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Ppro_0002 Ppro_0002 recF recF gyrB gyrB gyrA gyrA Ppro_0006 Ppro_0006 Ppro_0008 Ppro_0008 Ppro_0009 Ppro_0009 Ppro_0025 Ppro_0025 Ppro_0109 Ppro_0109 recD2 recD2 Ppro_0200 Ppro_0200 Ppro_0233 Ppro_0233 recR recR Ppro_0300 Ppro_0300 dnaX dnaX radA radA Ppro_0449 Ppro_0449 nfo nfo mfd mfd Ppro_0509 Ppro_0509 topA topA Ppro_0534 Ppro_0534 Ppro_0663 Ppro_0663 Ppro_0949 Ppro_0949 Ppro_1000 Ppro_1000 Ppro_1003 Ppro_1003 mutS mutS Ppro_1151 Ppro_1151 Ppro_1316 Ppro_1316 Ppro_1578 Ppro_1578 Ppro_1637 Ppro_1637 Ppro_1664 Ppro_1664 Ppro_1733 Ppro_1733 Ppro_1847 Ppro_1847 recD2-2 recD2-2 Ppro_1873 Ppro_1873 Ppro_2068 Ppro_2068 recC recC recB recB recD recD Ppro_2320 Ppro_2320 ruvB ruvB Ppro_2346 Ppro_2346 coaE coaE Ppro_2531 Ppro_2531 Ppro_2537 Ppro_2537 sbcD sbcD Ppro_2570 Ppro_2570 priA priA ruvA ruvA ruvC ruvC Ppro_2673 Ppro_2673 Ppro_2733 Ppro_2733 polA polA recO recO mutL mutL dnaG dnaG Ppro_3126 Ppro_3126 recX recX recA recA uvrC uvrC Ppro_3458 Ppro_3458 uvrB uvrB uvrA uvrA Ppro_3587 Ppro_3587 mutM mutM
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Ppro_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (373 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (370 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (802 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (843 aa)
Ppro_0006KEGG: gme:Gmet_0006 hypothetical protein. (536 aa)
Ppro_0008KEGG: msu:MS2166 hypothetical protein. (341 aa)
Ppro_0009TIGRFAM: death-on-curing family protein; PFAM: Death-on-curing protein; KEGG: wsu:WS1132 hypothetical protein. (150 aa)
Ppro_0025KEGG: gme:Gmet_3009 hypothetical protein. (296 aa)
Ppro_0109PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase; KEGG: chy:CHY_1116 ISChy4, transposition helper protein. (258 aa)
recD2Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (728 aa)
Ppro_0200TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: gsu:GSU2151 single-strand binding protein. (139 aa)
Ppro_0233Hypothetical protein. (87 aa)
recRDNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (197 aa)
Ppro_0300Conserved hypothetical protein 103; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa)
dnaXDNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (569 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (448 aa)
Ppro_0449Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (143 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (283 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1177 aa)
Ppro_0509SMART: helicase c2; DEAD-like helicases-like; KEGG: gme:Gmet_3167 helicase C2. (843 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (776 aa)
Ppro_0534Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (458 aa)
Ppro_0663PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. (218 aa)
Ppro_0949Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (482 aa)
Ppro_1000KEGG: gsu:GSU1359 helicase, putative. (67 aa)
Ppro_1003PFAM: NERD domain protein; KEGG: dra:DR1757 hypothetical protein. (344 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (870 aa)
Ppro_1151KEGG: gsu:GSU0898 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like. (714 aa)
Ppro_1316PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like; KEGG: dde:Dde_2493 DEAD/DEAH box helicase-like. (796 aa)
Ppro_1578DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. (556 aa)
Ppro_1637TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: gsu:GSU1539 exodeoxyribonuclease III. (270 aa)
Ppro_1664TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: gsu:GSU2230 DNA polymerase III, delta prime subunit. (327 aa)
Ppro_1733TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; KEGG: gme:Gmet_2298 DNA polymerase III, delta subunit. (338 aa)
Ppro_1847PFAM: DEAD_2 domain protein; SMART: DEXDc2; helicase c2; KEGG: bba:Bd0255 similar to ATP dependent helicase. (807 aa)
recD2-2Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (728 aa)
Ppro_1873PFAM: UvrD/REP helicase; KEGG: bfs:BF1103 putative ATP-dependent DNA helicase. (591 aa)
Ppro_2068KEGG: gme:Gmet_1215 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP C-terminal domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1184 aa)
recCDNA helicase/exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recomb [...] (1061 aa)
recBDNA helicase/exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombi [...] (1203 aa)
recDDNA helicase/exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recomb [...] (604 aa)
Ppro_2320PFAM: Chromosomal replication initiator, DnaA; SMART: AAA ATPase; KEGG: gme:Gmet_0747 chromosomal replication initiator protein, DnaA; Belongs to the DnaA family. (236 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (338 aa)
Ppro_2346DNA-directed DNA polymerase; KEGG: gsu:GSU1383 exonuclease; PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease. (170 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
Ppro_2531KEGG: pca:Pcar_2914 superfamily I DNA and RNA helicases-like. (636 aa)
Ppro_2537PFAM: UvrD/REP helicase; KEGG: gme:Gmet_2724 UvrD/REP helicase. (672 aa)
sbcDExodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (410 aa)
Ppro_2570PFAM: SMC domain protein; KEGG: sat:SYN_00200 exonuclease. (1230 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (744 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (198 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (176 aa)
Ppro_2673PFAM: protein of unknown function DUF28; KEGG: gsu:GSU1074 hypothetical protein. (247 aa)
Ppro_2733PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicases-like; KEGG: gme:Gmet_0994 SNF2-related:helicase-like:zinc finger, SWIM-type. (1164 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (893 aa)
recODNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (246 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (608 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (584 aa)
Ppro_3126PFAM: DnaB domain protein helicase, C-terminal domain protein; KEGG: ilo:IL1933 replicative DNA helicase. (419 aa)
recXRegulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (163 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (340 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (617 aa)
Ppro_3458ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: gme:Gmet_0089 UvrD/REP helicase. (762 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (701 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (954 aa)
Ppro_3587KEGG: gme:Gmet_3223 UvrD/REP helicase. (446 aa)
mutMDNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (267 aa)
Your Current Organism:
Pelobacter propionicus
NCBI taxonomy Id: 338966
Other names: P. propionicus DSM 2379, Pelobacter propionicus DSM 2379, Pelobacter propionicus str. DSM 2379, Pelobacter propionicus strain DSM 2379
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