Your Input: | |
| | cysS | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: gme:Gmet_0057 cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (493 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (465 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (388 aa) |
| | Ppro_0046 | KEGG: gme:Gmet_0603 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (365 aa) |
| | Ppro_0047 | KEGG: gme:Gmet_0604 aspartate-semialdehyde dehydrogenase, USG-1 related; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | Ppro_0050 | PFAM: asparagine synthase; KEGG: mlo:mll5256 similar to asparagine synthetase. (636 aa) |
| | Ppro_0088 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | Ppro_0225 | KEGG: rba:RB5963 hypothetical protein. (159 aa) |
| | Ppro_0283 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. (615 aa) |
| | Ppro_0296 | KEGG: gme:Gmet_0495 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (162 aa) |
| | Ppro_0302 | Methylthioadenosine nucleosidase; PFAM: purine and other phosphorylases, family 1; KEGG: gsu:GSU1897 MTA/SAH nucleosidase, putative. (241 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (234 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (287 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (346 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | hisZ | histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (445 aa) |
| | Ppro_0653 | KEGG: gme:Gmet_1988 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (275 aa) |
| | birA | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (324 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (254 aa) |
| | Ppro_0660 | KEGG: gme:Gmet_1980 hypothetical protein. (213 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: gme:Gmet_2494 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (350 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa) |
| | Ppro_0734 | D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: bca:BCE3284 D-3-phosphoglycerate dehydrogenase, putative. (390 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (364 aa) |
| | Ppro_0748 | TIGRFAM: serine O-acetyltransferase; KEGG: gme:Gmet_0870 serine O-acetyltransferase. (230 aa) |
| | Ppro_0829 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (370 aa) |
| | Ppro_0957 | PFAM: Silent information regulator protein Sir2; KEGG: pca:Pcar_0631 NAD-dependent protein deacetylase SIR2 family-like. (253 aa) |
| | Ppro_1070 | PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: vpa:VP0926 hypothetical protein. (202 aa) |
| | Ppro_1145 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: bms:BR0849 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (996 aa) |
| | Ppro_1152 | KEGG: gme:Gmet_1940 phosphoribosylformylglycinamidine synthase I, putative. (275 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (474 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa) |
| | Ppro_1160 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: gme:Gmet_2475 folylpolyglutamate synthetase. (425 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gme:Gmet_2492 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (209 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa) |
| | Ppro_1294 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: gme:Gmet_1629 homoserine dehydrogenase. (438 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | Ppro_1345 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; amino acid-binding ACT domain protein; KEGG: gme:Gmet_0862 chorismate mutase, gamma, beta and epsilon. (359 aa) |
| | Ppro_1346 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: gme:Gmet_0863 prephenate dehydrogenase:NAD-dependent glycerol-3-phosphate dehydrogenase-like. (287 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (394 aa) |
| | Ppro_1413 | Methionine synthase (B12-dependent); PFAM: dihydropteroate synthase, DHPS; homocysteine S-methyltransferase; Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: gme:Gmet_0549 homocysteine S-methyltransferase. (806 aa) |
| | Ppro_1493 | PFAM: fumarate lyase; KEGG: pca:Pcar_1630 aspartate ammonia-lyase, putative. (471 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: reu:Reut_A2574 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (375 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (288 aa) |
| | Ppro_1581 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: gsu:GSU2382 anthranilate synthase component II. (191 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (491 aa) |
| | Ppro_1585 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: gme:Gmet_0346 3-deoxy-7-phosphoheptulonate synthase. (339 aa) |
| | Ppro_1595 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: gsu:GSU1689 riboflavin synthase, alpha subunit. (213 aa) |
| | Ppro_1596 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | nrdR | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (150 aa) |
| | Ppro_1598 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: gsu:GSU1686 cytidine/deoxycytidylate deaminase family protein. (155 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (401 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (240 aa) |
| | Ppro_1699 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: gsu:GSU1198 D-3-phosphoglycerate dehydrogenase. (539 aa) |
| | Ppro_1723 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. (223 aa) |
| | Ppro_1734 | KEGG: gme:Gmet_1956 hypothetical protein. (69 aa) |
| | Ppro_1735 | PFAM: Chorismate mutase; KEGG: gme:Gmet_1955 chorismate mutase. (94 aa) |
| | Ppro_1736 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (531 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: gsu:GSU1758 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (350 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (206 aa) |
| | Ppro_1787 | KEGG: gme:Gmet_2390 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. (428 aa) |
| | Ppro_1830 | Cysteine synthase / cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: gme:Gmet_0698 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme. (383 aa) |
| | Ppro_1831 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: gme:Gmet_0699 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme. (381 aa) |
| | Ppro_1832 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: sat:SYN_01253 cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (317 aa) |
