosome segregation ATPase SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1173 aa)
recQATP-dependent DNA helicase RecQ. (596 aa)
ackAPropionate kinase, putative; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
Pcar_2484Metallophosphoesterase. (375 aa)
ackA-1Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa)
rpmARibosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (84 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
Pcar_2665FAD-dependent pyridine nucleotide-disulfide oxidoreductase family protein. (495 aa)
Pcar_2672RNA-binding S1 domain protein. (399 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (604 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (69 aa)
Pcar_2744Ferritin-like domain protein. (167 aa)
Pcar_2931Tn7 transposase protein TnsB. (672 aa)
Pcar_2932Tn7 transposase protein TnsA. (271 aa)
Pcar_2998Hypothetical protein. (102 aa)
Pcar_3012Flavin and coenzyme A sequestration protein dodecin. (71 aa)
dtdD-aminoacyl-tRNA deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa)
Pcar_3089Hypothetical protein. (204 aa)
Pcar_3102TPR domain protein. (313 aa)
Pcar_3138ParB-like nuclease domain protein, putative transcriptional regulator; Belongs to the ParB family. (284 aa)
rpmHRibosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (50 aa)
Your Current Organism:
Pelobacter carbinolicus
NCBI taxonomy Id: 338963
Other names: P. carbinolicus DSM 2380, Pelobacter carbinolicus DSM 2380, Pelobacter carbinolicus Gra Bd 1, Pelobacter carbinolicus str. DSM 2380, Pelobacter carbinolicus strain DSM 2380
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