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Ppro_0013 Ppro_0013 Ppro_0094 Ppro_0094 Ppro_0157 Ppro_0157 Ppro_0314 Ppro_0314 Ppro_0315 Ppro_0315 clpX clpX clpP clpP htpG htpG dnaJ dnaJ dnaK dnaK grpE grpE hrcA hrcA clpB clpB Ppro_2145 Ppro_2145 ftsH ftsH Ppro_2600 Ppro_2600 Ppro_2603 Ppro_2603 lon lon Ppro_2605 Ppro_2605 groL groL groS groS ftsH-2 ftsH-2 Ppro_2917 Ppro_2917 lon-2 lon-2 htpX htpX hslO hslO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ppro_0013PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: gme:Gmet_3550 heat shock protein DnaJ-like. (302 aa)
Ppro_0094PFAM: Enoyl-CoA hydratase/isomerase; KEGG: bur:Bcep18194_C7186 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
Ppro_0157PFAM: Heat shock protein 70; KEGG: cdi:DIP2120 chaperone protein DnaK. (533 aa)
Ppro_0314PFAM: heat shock protein Hsp20; KEGG: gsu:GSU2409 heat shock protein, HSP20 family; Belongs to the small heat shock protein (HSP20) family. (132 aa)
Ppro_0315PFAM: heat shock protein Hsp20; KEGG: gsu:GSU2410 heat shock protein, HSP20 family; Belongs to the small heat shock protein (HSP20) family. (149 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (418 aa)
clpPATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (199 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (645 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (384 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (636 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (190 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (343 aa)
clpBATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (873 aa)
Ppro_2145KEGG: ade:Adeh_2261 molecular chaperone-like. (423 aa)
ftsHMembrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (621 aa)
Ppro_2600Transcriptional regulator, Crp/Fnr family; PFAM: cyclic nucleotide-binding; regulatory protein, Crp; KEGG: gme:Gmet_0092 transcriptional regulator, Crp/Fnr family. (229 aa)
Ppro_2603TIGRFAM: uncharacterized domain 1; PFAM: thioesterase superfamily protein; KEGG: eli:ELI_09835 phenylacetic acid degradation-related protein. (149 aa)
lonATP-dependent proteinase, Serine peptidase, MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (823 aa)
Ppro_2605PFAM: heat shock protein Hsp20; KEGG: gsu:GSU3192 heat shock protein, HSP20 family; Belongs to the small heat shock protein (HSP20) family. (144 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (554 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
ftsH-2ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (623 aa)
Ppro_2917KEGG: gsu:GSU2756 hypothetical protein. (244 aa)
lon-2ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (771 aa)
htpXHeat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; KEGG: gsu:GSU1567 peptidase, M48 family; Belongs to the peptidase M48B family. (282 aa)
hslOHsp33 protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. (304 aa)
Your Current Organism:
Pelobacter propionicus
NCBI taxonomy Id: 338966
Other names: P. propionicus DSM 2379, Pelobacter propionicus DSM 2379, Pelobacter propionicus str. DSM 2379, Pelobacter propionicus strain DSM 2379
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