| | Ppro_1995 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: gme:Gmet_0219 Orn/DAP/Arg decarboxylase 2. (439 aa) |
| | Ppro_1996 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: gme:Gmet_0106 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (312 aa) |
| | Ppro_1997 | PFAM: nitroreductase; KEGG: pca:Pcar_1624 NADPH-oxidoreductase-like. (182 aa) |
| | Ppro_1998 | PFAM: aminotransferase, class I and II; KEGG: pca:Pcar_3031 putative aminotransferase. (383 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (393 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (689 aa) |
| | Ppro_2166 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: pca:Pcar_0629 D-3-phosphoglycerate dehydrogenase. (357 aa) |
| | Ppro_2167 | 2,3-dimethylmalate lyase; TIGRFAM: phosphoenolpyruvate phosphomutase; KEGG: pca:Pcar_0628 phosphoenolpyruvate phosphomutase. (297 aa) |
| | Ppro_2168 | KEGG: pca:Pcar_0630 ATP-grasp enzyme-like. (411 aa) |
| | Ppro_2253 | KEGG: sat:SYN_02778 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS. (400 aa) |
| | Ppro_2262 | KEGG: gme:Gmet_1880 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (404 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (277 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | Ppro_2361 | PFAM: shikimate kinase; KEGG: pca:Pcar_2174 shikimate kinase II. (175 aa) |
| | Ppro_2395 | KEGG: gsu:GSU1695 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (461 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (202 aa) |
| | Ppro_2427 | PFAM: NUDIX hydrolase; KEGG: gme:Gmet_0714 NUDIX hydrolase. (301 aa) |
| | Ppro_2466 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase; KEGG: dar:Daro_2408 asparagine synthase, glutamine-hydrolyzing. (625 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: gme:Gmet_1774 carbamoyl-phosphate synthase, large subunit, glutamine-dependent; Belongs to the CarB family. (1078 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: gsu:GSU1273 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (373 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: gme:Gmet_1769 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | pyrR | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (185 aa) |
| | Ppro_2543 | L-fuculose 1-phosphate aldolase; PFAM: class II aldolase/adducin family protein; KEGG: pca:Pcar_3030 L-fuculose phosphate aldolase. (237 aa) |
| | Ppro_2550 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa) |
| | purD | Phosphoribosylamine--glycine ligase; KEGG: gme:Gmet_2904 phosphoribosylglycinamide synthetase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (423 aa) |
| | purH | IMP cyclohydrolase; KEGG: gsu:GSU0609 phosphoribosylaminoimidazolecarboxamide formyltransferase. (521 aa) |
| | Ppro_2599 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: gme:Gmet_0024 3-deoxy-7-phosphoheptulonate synthase. (339 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (304 aa) |
| | pyrK | Dihydroorotate oxidase B, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (272 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (245 aa) |
| | Ppro_2669 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa) |
| | surE | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (247 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | Ppro_2800 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: ttj:TTHA1328 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. (601 aa) |
| | Ppro_2808 | TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: gsu:GSU0523 para-aminobenzoate synthase, component I. (592 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | Ppro_2829 | Sulfide dehydrogenase (flavoprotein) subunit SudB; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU3058 dihydroorotate dehydrogenase, electron transfer subunit, putative. (279 aa) |
| | Ppro_2839 | PFAM: S-adenosylmethionine synthetase (MAT); KEGG: sat:SYN_00253 S-adenosylmethionine synthetase. (400 aa) |
| | Ppro_2871 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase; KEGG: sme:SMb20652 putative asparagine synthetase protein. (678 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (125 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (291 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | Ppro_3004 | PFAM: phosphoribosyltransferase; KEGG: gsu:GSU1017 hypoxanthine phosphoribosyltransferase, putative. (183 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: gme:Gmet_0385 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | hisG-2 | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa) |
| | Ppro_3051 | PFAM: Colicin V production protein; KEGG: gme:Gmet_0393 colicin V production protein. (163 aa) |
| | hisE | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gme:Gmet_0390 phosphoribosyl-ATP pyrophosphohydrolase. (108 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa) |
| | dapL | LL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (410 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (267 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | purC | KEGG: gme:Gmet_0916 SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (296 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: gsu:GSU0156 argininosuccinate lyase. (458 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: gsu:GSU0153 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (305 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: gme:Gmet_0204 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (398 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa) |
| | Ppro_3202 | KEGG: xcv:XCV3330 putative MFS transporter, AGZA family, xanthine/uracil permease. (518 aa) |
| | Ppro_3262 | PFAM: dihydrodipicolinate reductase; KEGG: tte:TTE0831 dihydrodipicolinate reductase; Belongs to the DapB family. (251 aa) |
| | Ppro_3359 | TIGRFAM: cysteine synthases; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: gme:Gmet_0264 cysteine synthase K/M. (305 aa) |
| | ppnP | Protein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (104 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (371 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (131 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (269 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
